Expression patterns of the HIV type 1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood. Academic Article uri icon

Overview

abstract

  • We have measured the surface expression of the HIV-1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood. The expression of CCR5 was largely restricted to the memory (CD45RAlow) subset, whereas CXCR4 was expressed on both memory and naive (CD45RAhigh) T cells. The paucity of memory CD4+ T cells in cord blood means that CCR5-positive cells are relatively uncommon, so the overall extent of CCR5 expression was reduced in cord blood, compared with adult blood. IL-2 activation of CD4+ T cells from both cord and adult bloods caused a substantial increase in CCR5 expression, but moderately decreased CXCR4 expression. PHA stimulation increased CCR5 expression slightly, but only on naive cells. Monocytes expressed both CCR5 and CXCR4 at levels that differed little between cord and adult blood.

publication date

  • May 1, 1998

Research

keywords

  • CD4-Positive T-Lymphocytes
  • Fetal Blood
  • HIV-1
  • Monocytes
  • Receptors, CCR5
  • Receptors, CXCR4

Identity

Scopus Document Identifier

  • 0032080906

Digital Object Identifier (DOI)

  • 10.1089/aid.1998.14.607

PubMed ID

  • 9591715

Additional Document Info

volume

  • 14

issue

  • 7