Canonical Wnt signaling: high-throughput RNAi widens the path. Review uri icon

Overview

abstract

  • The canonical Wnt signaling pathway is highly conserved in evolution, widely used throughout animal development, and frequently hyperactive in cancer. Although Wnt signaling has been the subject of extensive genetic analysis in the past, some 200 genes have now been identified as candidate modulators of this pathway by a recent study using high-throughput RNAi screening.

publication date

  • August 31, 2005

Research

keywords

  • RNA Interference
  • Signal Transduction
  • Wnt Proteins

Identity

PubMed Central ID

  • PMC1242201

Scopus Document Identifier

  • 33746040565

Digital Object Identifier (DOI)

  • 10.1083/jcb.200303158

PubMed ID

  • 16168092

Additional Document Info

volume

  • 6

issue

  • 9