Fatal disseminated intravascular coagulation after autologous islet transplantation. uri icon

Overview

abstract

  • Autologous islet transplantation after pancreatectomy has been used in the surgical management of patients with intractable pain secondary to chronic pancreatitis. Total or near total pancreatectomy invariably leads to exogenous insulin dependence in these patients unless they undergo islet transplantation. Transplantation of autologous islet cells harvested from the patient's pancreas into the liver through portal vein infusion has led to long-term euglycemia in 30% to 50% of patients. We report the development of disseminated intravascular coagulation and fatal hemorrhagic shock in a 36-year-old woman after total pancreatectomy and autologous islet transplantation through retrograde infusion into the splenic vein. We report the clinical and pathological findings and discuss the possible pathophysiological mechanisms involved in the development of disseminated intravascular coagulation after this procedure.

publication date

  • November 1, 1997

Research

keywords

  • Disseminated Intravascular Coagulation
  • Islets of Langerhans Transplantation

Identity

Scopus Document Identifier

  • 0030832761

Digital Object Identifier (DOI)

  • 10.1016/s0046-8177(97)90204-5

PubMed ID

  • 9385936

Additional Document Info

volume

  • 28

issue

  • 11