Molecular abnormalities in myeloid leukemias and myelodysplastic syndromes.

Overview

Analysis of chromosome translocations in human myeloid leukemias and myelodysplastic syndromes has identified a number of genes involved in the pathogenesis of these diseases. Most of the genes identified to date can be grouped into one of three major classes--transcription factors, tyrosine kinases or nuclear pore proteins. Recent insights into the molecular basis of these leukemias is presented using selected examples from these groups.