Landau, Dan Avi

Publications

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selected publications

Epigenetic dysregulation from chromosomal transit in micronuclei. Nature. 2023 Academic Article GET IT
Times cited: 70
Integration of whole transcriptome spatial profiling with protein markers. Nature biotechnology. 2023 Academic Article GET IT
Times cited: 6
Nanobody-tethered transposition enables multifactorial chromatin profiling at single-cell resolution. Nature biotechnology. 2022 Academic Article GET IT
Times cited: 5
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nature genetics. 2022 Academic Article GET IT
Times cited: 17
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell stem cell. 2022 Academic Article GET IT
Times cited: 12
A BAX door to venetoclax resistance. Blood. 2022 Editorial Article GET IT
Times cited: 3
A heritable, non-genetic road to cancer evolution. Nature. 2022 Comment GET IT
Times cited: 4
Lightning does strike twice: leveraging phased variants to enhance minimal residual disease detection. Med (New York, N.Y.). 2021 Comment GET IT
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states. Nature genetics. 2021 Academic Article GET IT
Times cited: 53
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia. Nature communications. 2021 Academic Article GET IT
Times cited: 12
Smart-RRBS for single-cell methylome and transcriptome analysis. Nature protocols. 2021 Review GET IT
Times cited: 17
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition. Molecular cell. 2021 Academic Article GET IT
Times cited: 36
Discovery of Candidate DNA Methylation Cancer Driver Genes. Cancer discovery. 2021 Academic Article GET IT
Times cited: 26
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics. Nature reviews. Genetics. 2020 Review GET IT
Times cited: 148
Epigenomically Bistable Regions across Neuron-Specific Genes Govern Neuron Eligibility to a Coding Ensemble in the Hippocampus. Cell reports. 2020 Academic Article GET IT
Times cited: 4
Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells. Cell reports. 2020 Academic Article GET IT
Times cited: 20
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring. Nature medicine. 2020 Academic Article GET IT
Times cited: 124
DNA methylation disruption reshapes the hematopoietic differentiation landscape. Nature genetics. 2020 Academic Article GET IT
Times cited: 101
EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation. Genome biology. 2019 Academic Article GET IT
Times cited: 22
Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization. Cell systems. 2019 Academic Article GET IT
Times cited: 9
Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription. Haematologica. 2019 Academic Article GET IT
Times cited: 18
m⁶A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell reports. 2019 Academic Article GET IT
Times cited: 86
Somatic mutations and cell identity linked by Genotyping of Transcriptomes. Nature. 2019 Academic Article GET IT
Times cited: 129
Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia. Nature. 2019 Academic Article GET IT
Times cited: 140
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL. Nature communications. 2019 Academic Article GET IT
Times cited: 46
Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia. Leukemia. 2019 Academic Article GET IT
Times cited: 16
TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics. Molecular cell. 2019 Comment GET IT
Times cited: 3
Discovery of a periosteal stem cell mediating intramembranous bone formation. Nature. 2018 Academic Article GET IT
Times cited: 306
DeTiN: overcoming tumor-in-normal contamination. Nature methods. 2018 Academic Article GET IT
Times cited: 41
The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy. Nature communications. 2017 Academic Article GET IT
Times cited: 113
Cancer Evolution: No Room for Negative Selection. Cell. 2017 Comment GET IT
Times cited: 12
Resistance to checkpoint blockade therapy through inactivation of antigen presentation. Nature communications. 2017 Academic Article GET IT
Times cited: 531
Rare germline variants in ATM are associated with chronic lymphocytic leukemia. Leukemia. 2017 Academic Article GET IT
Times cited: 20
Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution. Cold Spring Harbor perspectives in medicine. 2017 Review GET IT
Times cited: 78
Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia. Cancer cell. 2016 Academic Article GET IT
Times cited: 137
Frequent evolution of copy number alterations in CLL following first-line treatment with FC(R) is enriched with TP53 alterations: results from the CLL8 trial. Leukemia. 2016 Letter GET IT
Times cited: 15
Genomic complexity of multiple myeloma and its clinical implications. Nature reviews. Clinical oncology. 2016 Review GET IT
Times cited: 328
Genetic and epigenetic determinants of B-cell lymphoma evolution. Current opinion in hematology. 2016 Review GET IT
Times cited: 3
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition. 2016 GET IT
Times cited: 247
Mutations driving CLL and their evolution in progression and relapse. Nature. 2015 Academic Article GET IT
Times cited: 721
Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer cell. 2014 Academic Article GET IT
Times cited: 244
Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation: Part I. Biology of relapse after transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Conference Paper GET IT
Times cited: 21
Clonal evolution in hematological malignancies and therapeutic implications. Leukemia. 2013 Review GET IT
Times cited: 119
In vivo activation of transferred regulatory T cells specific for third-party exogenous antigen controls GVH disease in mice. European journal of immunology. 2013 Academic Article GET IT
Times cited: 11
Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013 Academic Article GET IT
Times cited: 3834
Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics. Genome medicine. 2013 Review GET IT
Times cited: 7
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell. 2013 Academic Article GET IT
Times cited: 1066
Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy. Haematologica. 2012 Academic Article GET IT
Times cited: 9
MicroRNAs in mutagenesis, genomic instability, and DNA repair. Seminars in oncology. 2011 Review GET IT
Times cited: 56
Immune reconstitution is preserved in hematopoietic stem cell transplantation coadministered with regulatory T cells for GVHD prevention. Blood. 2010 Academic Article GET IT
Times cited: 45
Regulatory T cell content in the bone marrow graft does not predict the occurrence of acute GVHD. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2010 Academic Article GET IT
Times cited: 19
Causes and predictive factors of mortality in a cohort of patients with hepatitis C virus-related cryoglobulinemic vasculitis treated with antiviral therapy. The Journal of rheumatology. 2010 Academic Article GET IT
Times cited: 52
Role of air-medical evacuation in mass-casualty incidents--a train collision experience. Prehospital and disaster medicine. 2009 Comment GET IT
Times cited: 24
Correlation of clinical and virologic responses to antiviral treatment and regulatory T cell evolution in patients with hepatitis C virus-induced mixed cryoglobulinemia vasculitis. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 35
The prevalence of gastrointestinal diseases in Israeli adolescents and its association with body mass index, gender, and Jewish ethnicity. Journal of clinical gastroenterology. 2008 Academic Article GET IT
Times cited: 19
Detection of occult lung impairment in welders by induced sputum particles and breath oxidation. American journal of industrial medicine. 2008 Academic Article GET IT
Times cited: 40
The B lymphocyte stimulator receptor-ligand system in hepatitis C virus-induced B cell clonal disorders. Annals of the rheumatic diseases. 2008 Academic Article GET IT
Times cited: 41
Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. Blood. 2008 Academic Article GET IT
Times cited: 96
Relapse of hepatitis C virus-associated mixed cryoglobulinemia vasculitis in patients with sustained viral response. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 106
Celiac disease diagnosed in the elderly. 2008 GET IT
Times cited: 48
Physical examination and ECG screening in relation to echocardiography findings in young healthy adults. Cardiology. 2007 Academic Article GET IT
Times cited: 4
Medex test, a novel modality for liver disease diagnosis: a pilot study. Journal of clinical gastroenterology. 2007 Academic Article GET IT
Times cited: 7
Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: where do we stand?. Annals of the rheumatic diseases. 2007 Review GET IT
Times cited: 132
Hepatitis C-associated mixed cryoglobulinaemia: a crossroad between autoimmunity and lymphoproliferation. Rheumatology (Oxford, England). 2007 Review GET IT
Times cited: 122
The pathophysiology of HCV induced B-cell clonal disorders. Autoimmunity reviews. 2007 Review GET IT
Times cited: 72
Acute hepatitis C in Israel: a predominantly iatrogenic disease?. Journal of gastroenterology and hepatology. 2007 Academic Article GET IT
Times cited: 7
Patients' views on optimal visit length in primary care. The Journal of medical practice management : MPM. 2007 Academic Article GET IT
Times cited: 16
Long-term survivors of childhood malignancies--aeromedical dilemmas and implications. Aviation, space, and environmental medicine. 2006 Review GET IT
Times cited: 2
Cervical and lumbar MRI findings in aviators as a function of aircraft type. Aviation, space, and environmental medicine. 2006 Academic Article GET IT
Times cited: 37
Doctors--A species on the verge of extinction? A visit to the 22nd century clinic. Medical hypotheses. 2006 Editorial Article GET IT
PET scan as an aid for the return of a head-injured aviator to flying duty. Aviation, space, and environmental medicine. 2006 Academic Article GET IT
Times cited: 2
Streptococcus bovis bacteremia associated with acute cholecystitis. Journal of clinical gastroenterology. 2006 Letter GET IT
Times cited: 4
Facial nerve palsy after acute exposure to dichloromethane. 2005 GET IT
Times cited: 5
Smoking cessation therapy and the return of aviators to flying duty. Aviation, space, and environmental medicine. 2005 Review GET IT
Times cited: 3

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Research

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Co-investigator Network

Funding awarded

Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy awarded by National Cancer Institute Principal Investigator 2022 - 2027
Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkit awarded by National Heart, Lung, & Blood Institute Principal Investigator 2022 - 2026
Defining the role of DNA methylation modifier mutations in reshaping blood differentiation topology awarded by Leukemia & Lymphoma Society, Inc. Principal Investigator 2021 - 2026
Single-cell multi-omics to link clonal mosaicism (CM) genotypes with chromatin, epigenomic, transcriptomic and protein phenotypes awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2023 - 2025
Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes awarded by National Cancer Institute Principal Investigator 2022 - 2025
Deciphering the fitness determinants of clonal mosaicism awarded by The Mark Foundation for Cancer Research Principal Investigator 2022 - 2024
Deciphering differentiation hierarchies, heritability and plasticity in gliomas via single-cell multi-omics. awarded by Sontag Foundation, Inc. Principal Investigator 2020 - 2024
A multi-omics, single-cell toolkit to study disrupted hematopoietic differentiation in clonal hematopoiesis awarded by Bert L. and N. Kuggie Vallee Foundation, Inc. Principal Investigator 2020 - 2024
Defining Epidrivers of CLL Evolution in Response to Targeted Therapy awarded by National Cancer Institute Principal Investigator 2018 - 2024
Defining the evolutionary mechanisms of IDH-mutant glioma progression through single-cell multi-omics innovation awarded by Starr Cancer Consortium Principal Investigator 2022 - 2023
Understanding and characterizing the role of splicing factor mutations in progression of myeloproliferative neoplasms to accelerated and blast phase awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2021 - 2023
The role of DNA methylation modifiers in shaping the hematopoietic differentiation topology awarded by National Heart, Lung, & Blood Institute Principal Investigator 2019 - 2023
Shapeshifters in Cancer: Defining the Fundamental Forces of Leukemia Evolution awarded by National Cancer Institute Principal Investigator 2018 - 2023
BWF 2015 Career Award for Medical Scientists awarded by Burroughs Wellcome Fund Principal Investigator 2015 - 2023

Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis awarded by National Cancer Institute Co-Investigator 2023 - 2028
Targeting Unmet Needs For B-cell Lymphomas awarded by Leukemia & Lymphoma Society, Inc. Co-Investigator 2022 - 2027
The Immune Niche in the Development of Hematological Malignancies and Implications for Novel Therapy (Core 2: Spatial, Single-cell, and Integrative Informatics and Statistics Core) awarded by Leukemia & Lymphoma Society, Inc. Co-Investigator 2022 - 2027

Multi-Omic and Cellular Trajectories of Clonal Hematopoiesis in Acute Myeloid Leukemia awarded by Daiichi Sankyo, Inc. Key Personnel 2021 - 2023

Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics awarded by Breast Cancer Research Foundation, Inc. Principal Investigator Subaward 2021 - 2026
Developing Novel Therapeutic Approaches for Classical and Variant Hairy Cell Leukemia (Core 2) awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator Subaward 2021 - 2025
Developing Novel Therapeutic Approaches for Classical and Variant Hairy Cell Leukemia (Project 1) awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator Subaward 2021 - 2025
Mosaic: post-zygotic mutations in vascular and lymphatic developmental disorders. awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2020 - 2025
Center for Integrated Cellular Analysis awarded by National Human Genome Research Institute Principal Investigator Subaward 2020 - 2025
Experimental And Preclinical Modeling Of NUP98-Rearranged Acute Leukemia awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2020 - 2024
Genetic Reprogramming of the Solid Tumor Immune Microenvironment awarded by Emerson Collective Cancer Research Fund Principal Investigator Subaward 2021 - 2023
Mechanisms of enhancer regulation in leukemia awarded by National Cancer Institute Principal Investigator Subaward 2019 - 2023

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Background

education and training

Ph.D., University of Paris VII, Denis Diderot (France) 2913
M.D., Sackler School of Medicine, Tel Aviv University (Israel) 2002
B.Sc., Tel Aviv University (Israel) 1998

Contact

full name

Dan Avi Landau

primary email

dal3005@med.cornell.edu

VIVO Weill Cornell Medical College

Dan Avi Landau Assistant Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email