Quantification of myocardial perfusion by MRI after coronary occlusion. Academic Article uri icon

Overview

abstract

  • The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI-derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.

publication date

  • August 1, 1998

Research

keywords

  • Contrast Media
  • Coronary Circulation
  • Gadolinium DTPA
  • Image Enhancement
  • Magnetic Resonance Imaging
  • Myocardial Infarction

Identity

Scopus Document Identifier

  • 7344268000

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910400215

PubMed ID

  • 9702711

Additional Document Info

volume

  • 40

issue

  • 2