Falcone, Domenick J.

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Retraction: Caloric Restriction Reverses Obesity-Induced Mammary Gland Inflammation in Mice. Cancer prevention research (Philadelphia, Pa.). 2022 Academic Article GET IT
Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women. NPJ breast cancer. 2022 Academic Article GET IT
Times cited: 1256
Correction: Matrix Metalloproteinase-Dependent Microsomal Prostaglandin E Synthase-1 Expression in Macrophages: Role of TNF-α and the EP4 Prostanoid Receptor. Journal of immunology (Baltimore, Md. : 1950). 2021 Academic Article GET IT
Effects of Adiposity and Exercise on Breast Tissue and Systemic Metabo-Inflammatory Factors in Women at High Risk or Diagnosed with Breast Cancer. Cancer prevention research (Philadelphia, Pa.). 2021 Academic Article GET IT
Times cited: 9
Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations. NPJ breast cancer. 2021 Academic Article GET IT
Times cited: 1799
Weill Cornell Medicine. Academic medicine : journal of the Association of American Medical Colleges. 2020 Academic Article GET IT
Supplemental estrogen and caloric restriction reduce obesity-induced periprostatic white adipose inflammation in mice. Carcinogenesis. 2019 Academic Article GET IT
Times cited: 8
Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients. Cancer prevention research (Philadelphia, Pa.). 2018 Academic Article GET IT
Times cited: 10
FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation. JCI insight. 2018 Academic Article GET IT
Times cited: 26
Adiposity, Inflammation, and Breast Cancer Pathogenesis in Asian Women. Cancer prevention research (Philadelphia, Pa.). 2017 Academic Article GET IT
Times cited: 32
Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice. Cancer prevention research (Philadelphia, Pa.). 2017 Academic Article GET IT
Times cited: 14
Periprostatic adipose inflammation is associated with high-grade prostate cancer. Prostate cancer and prostatic diseases. 2017 Academic Article GET IT
Times cited: 54
Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers. The Journal of clinical endocrinology and metabolism. 2017 Academic Article GET IT
Times cited: 65
Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index. Cancer prevention research (Philadelphia, Pa.). 2017 Academic Article GET IT
Times cited: 108
Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation. Journal of lipid research. 2016 Academic Article GET IT
Times cited: 71
Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016 Academic Article GET IT
Times cited: 34
Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice. Cancer prevention research (Philadelphia, Pa.). 2015 Academic Article GET IT
Times cited: 22
Menopause is a determinant of breast adipose inflammation. Cancer prevention research (Philadelphia, Pa.). 2015 Academic Article GET IT
Times cited: 79
IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 99
Caloric restriction reverses obesity-induced mammary gland inflammation in mice. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 47
ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 55
The annexin A2/S100A10 system in health and disease: emerging paradigms. Journal of biomedicine & biotechnology. 2012 Review GET IT
Times cited: 69
Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: role of TNF-α and the EP4 prostanoid receptor. Journal of immunology (Baltimore, Md. : 1950). 2012 Academic Article GET IT
Times cited: 16
Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 371
Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification. Carcinogenesis. 2011 Academic Article GET IT
Times cited: 64
Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: evidence for the role of TNF-alpha and cyclooxygenase-2. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 83
Tobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: evidence for an epidermal growth factor receptor dependent mechanism. Cancer research. 2007 Academic Article GET IT
Times cited: 23
Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 93
Extracellular matrix-induced cyclooxygenase-2 regulates macrophage proteinase expression. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 51
Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages. Blood. 2003 Academic Article GET IT
Times cited: 98
Myocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload. Circulation. 2002 Academic Article GET IT
Times cited: 122
Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 49
A mediator of cell surface-specific plasmin generation. Annals of the New York Academy of Sciences. 2001 Academic Article GET IT
Times cited: 32
Nerve growth factor activation of Erk-1 and Erk-2 induces matrix metalloproteinase-9 expression in vascular smooth muscle cells. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 69
Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II. Blood. 2001 Academic Article GET IT
Times cited: 90
Selective activation of MAPK(erk1/2) by laminin-1 peptide alpha1:Ser(2091)-Arg(2108) regulates macrophage degradative phenotype. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 22
Macrophage formation of angiostatin during inflammation. A byproduct of the activation of plasminogen. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 51
Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 97
Role of laminin in matrix induction of macrophage urokinase-type plasminogen activator and 92-kDa metalloproteinase expression. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 84
Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1. The Journal of clinical investigation. 1995 Academic Article GET IT
Times cited: 171
THP-1 macrophage membrane-bound plasmin activity is up-regulated by transforming growth factor-beta 1 via increased expression of urokinase and the urokinase receptor. Journal of cellular physiology. 1995 Academic Article GET IT
Times cited: 20
Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries. The Journal of clinical investigation. 1995 Academic Article GET IT
Times cited: 52
Regulation of macrophage receptor-bound plasmin by autoproteolysis. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 9
Alpha 2-macroglobulin/transforming growth factor-beta 1 interactions. Modulation by heparin-like molecules and effects on vascular smooth muscle cells. Annals of the New York Academy of Sciences. 1994 Academic Article GET IT
Times cited: 7
Protection of transforming growth factor-beta 1 activity by heparin and fucoidan. Journal of cellular physiology. 1994 Academic Article GET IT
Times cited: 99
Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 113
Transforming growth factor-beta 1 stimulates macrophage urokinase expression and release of matrix-bound basic fibroblast growth factor. Journal of cellular physiology. 1993 Academic Article GET IT
Times cited: 89
Evidence for an age-related dysfunction in the antiproliferative response to transforming growth factor-beta in vascular smooth muscle cells. Molecular biology of the cell. 1993 Academic Article GET IT
Times cited: 62
Transforming growth factor-beta 1 is a heparin-binding protein: identification of putative heparin-binding regions and isolation of heparins with varying affinity for TGF-beta 1. Journal of cellular physiology. 1992 Academic Article GET IT
Times cited: 170
Fucoidan is a non-anticoagulant inhibitor of intimal hyperplasia. Biochemical and biophysical research communications. 1992 Academic Article GET IT
Times cited: 45
Stimulation of macrophage urokinase expression by polyanions is protein kinase C-dependent and requires protein and RNA synthesis. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 39
Activation of platelet heparitinase by tumor cell-derived factors. Blood. 1991 Academic Article GET IT
Times cited: 15
Heparin stimulation of plasminogen activator secretion by macrophage-like cell line RAW264.7: role of the scavenger receptor. Journal of cellular physiology. 1989 Academic Article GET IT
Times cited: 24
Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex. The Journal of cell biology. 1989 Academic Article GET IT
Times cited: 191
Acetyl-LDL stimulates macrophage-dependent plasminogen activation and degradation of extracellular matrix. Journal of cellular physiology. 1988 Academic Article GET IT
Times cited: 33
Fibronectin stimulates macrophage uptake of low density lipoprotein-heparin-collagen complexes. Arteriosclerosis (Dallas, Tex.). 1988 Academic Article GET IT
Times cited: 25
Herpes simplex virus infection in human arterial cells. Implications in arteriosclerosis. The Journal of clinical investigation. 1987 Academic Article GET IT
Times cited: 90
Fluorescent opsonization assay: binding of plasma fibronectin to fibrin-derivatized fluorescent particles does not enhance their uptake by macrophages. Journal of leukocyte biology. 1986 Academic Article GET IT
Times cited: 14
Interaction of arterial cells. I. Endothelial cells alter cholesterol metabolism in co-cultured smooth muscle cells. Journal of lipid research. 1985 Academic Article GET IT
Times cited: 22
Insoluble low-density lipoprotein-proteoglycan complexes enhance cholesteryl ester accumulation in macrophages. The American journal of pathology. 1985 Academic Article GET IT
Times cited: 80
Altered cholesteryl ester cycle is associated with lipid accumulation in herpesvirus-infected arterial smooth muscle cells. The Journal of biological chemistry. 1985 Academic Article GET IT
Times cited: 29
Monocytes and macrophages synthesize and secrete thrombospondin. Blood. 1985 Academic Article GET IT
Times cited: 156
Lipoprotein-heparin-fibronectin-denatured collagen complexes enhance cholesteryl ester accumulation in macrophages. The Journal of cell biology. 1984 Academic Article GET IT
Times cited: 45
Lipoprotein and albumin accumulation in reendothelialized and deendothelialized aorta. The American journal of pathology. 1984 Academic Article GET IT
Times cited: 28
Interactions between prostacyclin metabolism and cholesteryl ester metabolism in the vascular wall. Advances in prostaglandin, thromboxane, and leukotriene research. 1983 Academic Article GET IT
Times cited: 11
Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells. The Journal of clinical investigation. 1982 Academic Article GET IT
Times cited: 105
Diet-induced hypercholesterolemia inhibits the recovery of prostacyclin production by injured rabbit aorta. The American journal of pathology. 1982 Academic Article GET IT
Times cited: 20
Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells. The Journal of clinical investigation. 1981 Academic Article GET IT
Times cited: 128
Endothelium modifies the altered metabolism of the injured aortic wall. The American journal of pathology. 1981 Academic Article GET IT
Times cited: 46
Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta. The American journal of pathology. 1980 Academic Article GET IT
Times cited: 27

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Research

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Funding awarded

Breast White Adipose Tissue Inflammation and Breast Cancer Outcomes awarded by National Cancer Institute Principal Investigator Subaward 2020 - 2025

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Background

education and training

Ph.D., Weill Cornell Graduate School of Medical Sciences 1981
B.A., Queens College, City University of New York 1975

Contact

full name

Domenick J. Falcone

primary email

dfalcone@med.cornell.edu

VIVO Weill Cornell Medical College

Domenick J. Falcone Assistant Dean of Foundational Curriculum

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email