Duration of neurofibrillary changes in the hippocampal pyramidal neurons. Academic Article uri icon

Overview

abstract

  • The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyrus of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.

publication date

  • July 13, 1998

Research

keywords

  • Alzheimer Disease
  • Hippocampus
  • Neurofibrillary Tangles
  • Pyramidal Cells

Identity

Scopus Document Identifier

  • 0032514269

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(98)00441-7

PubMed ID

  • 9666111

Additional Document Info

volume

  • 799

issue

  • 1