Wang, Baolin

Publications

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selected publications

Primary cilia defects causing mitral valve prolapse. Science translational medicine. 2019 Academic Article GET IT
Times cited: 58
Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse. Journal of cell science. 2018 Academic Article GET IT
Times cited: 15
Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Development (Cambridge, England). 2018 Academic Article GET IT
Times cited: 16
Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse. Developmental biology. 2017 Academic Article GET IT
Times cited: 13
Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse. Human molecular genetics. 2017 Academic Article GET IT
Times cited: 17
PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant. Developmental biology. 2017 Academic Article GET IT
Times cited: 19
SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling. Developmental biology. 2016 Academic Article GET IT
Times cited: 9
Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy. The Journal of allergy and clinical immunology. 2016 Academic Article GET IT
Times cited: 18
BMP regulates regional gene expression in the dorsal otocyst through canonical and non-canonical intracellular pathways. Development (Cambridge, England). 2016 Academic Article GET IT
Times cited: 21
Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner. Molecular pharmacology. 2015 Academic Article GET IT
Times cited: 8
Prognostic value of excision repair cross-complementation group 1 expression in gastric cancer: A meta-analysis. Experimental and therapeutic medicine. 2015 Academic Article GET IT
Times cited: 274
ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling. Cell reports. 2014 Academic Article GET IT
Times cited: 10
Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors. PloS one. 2014 Academic Article GET IT
Times cited: 29
Pyrvinium attenuates Hedgehog signaling downstream of smoothened. Cancer research. 2014 Academic Article GET IT
Times cited: 61
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 35
Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants. Developmental biology. 2013 Academic Article GET IT
Times cited: 22
Primary cilia and Gli3 activity regulate cerebral cortical size. Developmental neurobiology. 2012 Academic Article GET IT
Times cited: 55
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling. Developmental biology. 2012 Academic Article GET IT
Times cited: 33
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 20
Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo. Developmental dynamics : an official publication of the American Association of Anatomists. 2011 Academic Article GET IT
Times cited: 15
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Science signaling. 2011 Academic Article GET IT
Times cited: 82
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Disease models & mechanisms. 2010 Academic Article GET IT
Times cited: 64
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development (Cambridge, England). 2010 Academic Article GET IT
Times cited: 162
Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer research. 2010 Academic Article GET IT
Times cited: 49
Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Molecular and cellular biology. 2008 Academic Article GET IT
Times cited: 47
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Developmental biology. 2008 Academic Article GET IT
Times cited: 127
Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Developmental biology. 2008 Academic Article GET IT
Times cited: 95
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 240
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Developmental biology. 2008 Academic Article GET IT
Times cited: 49
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem cells (Dayton, Ohio). 2008 Academic Article GET IT
Times cited: 72
Recombinant BCG coexpressing Ag85B, ESAT-6 and mouse-IFN-gamma confers effective protection against Mycobacterium tuberculosis in C57BL/6 mice. FEMS immunology and medical microbiology. 2007 Academic Article GET IT
Times cited: 37
The molecular basis of Pallister Hall associated polydactyly. Human molecular genetics. 2007 Academic Article GET IT
Times cited: 32
Ftm is a novel basal body protein of cilia involved in Shh signalling. Development (Cambridge, England). 2007 Academic Article GET IT
Times cited: 161
A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype. Developmental dynamics : an official publication of the American Association of Anatomists. 2007 Academic Article GET IT
Times cited: 23
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Developmental biology. 2007 Academic Article GET IT
Times cited: 86
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 114
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Molecular and cellular biology. 2006 Academic Article GET IT
Times cited: 426
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 215
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Developmental biology. 2005 Academic Article GET IT
Times cited: 349
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development (Cambridge, England). 2005 Academic Article GET IT
Times cited: 429
Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv. Protein expression and purification. 2005 Academic Article GET IT
Times cited: 12
Levels of Gli3 repressor correlate with Bmp4 expression and apoptosis during limb development. Developmental dynamics : an official publication of the American Association of Anatomists. 2004 Academic Article GET IT
Times cited: 52
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Molecular cell. 2003 Academic Article GET IT
Times cited: 193
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 2003 Academic Article GET IT
Times cited: 955
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 2000 Academic Article GET IT
Times cited: 1128
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell. 2000 Academic Article GET IT
Times cited: 834
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 152
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell. 1999 Academic Article GET IT
Times cited: 220
Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G. Oncogene. 1998 Academic Article GET IT
Times cited: 71
ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 110
Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk. Oncogene. 1996 Academic Article GET IT
Times cited: 31
Subcellular localization of the Arg protein tyrosine kinase. Oncogene. 1996 Academic Article GET IT
Times cited: 38
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 221
Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. Oncogene. 1996 Academic Article GET IT
Times cited: 30
Large-scale preparation of plasmid DNA by microwave lysis. BioTechniques. 1995 Academic Article GET IT
Times cited: 11
Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43. Gene. 1993 Academic Article GET IT
Times cited: 64

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Research

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Funding awarded

Understanding how ciliary gene mutations affect the processing and activity of Gli2 and Gli3 transcription factors awarded by National Institute of General Medical Sciences Principal Investigator 2021 - 2025

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Background

education and training

Ph.D., University of Pennsylvania 1996
M.S., Fudan University (China) 1985
B.S., Shanghai Normal University (China) 1982

Contact

full name

Baolin Wang

primary email

baw2001@med.cornell.edu

VIVO Weill Cornell Medical College

Baolin Wang Associate Professor of Genetic Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email