Psychostimulants, L-type calcium channels, kinases, and phosphatases. Review uri icon

Overview

abstract

  • There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression. Here the authors will review recent progress in our understanding of L-type Ca2+ channel-activated signal transduction pathways that contribute to molecular neuroadaptations evident following acute and chronic exposures to psychostimulants.

publication date

  • October 1, 2005

Research

keywords

  • Calcium Channels, L-Type
  • Central Nervous System Stimulants
  • Phosphoric Monoester Hydrolases
  • Phosphotransferases
  • Signal Transduction

Identity

PubMed Central ID

  • PMC2706980

Scopus Document Identifier

  • 25144465478

Digital Object Identifier (DOI)

  • 10.1177/1073858405278236

PubMed ID

  • 16151049

Additional Document Info

volume

  • 11

issue

  • 5