Kosofsky, Barry

Publications

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selected publications

The Pediatric Neurology 2020 Research Workforce Survey: Optimism in a Time of Challenge. Pediatric neurology. 2020 Academic Article GET IT
Times cited: 1
Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing CLN2. Science translational medicine. 2020 Academic Article GET IT
Times cited: 27
Pediatric Neurology Research in the Twenty-First Century: Status, Challenges, and Future Directions Post-COVID-19. Pediatric neurology. 2020 Academic Article GET IT
Times cited: 4
Autonomic dysfunction following mild traumatic brain injury. Current opinion in neurology. 2019 Review GET IT
Times cited: 10
Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease). Scientific reports. 2018 Academic Article GET IT
Times cited: 14
Disease characteristics and progression in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease: an observational cohort study. The Lancet. Child & adolescent health. 2018 Academic Article GET IT
Times cited: 74
Accuracy of Reported Community Diagnosis of Autism Spectrum Disorder. Journal of psychopathology and behavioral assessment. 2018 Academic Article GET IT
Times cited: 8
Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors. Pediatric neurology. 2017 Academic Article GET IT
Times cited: 18
Neurobehavioral Disorder Associated With Prenatal Alcohol Exposure. Pediatrics. 2016 Academic Article GET IT
Times cited: 36
Guiding Principles for a Pediatric Neurology ICU (neuroPICU) Bedside Multimodal Monitor: Findings from an International Working Group. Applied clinical informatics. 2016 Academic Article GET IT
Times cited: 5
Brain Region-Specific Degeneration with Disease Progression in Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2 Disease). AJNR. American journal of neuroradiology. 2016 Academic Article GET IT
Times cited: 18
Clinical features and biomarkers of concussion and mild traumatic brain injury in pediatric patients. Annals of the New York Academy of Sciences. 2015 Review GET IT
Times cited: 22
Multimodal monitoring in the pediatric intensive care unit: new modalities and informatics challenges. Seminars in pediatric neurology. 2014 Review GET IT
Times cited: 13
Structural brain imaging in children and adolescents following prenatal cocaine exposure: preliminary longitudinal findings. Developmental neuroscience. 2014 Academic Article GET IT
Times cited: 22
Effects of prenatal cocaine exposure on social development in mice. Developmental neuroscience. 2014 Academic Article GET IT
Times cited: 12
Effects of prenatal exposure to cocaine on brain structure and function. Progress in brain research. 2014 Review GET IT
Times cited: 24
Molecular mechanisms mediating a deficit in recall of fear extinction in adult mice exposed to cocaine in utero. PloS one. 2013 Academic Article GET IT
Times cited: 15
Spectrum of ocular manifestations in CLN2-associated batten (Jansky-Bielschowsky) disease correlate with advancing age and deteriorating neurological function. PloS one. 2013 Academic Article GET IT
Times cited: 32
Cup of Joe: a brain development "no"?. Science translational medicine. 2013 Comment GET IT
Times cited: 4
Markers of Celiac Disease and Gluten Sensitivity in Children with Autism. PloS one. 2013 Academic Article GET IT
Times cited: 78
Serologic markers of Lyme disease in children with autism. JAMA. 2013 Academic Article GET IT
Times cited: 6
Regional brain morphometry and impulsivity in adolescents following prenatal exposure to cocaine and tobacco. JAMA pediatrics. 2013 Academic Article GET IT
Times cited: 55
Prenatal-onset neurodevelopmental disorders secondary to toxins, nutritional deficiencies, and maternal illness. Handbook of clinical neurology. 2013 Review GET IT
Times cited: 12
Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis. Human gene therapy methods. 2012 Academic Article GET IT
Times cited: 75
Assessment of disease severity in late infantile neuronal ceroid lipofuscinosis using multiparametric MR imaging. AJNR. American journal of neuroradiology. 2012 Academic Article GET IT
Times cited: 16
Subcortical and cortical structural central nervous system changes and attention processing deficits in preschool-aged children with prenatal methamphetamine and tobacco exposure. Developmental neuroscience. 2012 Academic Article GET IT
Times cited: 50
Brain-derived neurotrophic factor genotype impacts the prenatal cocaine-induced mouse phenotype. Developmental neuroscience. 2012 Academic Article GET IT
Times cited: 13
The rewarding and locomotor-sensitizing effects of repeated cocaine administration are distinct and separable in mice. Neuropharmacology. 2011 Academic Article GET IT
Times cited: 21
Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice. Frontiers in psychiatry. 2011 Academic Article GET IT
Times cited: 8
Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behavioural brain research. 2011 Academic Article GET IT
Times cited: 34
Behavioral epigenetics. Annals of the New York Academy of Sciences. 2011 Academic Article GET IT
Times cited: 108
Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 48
Prenatal L-DOPA exposure produces lasting changes in brain dopamine content, cocaine-induced dopamine release and cocaine conditioned place preference. Neuropharmacology. 2010 Academic Article GET IT
Times cited: 10
Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations. Journal of neurosurgery. Pediatrics. 2010 Academic Article GET IT
Times cited: 56
MELAS with A3243G mutation presenting with occipital status epilepticus. 2009 GET IT
Times cited: 13
Augmentation of cocaine-sensitized dopamine release in the nucleus accumbens of adult mice following prenatal cocaine exposure. Developmental neuroscience. 2009 Academic Article GET IT
Times cited: 10
Neuro-developmental consequences of prenatal drug exposure. Preface. Developmental neuroscience. 2009 Article GET IT
Newborn screening for Krabbe disease: the New York State model. Pediatric neurology. 2009 Academic Article GET IT
Times cited: 159
Neuroimaging of children following prenatal drug exposure. Seminars in cell & developmental biology. 2009 Review GET IT
Times cited: 102
Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. Journal of neurochemistry. 2008 Academic Article GET IT
Times cited: 68
Successful management of refractory neonatal seizures with midazolam. Journal of child neurology. 2008 Academic Article GET IT
Times cited: 21
Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA. Human gene therapy. 2008 Academic Article GET IT
Times cited: 300
Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation. Neurogenetics. 2008 Academic Article GET IT
Times cited: 58
Augmented D1 dopamine receptor signaling and immediate-early gene induction in adult striatum after prenatal cocaine. Biological psychiatry. 2008 Academic Article GET IT
Times cited: 15
NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking. Psychopharmacology. 2007 Academic Article GET IT
Times cited: 61
Three-dimensional high-resolution diffusion tensor imaging and tractography of the developing rabbit brain. Developmental neuroscience. 2007 Academic Article GET IT
Times cited: 33
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. Neurology. 2007 Academic Article GET IT
Times cited: 71
Assessing disease severity in late infantile neuronal ceroid lipofuscinosis using quantitative MR diffusion-weighted imaging. AJNR. American journal of neuroradiology. 2007 Academic Article GET IT
Times cited: 25
Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice. Pharmacology, biochemistry, and behavior. 2007 Academic Article GET IT
Times cited: 27
Prenatal exposure to cocaine increases the rewarding potency of cocaine and selective dopaminergic agonists in adult mice. Biological psychiatry. 2007 Academic Article GET IT
Times cited: 34
Volumetric cerebral characteristics of children exposed to opiates and other substances in utero. NeuroImage. 2007 Academic Article GET IT
Times cited: 119
Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels. Journal of neurochemistry. 2006 Academic Article GET IT
Times cited: 39
Preadolescent methylphenidate versus cocaine treatment differ in the expression of cocaine-induced locomotor sensitization during adolescence and adulthood. Biological psychiatry. 2006 Academic Article GET IT
Times cited: 23
Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge. Journal of neuroscience research. 2006 Academic Article GET IT
Times cited: 48
Psychostimulants, L-type calcium channels, kinases, and phosphatases. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2005 Review GET IT
Times cited: 28
Psychostimulants, Protein phosphorylation and Gene expression: a growing role of L-type calcium channels. Cellscience. 2005 Academic Article GET IT
Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero. Developmental neuroscience. 2005 Academic Article GET IT
Times cited: 17
Patterns of excitotoxin-induced brain lesions in the newborn rabbit: a neuropathological and MRI correlation. Developmental neuroscience. 2005 Academic Article GET IT
Times cited: 19
Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 T. Magnetic resonance in medicine. 2004 Academic Article GET IT
Times cited: 73
L-type Ca2+ channels mediate adaptation of extracellular signal-regulated kinase 1/2 phosphorylation in the ventral tegmental area after chronic amphetamine treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 52
BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Cerebral cortex (New York, N.Y. : 1991). 2004 Academic Article GET IT
Times cited: 104
Cocaine exposure decreases GABA neuron migration from the ganglionic eminence to the cerebral cortex in embryonic mice. Cerebral cortex (New York, N.Y. : 1991). 2004 Academic Article GET IT
Times cited: 64
Methylphenidate and MK-801, an N-methyl-d-aspartate receptor antagonist: shared biological properties. Neuroscience. 2004 Academic Article GET IT
Times cited: 28
Neuropathological consequences of prenatal cocaine exposure in the mouse. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2004 Academic Article GET IT
Times cited: 28
Altered cocaine-induced behavioral sensitization in adult mice exposed to cocaine in utero. Brain research. Developmental brain research. 2003 Academic Article GET IT
Times cited: 39
Does drug abuse beget drug abuse? Behavioral analysis of addiction liability in animal models of prenatal drug exposure. Brain research. Developmental brain research. 2003 Review GET IT
Times cited: 77
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 173
Ventilatory control in newborn mice prenatally exposed to cocaine. Pediatric pulmonology. 2002 Academic Article GET IT
Times cited: 6
Increased vulnerability to self-administer cocaine in mice prenatally exposed to cocaine. Psychopharmacology. 2002 Academic Article GET IT
Times cited: 54
Chronic fluoxetine treatment selectively uncouples raphe 5-HT(1A) receptors as measured by [(35)S]-GTP gamma S autoradiography. British journal of pharmacology. 2002 Academic Article GET IT
Times cited: 62
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Molecular psychiatry. 2001 Academic Article GET IT
Times cited: 28
No time for complacency: the fetal brain on drugs. The Journal of comparative neurology. 2001 Comment GET IT
Times cited: 16
Regional sensitivity and coupling of BOLD and CBV changes during stimulation of rat brain. Magnetic resonance in medicine. 2001 Academic Article GET IT
Times cited: 110
The effect of prenatal cocaine exposure on the stress response of adult mice. Neurotoxicity research. 2001 Academic Article GET IT
Times cited: 7
Developmental considerations of neurotoxic exposures. Neurologic clinics. 2000 Review GET IT
Times cited: 33
Cocaine activation discriminates dopaminergic projections by temporal response: an fMRI study in Rat. NeuroImage. 2000 Academic Article GET IT
Times cited: 154
Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1). Human molecular genetics. 1999 Academic Article GET IT
Times cited: 306
Mechanisms of action of drugs of abuse on the developing fetal brain. Clinics in perinatology. 1999 Review GET IT
Times cited: 83
Multifocal embolic strokes following cardiac surgery in a protein C-deficient child. 1998 GET IT
Times cited: 4
A mouse model of transplacental cocaine exposure. Clinical implications for exposed infants and children. Annals of the New York Academy of Sciences. 1998 Academic Article GET IT
Times cited: 38
A Mouse Model of Transplacental Cocaine Exposure: Clinical Implications for Exposed Infants and Children^a. Annals of the New York Academy of Sciences. 1998 Academic Article GET IT
Times cited: 38
Introduction. Annals of the New York Academy of Sciences. 1998 Academic Article GET IT
Times cited: 1
Preface. Annals of the New York Academy of Sciences. 1998 Academic Article GET IT
Times cited: 5
Round Table 1. Drug Interactions in Cocaine Abuse: Methodologic Concerns in Human and Animal Studies. Annals of the New York Academy of Sciences. 1998 Academic Article GET IT
Round Table 2. Consensus on Postnatal Deficits: Comparability of Human and Animal Findings. Annals of the New York Academy of Sciences. 1998 Academic Article GET IT
Round Table 4. Levels of Vulnerability in Functional Deficits: Specificity of Dysfunctional Brain Systems. Annals of the New York Academy of Sciences. 1998 Academic Article GET IT
Specificity of neurobehavioral outcomes associated with prenatal alcohol exposure. Journal of women's health. 1998 Academic Article GET IT
Times cited: 1
Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magnetic resonance in medicine. 1998 Academic Article GET IT
Times cited: 479
Cocaine-induced alterations in neuro-development. Seminars in speech and language. 1998 Academic Article GET IT
Times cited: 17
Transplacental cocaine exposure. 1: A rodent model. Neurotoxicology and teratology. 1998 Academic Article GET IT
Times cited: 49
Transplacental cocaine exposure. 2: Effects of cocaine dose and gestational timing. Neurotoxicology and teratology. 1998 Academic Article GET IT
Times cited: 26
Transplacental cocaine exposure. 3: Mechanisms underlying altered brain development. Neurotoxicology and teratology. 1998 Academic Article GET IT
Times cited: 28
Acute hydrocephalus following carbon monoxide poisoning. 1997 GET IT
Times cited: 9
Myocyte-specific enhancer binding factor 2C expression in gerbil brain following global cerebral ischemia. Neuroscience. 1996 Academic Article GET IT
Times cited: 15
Cellular localization of dopamine D2 receptor messenger RNA in the rat trigeminal ganglion. Anesthesia and analgesia. 1995 Academic Article GET IT
Times cited: 25
Refined localization of the cerebral cavernous malformation gene (CCM1) to a 4-cM interval of chromosome 7q contained in a well-defined YAC contig. Genome research. 1995 Academic Article GET IT
Times cited: 61
A locus for cerebral cavernous malformations maps to chromosome 7q in two families. Genomics. 1995 Academic Article GET IT
Times cited: 89
Dopamine regulation of transcription factor-target interactions in rat striatum. Chemical senses. 1995 Review GET IT
Times cited: 26
Postnatal age defines specificity of immediate early gene induction by cocaine in developing rat brain. The Journal of comparative neurology. 1995 Academic Article GET IT
Times cited: 44
Substance P phenotype defines specificity of c-fos induction by cocaine in developing rat striatum. The Journal of comparative neurology. 1995 Academic Article GET IT
Times cited: 42
Transplacental cocaine exposure: a mouse model demonstrating neuroanatomic and behavioral abnormalities. Journal of child neurology. 1994 Academic Article GET IT
Times cited: 74
Substance P and substance P receptor histochemistry in human neurodegenerative diseases. Regulatory peptides. 1993 Review GET IT
Times cited: 54
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 187
Everything activates c-fos--how can it matter?. NIDA research monograph. 1993 Review GET IT
Times cited: 17
The ontogeny of immediate early gene response to cocaine: a molecular analysis of the effects of cocaine on developing rat brain. NIDA research monograph. 1993 Review GET IT
Times cited: 6
Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proceedings of the National Academy of Sciences of the United States of America. 1992 Academic Article GET IT
Times cited: 419
Cocaine-induced disturbances of corticogenesis in the developing murine brain. Neuroscience letters. 1992 Academic Article GET IT
Times cited: 115
Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Proceedings of the National Academy of Sciences of the United States of America. 1992 Academic Article GET IT
Times cited: 330
The effect of cocaine on developing human brain. NIDA research monograph. 1991 Review GET IT
Times cited: 17
Wallerian degeneration after cerebral infarction: evaluation with sequential MR imaging. Radiology. 1989 Academic Article GET IT
Times cited: 184
Distribution of locus coeruleus axons in the rat spinal cord: a combined anterograde transport and immunohistochemical study. Brain research. 1987 Academic Article GET IT
Times cited: 66
The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse (New York, N.Y.). 1987 Academic Article GET IT
Times cited: 371
The serotonin and norepinephrine innervation of primary visual cortex in the cynomolgus monkey (Macaca fascicularis). The Journal of comparative neurology. 1984 Academic Article GET IT
Times cited: 72
Control of pattern duplication in the retinotectal system of Xenopus. Suppression of duplication by eye-fragment interactions. Developmental biology. 1979 Academic Article GET IT
Times cited: 16

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Research

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Co-investigator Network

Funding awarded

Child Neurologist Career Development Program (CNCDP) awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2021 - 2023

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Background

education and training

M.D., Ph.D., The Johns Hopkins University School of Medicine 1985
B.A., M.A., The Johns Hopkins University 1978

Contact

full name

Barry Kosofsky

primary email

bar2009@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Barry Kosofsky Professor of Pediatrics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage