Evoked potentials in clinical trials for multiple sclerosis. Review uri icon

Overview

abstract

  • Multiple sclerosis produces disruption of conduction in the central nervous system by a variety of mechanisms, relating, in part, to loss of the myelin sheath. Although often not well correlated with the clinical course of the disease in individual patients, the resulting evoked potential (EP) disturbances can serve as measures of an accumulating disease burden, particularly in longitudinal population studies. Accordingly, EPs can serve as useful instruments for assessing the effectiveness of therapeutic agents which may alter the course of the multiple sclerosis. Furthermore, since EPs measure conduction within the central nervous system, they provide a means of directly assessing symptomatic treatments designed to improve central conduction.

publication date

  • March 1, 1998

Research

keywords

  • Evoked Potentials
  • Multiple Sclerosis

Identity

Scopus Document Identifier

  • 0031869513

Digital Object Identifier (DOI)

  • 10.1097/00004691-199803000-00003

PubMed ID

  • 9563577

Additional Document Info

volume

  • 15

issue

  • 2