Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury. Academic Article uri icon

Overview

abstract

  • Neurotoxic injury of the caudate-putamen and lateral globus pallidus unilaterally initiated transneuronal degeneration of neurons in the ipsilateral substantia nigra reticulata (SNR). Quantification of SNR neurons using unbiased stereology demonstrated that neuron loss began 4 days after the initial striatal lesion, followed by significant loss (50%) at 6 days and a plateau at 8 days. Analysis at the light and ultrastructural levels revealed morphological changes consistent with a type of programmed cell death. These temporal and histological results refine an in vivo model in which to explore mechanisms of delayed neuronal degeneration.

publication date

  • June 8, 1998

Research

keywords

  • Corpus Striatum
  • Nerve Degeneration
  • Substantia Nigra

Identity

Scopus Document Identifier

  • 0032496756

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(98)00247-9

PubMed ID

  • 9622582

Additional Document Info

volume

  • 795

issue

  • 1-2