Updates on the Genetics and Molecular Subtypes of Urothelial Carcinoma and Select Variants. Review uri icon

Overview

abstract

  • Urothelial carcinoma is a morphologically and genomically heterogeneous disease that exhibits a wide spectrum of morphologic features and molecular alterations and subtypes. Classic urothelial carcinoma (not otherwise specified) is the most common tumor type that develops in the urinary bladder but many, well-documented, variant histologies are commonly encountered in approximately one-third of invasive urothelial carcinoma, including squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. In this review, we provide an update on the molecular advances in urothelial carcinoma and some of its variant histologies.

publication date

  • October 17, 2018

Research

keywords

  • Carcinoma
  • Urinary Bladder Neoplasms
  • Urothelium

Identity

PubMed Central ID

  • PMC6768438

Scopus Document Identifier

  • 85054823768

Digital Object Identifier (DOI)

  • 10.1016/j.path.2018.07.011

PubMed ID

  • 30447837

Additional Document Info

volume

  • 11

issue

  • 4