Persistent antibody responses but declining cytotoxic T-lymphocyte responses to multiple human immunodeficiency virus type 1 antigens in a long-term nonprogressing individual with a defective p17 proviral sequence and no detectable viral RNA expression. Academic Article uri icon

Overview

abstract

  • Long-term nonprogressor AD-18 has been infected with human immunodeficiency virus type 1 (HIV-1) for at least 16 years. During the past 5 years, he has had undetectable levels of plasma viremia, and HIV-1 cannot be isolated from him. Sequencing of proviral DNA indicates that the only HIV-1 sequences that can be identified in AD-18 have gross defects in the p17-encoding regions of the gag gene (Y. Huang, L. Zhang, and D. D. Ho, Virology 240:36-49, 1998). However, AD-18 has strong, sustained antibody responses to several HIV-1 antigens, including p17. Cytotoxic T-lymphocyte responses to Env and Gag antigens have gradually diminished over the past 4 years, at a time when the titers of antibodies to the same proteins have remained stable. We discuss what these observations might mean for the generation and maintenance of immunological memory.

publication date

  • April 1, 1998

Research

keywords

  • Gene Products, gag
  • HIV Antibodies
  • HIV Antigens
  • HIV-1
  • RNA, Viral
  • Sequence Deletion
  • T-Lymphocytes, Cytotoxic
  • Viral Proteins

Identity

PubMed Central ID

  • PMC109859

Scopus Document Identifier

  • 0031900150

Digital Object Identifier (DOI)

  • 10.1128/JVI.72.4.3472-3474.1998

PubMed ID

  • 9525685

Additional Document Info

volume

  • 72

issue

  • 4