Pitt, Geoffrey

Publications

Sort by

Co-Author Network

selected publications

Increased Ca²⁺ signaling through Ca_V 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 Academic Article GET IT
Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature. 2023 Academic Article GET IT
Times cited: 1
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nature cell biology. 2023 Academic Article GET IT
JACC: Basic to Translational Science Top Reviewers 2022: With Appreciation and Gratitude. JACC. Basic to translational science. 2023 Editorial Article GET IT
Increased Ca ²⁺ signaling through Ca _V 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties. bioRxiv : the preprint server for biology. 2023 Article GET IT
Rad regulation of Ca_V1.2 channels controls cardiac fight-or-flight response. Nature cardiovascular research. 2022 Academic Article GET IT
Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Academic Article GET IT
Times cited: 1
A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells. iScience. 2022 Academic Article GET IT
Times cited: 4613
Increased Ca2+ influx through CaV1.2 drives aortic valve calcification. JCI insight. 2022 Academic Article GET IT
Times cited: 6
Proteolytic regulation of calcium channels - avoiding controversy. Faculty reviews. 2022 Comment GET IT
Times cited: 143
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Circulation research. 2022 Academic Article GET IT
Times cited: 23
JACC: Basic to Translational Science Top Reviewers 2021: With Appreciation. JACC. Basic to translational science. 2022 Editorial Article GET IT
Detecting Cardiovascular Protein-Protein Interactions by Proximity Proteomics. Circulation research. 2022 Review GET IT
Times cited: 2
Correction: Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations. Genetics in medicine : official journal of the American College of Medical Genetics. 2021 Article GET IT
Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors. JCI insight. 2021 Academic Article GET IT
Times cited: 4
Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations. Genetics in medicine : official journal of the American College of Medical Genetics. 2021 Academic Article GET IT
Times cited: 7
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain. Nature communications. 2021 Academic Article GET IT
Times cited: 54
Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na_v1.5. 2020 GET IT
Times cited: 19
Voltage-Gated Calcium Channels in Nonexcitable Tissues. Annual review of physiology. 2020 Review GET IT
Times cited: 23
Adrenergic Ca_V1.2 Activation via Rad Phosphorylation Converges at α_1C I-II Loop. Circulation research. 2020 Academic Article GET IT
Times cited: 23
Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels. JCI insight. 2020 Academic Article GET IT
Times cited: 7
Cardiac phenotype in ATP1A3-related syndromes: A multicenter cohort study. Neurology. 2020 Academic Article GET IT
Times cited: 14
An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF. The Journal of general physiology. 2020 Academic Article GET IT
Times cited: 16
Mechanism of adrenergic Ca_V1.2 stimulation revealed by proximity proteomics. Nature. 2020 Academic Article GET IT
Times cited: 105
Ca²⁺/CaM interaction with voltage-gated Na⁺ channels. Proceedings of the National Academy of Sciences of the United States of America. 2019 Letter GET IT
Times cited: 1
Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Academic Article GET IT
Times cited: 7
The Ca_V1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear. Bone. 2019 Academic Article GET IT
Times cited: 10
Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 37
An update on the journey towards precision medicine in cardiology. European heart journal. 2018 Academic Article GET IT
Times cited: 1
The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 48
Progress in Understanding and Treating SCN2A-Mediated Disorders. Trends in neurosciences. 2018 Review GET IT
Times cited: 151
Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. JCI insight. 2017 Academic Article GET IT
Times cited: 26
Proteolytic cleavage and PKA phosphorylation of α_1C subunit are not required for adrenergic regulation of Ca_V1.2 in the heart. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 25
Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 17
Divide, multitask, and conquer: Coordination in channel regulation. Channels (Austin, Tex.). 2017 Academic Article GET IT
Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. Journal of molecular and cellular cardiology. 2017 Academic Article GET IT
Times cited: 24
Calmodulin limits pathogenic Na+ channel persistent current. The Journal of general physiology. 2017 Academic Article GET IT
Times cited: 41
FGF14 is a regulator of KCNQ2/3 channels. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 29
A view from the side-line. European heart journal. 2016 Academic Article GET IT
Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells. Cell stem cell. 2016 Academic Article GET IT
Times cited: 149
Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins. Protein science : a publication of the Protein Society. 2016 Review GET IT
Times cited: 33
FGF13 modulates the gating properties of the cardiac sodium channel Na_v1.5 in an isoform-specific manner. Channels (Austin, Tex.). 2016 Academic Article GET IT
Times cited: 21
Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action. Proceedings of the National Academy of Sciences of the United States of America. 2016 Comment GET IT
Times cited: 40
α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current. PloS one. 2016 Academic Article GET IT
Times cited: 9
Long QT Syndrome and Seizures. JACC. Clinical electrophysiology. 2016 Editorial Article GET IT
Times cited: 1
A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias. 2016 GET IT
Times cited: 16
STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 38
Genetic variants and disease: correlate or cause?. European heart journal. 2015 Editorial Article GET IT
Times cited: 1
SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 42
Cardiovascular precision medicine: hope or hype?. European heart journal. 2015 Academic Article GET IT
Times cited: 14
Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of physiology. 2015 Review GET IT
Times cited: 49
Calcium Channel Mutations in Cardiac Arrhythmia Syndromes. Current molecular pharmacology. 2015 Review GET IT
Times cited: 38
Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow. Journal of molecular and cellular cardiology. 2014 Academic Article GET IT
Times cited: 10
The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 8
Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2014 Review GET IT
Times cited: 29
FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons. eLife. 2014 Academic Article GET IT
Times cited: 46
Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. Nature communications. 2014 Academic Article GET IT
Times cited: 80
A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis. PloS one. 2014 Academic Article GET IT
Times cited: 37
Ion channels under the sun. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Conference Paper GET IT
Times cited: 4
FGF12 is a candidate Brugada syndrome locus. Heart rhythm. 2013 Academic Article GET IT
Times cited: 73
FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. Cell reports. 2013 Academic Article GET IT
Times cited: 56
Fibroblast growth factor homologous factors modulate cardiac calcium channels. Circulation research. 2013 Academic Article GET IT
Times cited: 47
The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 17
Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 51
Long-term in vivo imaging of multiple organs at the single cell level. PloS one. 2013 Academic Article GET IT
Times cited: 4
Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction. PLoS genetics. 2012 Academic Article GET IT
Times cited: 38
A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. Cell metabolism. 2012 Academic Article GET IT
Times cited: 62
Can polymorphisms predict response to antiarrhythmic drugs in atrial fibrillation?. Journal of the American College of Cardiology. 2012 Editorial Article GET IT
Times cited: 2
Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. Structure (London, England : 1993). 2012 Academic Article GET IT
Times cited: 119
Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. Cell reports. 2012 Academic Article GET IT
Times cited: 152
Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. Trends in cardiovascular medicine. 2011 Review GET IT
Times cited: 13
Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents. PloS one. 2011 Academic Article GET IT
Times cited: 10
Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circulation research. 2011 Academic Article GET IT
Times cited: 88
Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 63
The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction. Circulation. Cardiovascular genetics. 2011 Academic Article GET IT
Times cited: 39
Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation. Heart rhythm. 2010 Academic Article GET IT
Times cited: 7
The glitter of gold: biolistic transfection of fresh adult cardiac myocytes. Focus on "normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method". American journal of physiology. Cell physiology. 2010 Editorial Article GET IT
Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository. American heart journal. 2009 Academic Article GET IT
Times cited: 6
Channeling a new focus for heart failure: insights into ion channels. Journal of cardiovascular pharmacology. 2009 Academic Article GET IT
Times cited: 1
Calcineurin finds a new partner in the L-type Ca2+ channel. Circulation research. 2009 Editorial Article GET IT
Times cited: 2
Accessory subunit KChIP2 modulates the cardiac L-type calcium current. Circulation research. 2009 Academic Article GET IT
Times cited: 69
Genetics of cardiac repolarization. Nature genetics. 2009 Comment GET IT
Times cited: 5
Solution structure of the NaV1.2 C-terminal EF-hand domain. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 39
Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 25
Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Academic Article GET IT
Times cited: 52
Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death. Circulation. 2007 Review GET IT
Times cited: 26
Calmodulin and CaMKII as molecular switches for cardiac ion channels. Cardiovascular research. 2006 Review GET IT
Times cited: 76
Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases. The Journal of general physiology. 2006 Academic Article GET IT
Times cited: 33
Remodeled cardiac calcium channels. Journal of molecular and cellular cardiology. 2006 Review GET IT
Times cited: 44
The real estate of cardiac signaling: location, location, location. Proceedings of the National Academy of Sciences of the United States of America. 2006 Comment GET IT
Times cited: 10
KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. Circulation research. 2006 Academic Article GET IT
Times cited: 137
Aldosterone, ion channels, and sudden death: another piece of the circle?. American journal of physiology. Heart and circulatory physiology. 2006 Editorial Article GET IT
Times cited: 3
CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. The Journal of cell biology. 2005 Academic Article GET IT
Times cited: 272
Essential Ca(V)beta modulatory properties are AID-independent. Nature structural & molecular biology. 2005 Academic Article GET IT
Times cited: 53
Calmodulin mediates Ca2+ sensitivity of sodium channels. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 149
Calcium channel function regulated by the SH3-GK module in beta subunits. Neuron. 2004 Academic Article GET IT
Times cited: 64
Identification of the components controlling inactivation of voltage-gated Ca2+ channels. Neuron. 2004 Academic Article GET IT
Times cited: 137
Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 250
Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 156
Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature. 1999 Academic Article GET IT
Times cited: 744
Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium. Developmental biology. 1997 Academic Article GET IT
Times cited: 74
Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 74
Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). Genes & development. 1993 Academic Article GET IT
Times cited: 78
Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. Molecular biology of the cell. 1992 Academic Article GET IT
Times cited: 44
Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C. Molecular biology of the cell. 1992 Academic Article GET IT
Times cited: 41
Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. Cell. 1992 Academic Article GET IT
Times cited: 265
G-protein-linked signaling pathways mediate development in Dictyostelium. Cold Spring Harbor symposia on quantitative biology. 1992 Review GET IT
Times cited: 13
Mechanisms of excitation and adaptation in Dictyostelium. Seminars in cell biology. 1990 Review GET IT
Times cited: 5
G protein-linked signal transduction in aggregating Dictyostelium. Society of General Physiologists series. 1990 Review GET IT
Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 75
G-protein-linked signal transduction systems control development in Dictyostelium. Development (Cambridge, England). 1989 Academic Article GET IT
Times cited: 8
A simple BASIC program allows the rapid entry of DNA nucleotide sequences into personal computers. BioTechniques. 1988 Academic Article GET IT
A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium. Cold Spring Harbor symposia on quantitative biology. 1988 Academic Article GET IT
Times cited: 14
cAMP receptor and G-protein interactions control development in Dictyostelium. Cold Spring Harbor symposia on quantitative biology. 1988 Academic Article GET IT
Times cited: 13
Development and characterization of a monoclonal antibody to human embryonal carcinoma. The Journal of urology. 1987 Academic Article GET IT
Times cited: 3

more ...

less ...

Research

Sort by

Co-investigator Network

Funding awarded

Multidisciplinary Research Training in Cardiovascular Disease awarded by National Heart, Lung, & Blood Institute Principal Investigator 2022 - 2027
Dynamic changes of the Nav1.5 interactome and contributions to heart failure awarded by National Heart, Lung, & Blood Institute Principal Investigator 2021 - 2025
Investigating the role of CaV1.2 in aortic valve stenosis awarded by National Heart, Lung, & Blood Institute Principal Investigator 2020 - 2024
Molecular and circuit defects underlying different SCN2A mutations and ASDs awarded by National Institute of Mental Health Principal Investigator 2019 - 2024

FGF13 Control of Hippocampal Excitability in Cocaine Contextual Memory awarded by National Institute on Drug Abuse Key Personnel 2022 - 2025

Phosphorylation-dependent regulation of calcium channels by macromolecular complexes awarded by National Institute of Environmental Health Sciences Principal Investigator Subaward 2019 - 2024

more ...

less ...

Background

education and training

M.D., Ph.D., The Johns Hopkins University School of Medicine 1993
Sc.M., The Johns Hopkins University 1987
B.A., Yale University 1984

Contact

full name

Geoffrey Pitt

primary email

geoffrey.pitt@med.cornell.edu

VIVO Weill Cornell Medical College

Geoffrey Pitt Director of the Cardiovascular Research Institute

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email