Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. Academic Article uri icon

Overview

abstract

  • We determined the effects of platelet-activating factor (PAF), a potent vasoactive autacoid phospholipid, on the capillary pressure and liver weight (Wt) in isolated canine livers perfused with blood bivascularly via the portal vein and hepatic artery. PAF (0.01-33 microg) administered intraportally produced dose-dependent increases in the hepatic capillary pressure, as assessed by triple vascular occlusion pressure (Pto), and Wt. An intraportal injection of 10 microg PAF produced increases in Pto by 10 mmHg and Wt by 35 g/100 g liver weight. This hepatic vasoconstriction was attributed to a threefold increase in the portal vein resistance and a fourfold increase in the hepatic vein resistance. The hepatic arterial resistance was not changed when PAF was arterially or intraportally injected. In conclusion, in isolated perfused dog livers, PAF increases the hepatic capillary pressure and liver weight due to contraction of both the portal vein and hepatic vein, but not the hepatic artery.

publication date

  • September 1, 1997

Research

keywords

  • Blood Pressure
  • Liver
  • Platelet Activating Factor

Identity

Scopus Document Identifier

  • 0030698845

Digital Object Identifier (DOI)

  • 10.1016/s0952-3278(97)90547-0

PubMed ID

  • 9384519

Additional Document Info

volume

  • 57

issue

  • 3