Iyer, Gopakumar

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selected publications

Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non-Muscle-Invasive Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 3
Clinical and Genomic Characterization of Bladder Carcinomas With Glandular Phenotype. JCO precision oncology. 2022 Academic Article GET IT
Times cited: 1209
Long-term Outcomes of Local and Metastatic Small Cell Carcinoma of the Urinary Bladder and Genomic Analysis of Patients Treated With Neoadjuvant Chemotherapy. Clinical genitourinary cancer. 2022 Academic Article GET IT
Times cited: 1
Correction: Natural history, response to systemic therapy, and genomic landscape of plasmacytoid urothelial carcinoma. British journal of cancer. 2022 Article GET IT
Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma. Nature communications. 2022 Academic Article GET IT
Times cited: 21
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022 Academic Article GET IT
Times cited: 86
Neoadjuvant Atezolizumab With Gemcitabine and Cisplatin in Patients With Muscle-Invasive Bladder Cancer: A Multicenter, Single-Arm, Phase II Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2022 Academic Article GET IT
Times cited: 22
Pre-clinical activity of the oral DNA-PK inhibitor, peposertib (M3814), combined with radiation in xenograft models of cervical cancer. Scientific reports. 2022 Academic Article GET IT
Times cited: 4
CD274 (PD-L1) Copy Number Changes (Gain) & Response to Immune Checkpoint Blockade Therapy in Carcinomas of the Urinary Tract. Bladder cancer (Amsterdam, Netherlands). 2021 Academic Article GET IT
Clinical and Morphologic Characteristics of Fibroblast Growth Factor Receptor Inhibitor-Associated Retinopathy. JAMA ophthalmology. 2021 Academic Article GET IT
Times cited: 2
Pretreatment Eosinophil Counts in Patients With Advanced or Metastatic Urothelial Carcinoma Treated With Anti-PD-1/PD-L1 Checkpoint Inhibitors. Journal of immunotherapy (Hagerstown, Md. : 1997). 2021 Academic Article GET IT
Times cited: 5
LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade. Science translational medicine. 2021 Academic Article GET IT
Times cited: 32
The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia. 2021 GET IT
Times cited: 17
The Genitourinary Pathology Society Update on Classification of Variant Histologies, T1 Substaging, Molecular Taxonomy, and Immunotherapy and PD-L1 Testing Implications of Urothelial Cancers. 2021 GET IT
Times cited: 12
Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS. Nature communications. 2021 Academic Article GET IT
Times cited: 42
Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non-Muscle-Invasive Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 14
Clinical and Morphologic Characteristics of Extracellular Signal-Regulated Kinase Inhibitor-Associated Retinopathy. Ophthalmology. Retina. 2021 Academic Article GET IT
Times cited: 3
Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients. Genome medicine. 2021 Academic Article GET IT
Times cited: 14
Pathological and oncological outcomes in patients with sarcomatoid differentiation undergoing cystectomy. BJU international. 2021 Academic Article GET IT
Times cited: 5
Developing Precision Medicine for Bladder Cancer. Hematology/oncology clinics of North America. 2021 Review GET IT
Times cited: 3
Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 16
Treatment of Metastatic Extramammary Paget Disease with Combination Ipilimumab and Nivolumab: A Case Report. 2021 GET IT
Times cited: 7
Corrigendum re "Fibroblast Growth Factor Receptor 3 Alteration Status is Associated with Differential Sensitivity to Platinum-based Chemotherapy in Locally Advanced and Metastatic Urothelial Carcinoma" [Eur Urol 2020;78:907-15]. European urology. 2021 Article GET IT
OncoTree: A Cancer Classification System for Precision Oncology. JCO clinical cancer informatics. 2021 Academic Article GET IT
Times cited: 22
Natural history, response to systemic therapy, and genomic landscape of plasmacytoid urothelial carcinoma. British journal of cancer. 2021 Academic Article GET IT
Times cited: 9
Lessons from the Study of Exceptional Responders. Cancer cell. 2021 Comment GET IT
Times cited: 1
Noninvasive Detection of Polyclonal Acquired Resistance to FGFR Inhibition in Patients With Cholangiocarcinoma Harboring FGFR2 Alterations. JCO precision oncology. 2021 Academic Article GET IT
Times cited: 19
Genitourinary Medical Oncology Expert Opinion Survey Regarding Treatment Management in the COVID-19 Pandemic. Clinical genitourinary cancer. 2021 Academic Article GET IT
Times cited: 2
A phase II trial of durvalumab and tremelimumab in metastatic, non-urothelial carcinoma of the urinary tract. Cancer medicine. 2020 Academic Article GET IT
Times cited: 6
Systemic therapy in bladder preservation. Urologic oncology. 2020 Review GET IT
Times cited: 3
Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Comment GET IT
Times cited: 9
Re: Russell E.N. Becker, Alexa R. Meyer, Aaron Brant, et al. Clinical Restaging and Tumor Sequencing are Inaccurate Indicators of Response to Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.07.016. European urology. 2020 Letter GET IT
Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Comment GET IT
Times cited: 9
Germ Cell Tumor Molecular Heterogeneity Revealed Through Analysis of Primary and Metastasis Pairs. JCO precision oncology. 2020 Academic Article GET IT
Times cited: 1209
A phase 2 trial of buparlisib in patients with platinum-resistant metastatic urothelial carcinoma. Cancer. 2020 Academic Article GET IT
Times cited: 10
Fibroblast Growth Factor Receptor 3 Alteration Status is Associated with Differential Sensitivity to Platinum-based Chemotherapy in Locally Advanced and Metastatic Urothelial Carcinoma. European urology. 2020 Academic Article GET IT
Times cited: 16
DNA damage repair pathway alterations in metastatic clear cell renal cell carcinoma and implications on systemic therapy. Journal for immunotherapy of cancer. 2020 Academic Article GET IT
Times cited: 27
Emerging biomarkers in urothelial carcinoma: Challenges and opportunities. Cancer treatment and research communications. 2020 Academic Article GET IT
Times cited: 6
Characterization of on-target adverse events caused by TRK inhibitor therapy. Annals of oncology : official journal of the European Society for Medical Oncology. 2020 Academic Article GET IT
Times cited: 26
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts. Nature communications. 2020 Academic Article GET IT
Times cited: 22
Neoadjuvant Gemcitabine-Cisplatin Plus Radical Cystectomy-Pelvic Lymph Node Dissection for Muscle-invasive Bladder Cancer: A 12-year Experience. Clinical genitourinary cancer. 2020 Academic Article GET IT
Times cited: 24
Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models. Scientific reports. 2019 Academic Article GET IT
Times cited: 28
Cancer Susceptibility Mutations in Patients With Urothelial Malignancies. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2019 Academic Article GET IT
Times cited: 47
"Primary" and "secondary" muscle-invasive bladder cancer is more than just a surrogate for molecular subtypes. Translational cancer research. 2019 Academic Article GET IT
Times cited: 542
The landscape of immunotherapy in metastatic urothelial carcinoma. Current opinion in urology. 2019 Review GET IT
Times cited: 4
PD-L1 Expression in Urothelial Carcinoma With Predominant or Pure Variant Histology: Concordance Among 3 Commonly Used and Commercially Available Antibodies. The American journal of surgical pathology. 2019 Academic Article GET IT
Times cited: 50
Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder. The Journal of pathology. 2019 Academic Article GET IT
Times cited: 28
Pembrolizumab in the treatment of locally advanced or metastatic urothelial carcinoma: clinical trial evidence and experience. Therapeutic advances in urology. 2019 Review GET IT
Times cited: 11
MRE11 as a Predictive Biomarker of Outcome After Radiation Therapy in Bladder Cancer. International journal of radiation oncology, biology, physics. 2019 Academic Article GET IT
Times cited: 23
Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers. Nature. 2019 Academic Article GET IT
Times cited: 6
Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nature genetics. 2019 Academic Article GET IT
Times cited: 1996
Novel therapies in urothelial carcinoma: a biomarker-driven approach. Annals of oncology : official journal of the European Society for Medical Oncology. 2018 Academic Article GET IT
Times cited: 7
Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 130
Updates on the Genetics and Molecular Subtypes of Urothelial Carcinoma and Select Variants. Surgical pathology clinics. 2018 Review GET IT
Times cited: 21
Genomic Differences Between "Primary" and "Secondary" Muscle-invasive Bladder Cancer as a Basis for Disparate Outcomes to Cisplatin-based Neoadjuvant Chemotherapy. European urology. 2018 Academic Article GET IT
Times cited: 92
Durable response to anti-PD-1 immunotherapy in epithelioid angiomyolipoma: a report on the successful treatment of a rare malignancy. 2018 GET IT
Times cited: 16
Low-Grade Serous Ovarian Cancer: Current Treatment Paradigms and Future Directions. Current treatment options in oncology. 2018 Review GET IT
Times cited: 13
Genome doubling shapes the evolution and prognosis of advanced cancers. Nature genetics. 2018 Academic Article GET IT
Times cited: 268
ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 83
Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus. Oncotarget. 2018 Academic Article GET IT
Times cited: 21
Commentary on "DNA damage response and repair gene alterations are associated with improved survival in patients with platinum-treated advanced urothelial carcinoma.". Urologic oncology. 2018 Comment GET IT
Times cited: 1
Multicenter Prospective Phase II Trial of Neoadjuvant Dose-Dense Gemcitabine Plus Cisplatin in Patients With Muscle-Invasive Bladder Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Academic Article GET IT
Times cited: 94
Intratumoral heterogeneity of ERBB2 amplification and HER2 expression in micropapillary urothelial carcinoma. Human pathology. 2018 Academic Article GET IT
Times cited: 25
Alterations in DNA Damage Response and Repair Genes as Potential Marker of Clinical Benefit From PD-1/PD-L1 Blockade in Advanced Urothelial Cancers. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Academic Article GET IT
Times cited: 343
Novel biomarkers in bladder cancer. Urologic oncology. 2018 Review GET IT
Times cited: 6
Genomic Profile of Urothelial Carcinoma of the Upper Tract from Ureteroscopic Biopsy: Feasibility and Validation Using Matched Radical Nephroureterectomy Specimens. European urology focus. 2018 Academic Article GET IT
Times cited: 19
HER kinase inhibition in patients with HER2- and HER3-mutant cancers. Nature. 2018 Academic Article GET IT
Times cited: 473
Genomic Characterization of Upper-Tract Urothelial Carcinoma in Patients With Lynch Syndrome. JCO precision oncology. 2018 Academic Article GET IT
Times cited: 29
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer. Nature communications. 2017 Academic Article GET IT
Times cited: 77
Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Academic Article GET IT
Times cited: 67
Granuloma annulare associated with immune checkpoint inhibitors. Journal of the European Academy of Dermatology and Venereology : JEADV. 2017 Letter GET IT
Times cited: 19
Activating mutation of PDGFRB gene in a rare cardiac undifferentiated intimal sarcoma of the left atrium: a case report. Oncotarget. 2017 Academic Article GET IT
Times cited: 10
Incidence and Effect of Thromboembolic Events in Radical Cystectomy Patients Undergoing Preoperative Chemotherapy for Muscle-invasive Bladder Cancer. Clinical genitourinary cancer. 2017 Academic Article GET IT
Times cited: 8
Prognostic Value of TERT Alterations, Mutational and Copy Number Alterations Burden in Urothelial Carcinoma. European urology focus. 2017 Letter GET IT
Times cited: 24
Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nature medicine. 2017 Academic Article GET IT
Times cited: 30
Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets. European urology. 2017 Academic Article GET IT
Times cited: 217
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis. PLoS medicine. 2017 Academic Article GET IT
Times cited: 209
OncoKB: A Precision Oncology Knowledge Base. JCO precision oncology. 2017 Academic Article GET IT
Times cited: 394
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nature medicine. 2017 Academic Article GET IT
Times cited: 1922
Next-generation sequencing of urine specimens: A novel platform for genomic analysis in patients with non-muscle-invasive urothelial carcinoma treated with bacille Calmette-Guérin. Cancer cytopathology. 2017 Academic Article GET IT
Times cited: 24
A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel. Investigational new drugs. 2017 Academic Article GET IT
Times cited: 10
DNA Damage Response and Repair Gene Alterations Are Associated with Improved Survival in Patients with Platinum-Treated Advanced Urothelial Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Academic Article GET IT
Times cited: 183
ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer. Cancer research. 2017 Academic Article GET IT
Times cited: 14
Editorial Comment. Urology. 2016 Comment GET IT
Tumor Inhibition by Enzalutamide in a Xenograft Model of Ovarian Cancer. Cancer investigation. 2016 Academic Article GET IT
Times cited: 10
Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Academic Article GET IT
Times cited: 121
Genomic characterization of response to chemoradiation in urothelial bladder cancer. Cancer. 2016 Academic Article GET IT
Times cited: 46
Urachal Carcinoma Shares Genomic Alterations with Colorectal Carcinoma and May Respond to Epidermal Growth Factor Inhibition. European urology. 2016 Academic Article GET IT
Times cited: 56
Collaborating to Move Research Forward: Proceedings of the 10th Annual Bladder Cancer Think Tank. Bladder cancer (Amsterdam, Netherlands). 2016 Academic Article GET IT
Times cited: 1584
Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer. Nature genetics. 2016 Academic Article GET IT
Times cited: 118
Genomic Biomarkers for the Prediction of Stage and Prognosis of Upper Tract Urothelial Carcinoma. The Journal of urology. 2016 Academic Article GET IT
Times cited: 32
Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer. 2015 GET IT
Times cited: 76
Genomic Characterization of Upper Tract Urothelial Carcinoma. European urology. 2015 Academic Article GET IT
Times cited: 165
Molecular Signature of Response to Pazopanib Salvage Therapy for Urothelial Carcinoma. Clinical genitourinary cancer. 2015 Academic Article GET IT
Times cited: 3
DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors. BMC cancer. 2015 Academic Article GET IT
Times cited: 20
The safety and efficacy of single-agent pemetrexed in platinum-resistant advanced urothelial carcinoma: a large single-institution experience. The oncologist. 2015 Academic Article GET IT
Times cited: 36
Targeted therapy in advanced bladder cancer: what have we learned?. The Urologic clinics of North America. 2015 Review GET IT
Times cited: 13
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor. Nature. 2014 Academic Article GET IT
Times cited: 396
Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma. Cancer discovery. 2014 Academic Article GET IT
Times cited: 438
Genomic predictors of survival in patients with high-grade urothelial carcinoma of the bladder. European urology. 2014 Academic Article GET IT
Times cited: 110
Bevacizumab shows activity in patients with low-grade serous ovarian and primary peritoneal cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2014 Academic Article GET IT
Times cited: 66
Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy. Cancer discovery. 2014 Academic Article GET IT
Times cited: 97
Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Academic Article GET IT
Times cited: 79
Targeted therapies for treatment of recurrent ovarian cancer. Clinical advances in hematology & oncology : H&O. 2014 Review GET IT
Times cited: 12
Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 622
Germline single nucleotide polymorphisms associated with response of urothelial carcinoma to platinum-based therapy: the role of the host. Annals of oncology : official journal of the European Society for Medical Oncology. 2013 Academic Article GET IT
Times cited: 9
Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2013 Academic Article GET IT
Times cited: 240
Phase II study of everolimus in metastatic urothelial cancer. BJU international. 2013 Academic Article GET IT
Times cited: 144
Specific PPAR gamma agonists may have different effects on cancer incidence. Annals of oncology : official journal of the European Society for Medical Oncology. 2013 Letter GET IT
Times cited: 4
Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells. Cancer research. 2013 Academic Article GET IT
Times cited: 71
BRAF mutation is associated with early stage disease and improved outcome in patients with low-grade serous ovarian cancer. Cancer. 2012 Academic Article GET IT
Times cited: 147
Genome sequencing identifies a basis for everolimus sensitivity. Science (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 578
Fibroblast growth factor receptor-3 in urothelial tumorigenesis. Urologic oncology. 2012 Review GET IT
Times cited: 48
A phase I trial of docetaxel and pulse-dose 17-allylamino-17-demethoxygeldanamycin in adult patients with solid tumors. Cancer chemotherapy and pharmacology. 2011 Academic Article GET IT
Times cited: 28
Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma. The Journal of pathology. 2011 Academic Article GET IT
Times cited: 71
Novel strategies for treating relapsed/refractory urothelial carcinoma. Expert review of anticancer therapy. 2010 Review GET IT
Times cited: 12

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Background

education and training

M.D., Vanderbilt University School of Medicine 2003
B.S., Vanderbilt University 1998

Contact

full name

Gopakumar Iyer

VIVO Weill Cornell Medical College

Gopakumar Iyer Associate Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

Phone

Publications

selected publications

Background

education and training

Contact

full name