Brown, Anthony

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selected publications

Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells. JCI insight. 2022 Academic Article GET IT
Times cited: 3
Correction: Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. The Journal of cell biology. 2021 Academic Article GET IT
Zinc Switch in Pig Heart Lipoamide Dehydrogenase: Steady-State and Transient Kinetic Studies of the Diaphorase Reaction. Biochemistry. Biokhimiia. 2020 Academic Article GET IT
Times cited: 1
Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways. European journal of nutrition. 2018 Academic Article GET IT
Times cited: 32
Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion. Development (Cambridge, England). 2018 Academic Article GET IT
Times cited: 21
Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 15
Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I. PLoS genetics. 2016 Academic Article GET IT
Times cited: 21
Establishing estrogen-responsive mouse mammary organoids from single Lgr5⁺ cells. Cellular signalling. 2016 Academic Article GET IT
Times cited: 30
NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 2015 Academic Article GET IT
Times cited: 99
Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres. PloS one. 2014 Academic Article GET IT
Times cited: 30
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 93
LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure. Human molecular genetics. 2013 Academic Article GET IT
Times cited: 35
Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 14
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 52
Noncanonical Wnt signaling promotes osteoclast differentiation and is facilitated by the human immunodeficiency virus protease inhibitor ritonavir. Biochemical and biophysical research communications. 2011 Academic Article GET IT
Times cited: 42
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 264
Mammary stem cells and cancer: roles of Wnt signaling in plain view. Breast cancer research : BCR. 2010 Academic Article GET IT
Times cited: 8
Wnt signaling in liver cancer. Current drug targets. 2008 Review GET IT
Times cited: 134
GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. Biochemical and biophysical research communications. 2007 Academic Article GET IT
Times cited: 12
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Molecular biology of the cell. 2006 Academic Article GET IT
Times cited: 181
HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer research. 2005 Academic Article GET IT
Times cited: 132
Canonical Wnt signaling: high-throughput RNAi widens the path. Genome biology. 2005 Review GET IT
Times cited: 9
Coordinate regulation of neural tube patterning and proliferation by TGFbeta and WNT activity. Developmental biology. 2004 Academic Article GET IT
Times cited: 121
Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene. 2004 Academic Article GET IT
Times cited: 92
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 143
Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP. Neurobiology of disease. 2004 Academic Article GET IT
Times cited: 11
Wnt proteins in mammary development and cancer. Journal of mammary gland biology and neoplasia. 2004 Review GET IT
Times cited: 207
Wnt signaling and breast cancer. Cancer biology & therapy. 2004 Review GET IT
Times cited: 269
Wnt signalling regulates myogenic differentiation in the developing avian wing. Development (Cambridge, England). 2003 Academic Article GET IT
Times cited: 138
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer research. 2003 Academic Article GET IT
Times cited: 213
Is there a role for Notch signalling in human breast cancer?. Breast cancer research : BCR. 2003 Review GET IT
Times cited: 42
Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 141
Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer. Cancer research. 2002 Academic Article GET IT
Times cited: 201
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 215
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. The Journal of cell biology. 2002 Academic Article GET IT
Times cited: 190
The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis. Cancer research. 2001 Academic Article GET IT
Times cited: 64
Wnt signaling in breast cancer: have we come full circle?. Breast cancer research : BCR. 2001 Review GET IT
Times cited: 123
Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. Endocrine-related cancer. 2001 Review GET IT
Times cited: 306
PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 121
Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency. Oncogene. 2000 Academic Article GET IT
Times cited: 38
Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 167
Wnt-1 dependent activation of the survival factor NF-kappaB in PC12 cells. Journal of neuroscience research. 2000 Academic Article GET IT
Times cited: 95
Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites. Development (Cambridge, England). 2000 Academic Article GET IT
Times cited: 132
Wnt-1 regulation of connexin43 in cardiac myocytes. The Journal of clinical investigation. 2000 Academic Article GET IT
Times cited: 319
Wnt signalling: pathway or network?. Current opinion in genetics & development. 1999 Review GET IT
Times cited: 92
A DLST genotype associated with reduced risk for Alzheimer's disease. Neurology. 1999 Academic Article GET IT
Times cited: 22
Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. Cancer research. 1999 Academic Article GET IT
Times cited: 172
Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. Cancer research. 1999 Academic Article GET IT
Times cited: 153
Wnt signaling stabilizes the dual-function protein beta-catenin in diverse cell types. Annals of the New York Academy of Sciences. 1998 Academic Article GET IT
Times cited: 52
Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. Genomics. 1997 Academic Article GET IT
Times cited: 43
Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1997 Academic Article GET IT
Times cited: 373
Inhibition of chondrogenesis by Wnt gene expression in vivo and in vitro. Developmental biology. 1997 Academic Article GET IT
Times cited: 161
Myogenesis in paraxial mesoderm: preferential induction by dorsal neural tube and by cells expressing Wnt-1. Development (Cambridge, England). 1995 Academic Article GET IT
Times cited: 162
Investigation of the possible role of WNT genes in human breast cancer. Annals of the New York Academy of Sciences. 1995 Academic Article GET IT
Times cited: 7
A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells. Molecular and cellular biology. 1995 Academic Article GET IT
Times cited: 73
The expression pattern of the Distal-less homeobox-containing gene Dlx-5 in the developing chick limb bud suggests its involvement in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Mechanisms of development. 1995 Academic Article GET IT
Times cited: 95
Induction of kidney epithelial morphogenesis by cells expressing Wnt-1. Developmental biology. 1994 Academic Article GET IT
Times cited: 150
Mapping the origin of the avian enteric nervous system with a retroviral marker. Developmental dynamics : an official publication of the American Association of Anatomists. 1994 Academic Article GET IT
Times cited: 76
Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 233
Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes. Mechanisms of development. 1993 Academic Article GET IT
Times cited: 181
Gene transfer of lacZ into avian neural tube and neural crest cells by retroviral infection of grafted embryonic tissues. Journal of neuroscience research. 1993 Academic Article GET IT
Times cited: 11
Wingless, the Drosophila homolog of the proto-oncogene Wnt-1, can transform mouse mammary epithelial cells. Development (Cambridge, England). Supplement. 1993 Academic Article GET IT
Times cited: 23
Cloning and characterization of a novel Drosophila Wnt gene, Dwnt-5, a putative downstream target of the homeobox gene distal-less. Developmental biology. 1992 Academic Article GET IT
Times cited: 43
A spleen necrosis virus-based retroviral vector which expresses two genes from a dicistronic mRNA. Virology. 1992 Academic Article GET IT
Times cited: 35
Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus: I. Formation of the ventricular myocardium. Developmental dynamics : an official publication of the American Association of Anatomists. 1992 Academic Article GET IT
Times cited: 167
The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 136
Spleen necrosis virus, an avian retrovirus, can infect primate cells. Journal of virology. 1991 Academic Article GET IT
Times cited: 29
In vivo analysis of a new lacZ retrovirus vector suitable for cell lineage marking in avian and other species. Experimental cell research. 1991 Academic Article GET IT
Times cited: 114
The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix. The EMBO journal. 1990 Academic Article GET IT
Times cited: 227
A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell. 1986 Academic Article GET IT
Times cited: 141
Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene. Molecular and cellular biology. 1985 Academic Article GET IT
Characterization of IS46, an insertion sequence found on two IncN plasmids. Journal of bacteriology. 1984 Academic Article GET IT
Times cited: 31
A physical and genetic map of the IncN plasmid R46. Plasmid. 1981 Academic Article GET IT
Times cited: 61

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Research

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Funding awarded

Clinical and Translational Science Center - UL1 awarded by National Center for Advancing Translational Sciences Co-Investigator 2022 - 2027

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Background

education and training

Ph.D., University of Edinburgh (United Kingdom) 1981
M.A., Cambridge University (United Kingdom) 1980
B.A., Cambridge University (United Kingdom) 1977

Contact

full name

Anthony Brown

primary email

amcbrown@med.cornell.edu

VIVO Weill Cornell Medical College

Anthony Brown Associate Professor of Cell and Developmental Biology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email