Perinatal transmission of hepatitis C virus from human immunodeficiency virus type 1-infected mothers. Women and Infants Transmission Study. Academic Article uri icon

Overview

abstract

  • Antepartum plasma hepatitis C virus (HCV) RNA was quantified in 155 mothers coinfected with HCV and human immunodeficiency virus type 1 (HIV-1), and HCV RNA was serially assessed in their infants. Of 155 singleton infants born to HCV antibody-positive mothers, 13 (8.4%) were HCV infected. The risk of HCV infection was 3.2-fold greater in HIV-1-infected infants compared with HIV-1-uninfected infants (17.1% of 41 vs. 5.4% of 112, P = .04). The median concentration of plasma HCV RNA was higher among the 13 mothers with HCV-infected infants (2.0 x 10(6) copies/mL) than among the 142 mothers with HCV-negative infants (3.5 x 10(5) copies/mL; P < .001), and there were no instances of HCV transmission from 40 mothers with HCV RNA concentrations of < 10(5) copies/mL. Women dually infected with HIV-1 and HCV but with little or no detectable HCV RNA should be reassured that the risk of perinatal transmission of HCV is exceedingly low.

publication date

  • June 1, 1998

Research

keywords

  • HIV Infections
  • HIV-1
  • Hepatitis C
  • Infectious Disease Transmission, Vertical
  • Pregnancy Complications, Infectious

Identity

Scopus Document Identifier

  • 17344364927

Digital Object Identifier (DOI)

  • 10.1086/515315

PubMed ID

  • 9607823

Additional Document Info

volume

  • 177

issue

  • 6