Di Lorenzo, Annarita

Publications

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selected publications

Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure. Cardiovascular research. 2023 Academic Article GET IT
Sphingosine-1-phosphate controls endothelial sphingolipid homeostasis via ORMDL. EMBO reports. 2022 Academic Article GET IT
Times cited: 3
Sphingolipid Metabolism and Signaling in Endothelial Cell Functions. Advances in experimental medicine and biology. 2022 Review GET IT
Times cited: 7
Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate. Journal of the American Heart Association. 2021 Academic Article GET IT
Times cited: 14
Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity. Redox biology. 2021 Academic Article GET IT
Times cited: 9
Sphingosine-1-phosphate receptor-1 (S1PR1) signalling: the homeostatic pathway of the heart. Cardiovascular research. 2021 Editorial Article GET IT
Times cited: 2
Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection. Journal of vascular research. 2020 Article GET IT
Times cited: 3
Endothelial Sphingolipid De Novo Synthesis Controls Blood Pressure by Regulating Signal Transduction and NO via Ceramide. Hypertension (Dallas, Tex. : 1979). 2020 Academic Article GET IT
Times cited: 23
Sphingolipid Signature of Human Feto-Placental Vasculature in Preeclampsia. International journal of molecular sciences. 2020 Academic Article GET IT
Times cited: 23
Molecular determinants of nephron vascular specialization in the kidney. Nature communications. 2019 Academic Article GET IT
Times cited: 48
Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach. Interactive cardiovascular and thoracic surgery. 2019 Academic Article GET IT
Times cited: 11
Pressure overload leads to coronary plaque formation, progression, and myocardial events in ApoE-/- mice. JCI insight. 2019 Academic Article GET IT
Times cited: 23
Structural basis of Ca²⁺-dependent activation and lipid transport by a TMEM16 scramblase. eLife. 2019 Academic Article GET IT
Times cited: 68
ADAM10 controls the differentiation of the coronary arterial endothelium. Angiogenesis. 2018 Academic Article GET IT
Times cited: 25
Targeting skeletal endothelium to ameliorate bone loss. Nature medicine. 2018 Academic Article GET IT
Times cited: 165
An engineered S1P chaperone attenuates hypertension and ischemic injury. Science signaling. 2017 Academic Article GET IT
Times cited: 74
S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension (Dallas, Tex. : 1979). 2017 Academic Article GET IT
Times cited: 70
Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. Trends in endocrinology and metabolism: TEM. 2016 Review GET IT
Times cited: 42
S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. The Journal of pharmacology and experimental therapeutics. 2016 Review GET IT
Times cited: 31
Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload. JCI insight. 2016 Academic Article GET IT
Times cited: 105
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Academic Article GET IT
Times cited: 87
Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis--Brief Report. Arteriosclerosis, thrombosis, and vascular biology. 2016 Academic Article GET IT
Times cited: 26
The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Arteriosclerosis, thrombosis, and vascular biology. 2015 Academic Article GET IT
Times cited: 14
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nature medicine. 2015 Academic Article GET IT
Times cited: 75
The role of lipotoxicity in smoke cardiomyopathy. PloS one. 2014 Academic Article GET IT
Times cited: 24
IgE receptor-mediated mast-cell renin release. The American journal of pathology. 2013 Academic Article GET IT
Times cited: 11
eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases. Journal of cell science. 2013 Academic Article GET IT
Times cited: 103
Hypoxia-inducible factor-1α in vascular smooth muscle regulates blood pressure homeostasis through a peroxisome proliferator-activated receptor-γ-angiotensin II receptor type 1 axis. Hypertension (Dallas, Tex. : 1979). 2013 Academic Article GET IT
Times cited: 23
Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 85
Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PloS one. 2011 Academic Article GET IT
Times cited: 106
Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. Blood. 2010 Academic Article GET IT
Times cited: 49
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Molecular cell. 2010 Academic Article GET IT
Times cited: 65
CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. The Journal of clinical investigation. 2010 Academic Article GET IT
Times cited: 121
Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice. Laboratory investigation; a journal of technical methods and pathology. 2010 Academic Article GET IT
Times cited: 9
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 74
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2009 Academic Article GET IT
Times cited: 129
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Science signaling. 2009 Academic Article GET IT
Times cited: 72
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 120
ACE-inhibition ameliorates vascular reactivity and delays diabetes outcome in NOD mice. Vascular pharmacology. 2008 Academic Article GET IT
Times cited: 11
Hydrogen sulphide is involved in testosterone vascular effect. European urology. 2008 Academic Article GET IT
Times cited: 48
Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock. British journal of pharmacology. 2007 Academic Article GET IT
Times cited: 38
Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. American journal of respiratory cell and molecular biology. 2007 Academic Article GET IT
Times cited: 91
Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Academic Article GET IT
Times cited: 34
Proteinase-activated receptor-2 mediates arterial vasodilation in diabetes. Arteriosclerosis, thrombosis, and vascular biology. 2005 Academic Article GET IT
Times cited: 35
Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection. The Journal of pharmacology and experimental therapeutics. 2004 Academic Article GET IT
Times cited: 32
Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arteriosclerosis, thrombosis, and vascular biology. 2004 Academic Article GET IT
Times cited: 55
Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence. The Journal of pharmacology and experimental therapeutics. 2004 Academic Article GET IT
Times cited: 37

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Research

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Funding awarded

Sphingolipid Biology of macrophage in Coronary Atherosclerosis Development and Progression awarded by National Heart, Lung, & Blood Institute Principal Investigator 2021 - 2024
Endothelial Sphingolipid Synthesis and Tissue Inflammatory Response awarded by National Heart, Lung, & Blood Institute Principal Investigator 2019 - 2023

Quantitative susceptibility mapping for stroke risk prediction of vulnerable carotid plaques awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2022 - 2027
Ca2+-dependent lipid scrambling and ion transport by TMEM16 proteins awarded by National Institute of General Medical Sciences Co-Investigator 2019 - 2024

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Background

education and training

Ph.D., University of Naples "Federico II" (Italy) 2004
M.Sc., University of Naples "Federico II" (Italy) 2001

Contact

full name

Annarita Di Lorenzo

primary email

and2039@med.cornell.edu

VIVO Weill Cornell Medical College

Annarita Di Lorenzo Associate Professor of Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email