Weinstein, Harel

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Allosterically coupled conformational dynamics in solution prepare the sterol transfer protein StarD4 to release its cargo upon interaction with target membranes. Frontiers in molecular biosciences. 2023 Academic Article GET IT
Times cited: 138
Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV). bioRxiv : the preprint server for biology. 2023 Article GET IT
Times cited: 12
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Science signaling. 2022 Academic Article GET IT
Times cited: 8
Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path. ACS bio & med chem Au. 2022 Academic Article GET IT
Times cited: 195
The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase. Communications biology. 2022 Academic Article GET IT
Times cited: 3
Molecular determinants of pH sensing in the proton-activated chloride channel. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 5
The permeation of potassium ions through the lipid scrambling path of the membrane protein nhTMEM16. Frontiers in molecular biosciences. 2022 Academic Article GET IT
Times cited: 306
Phosphatidylinositol phosphates modulate interactions between the StarD4 sterol trafficking protein and lipid membranes. The Journal of biological chemistry. 2022 Academic Article GET IT
Times cited: 3
Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl^-/H⁺ Antiporter. Molecules (Basel, Switzerland). 2021 Academic Article GET IT
Times cited: 4
A Graphic Encoding Method for Quantitative Classification of Protein Structure and Representation of Conformational Changes. IEEE/ACM transactions on computational biology and bioinformatics. 2021 Academic Article GET IT
Times cited: 2
Localization atomic force microscopy. Nature. 2021 Academic Article GET IT
Times cited: 61
Ligand-Dependent Conformational Transitions in Molecular Dynamics Trajectories of GPCRs Revealed by a New Machine Learning Rare Event Detection Protocol. Molecules (Basel, Switzerland). 2021 Academic Article GET IT
Times cited: 4
Ca²⁺-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide. Biophysical journal. 2021 Academic Article GET IT
Times cited: 30
Ca ²⁺ -dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide. bioRxiv : the preprint server for biology. 2021 Article GET IT
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro. bioRxiv : the preprint server for biology. 2020 Article GET IT
Publisher Correction: GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature methods. 2020 Article GET IT
Times cited: 1
GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature methods. 2020 Academic Article GET IT
Times cited: 60
Use of paramagnetic ¹⁹F NMR to monitor domain movement in a glutamate transporter homolog. Nature chemical biology. 2020 Academic Article GET IT
Times cited: 23
Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 Academic Article GET IT
Times cited: 18
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature communications. 2020 Academic Article GET IT
Times cited: 22
Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins. Journal of computational chemistry. 2019 Academic Article GET IT
Times cited: 11
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca²⁺-bound nhTMEM16. Nature communications. 2019 Academic Article GET IT
Times cited: 18
A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited. Biophysical journal. 2019 Article GET IT
Times cited: 1
The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 18
A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs. Molecules (Basel, Switzerland). 2019 Academic Article GET IT
Times cited: 30
Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles. Biophysical journal. 2019 Academic Article GET IT
Times cited: 34
A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited. Biophysical journal. 2019 Academic Article GET IT
Times cited: 42
Accurate In Silico Modeling of Asymmetric Bilayers Based on Biophysical Principles. Biophysical journal. 2018 Academic Article GET IT
Times cited: 28
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase. Nature communications. 2018 Academic Article GET IT
Times cited: 52
The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 14
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1. Cell reports. 2018 Academic Article GET IT
Times cited: 31
How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties. BMC biology. 2018 Academic Article GET IT
Times cited: 27
A partially-open inward-facing intermediate conformation of LeuT is associated with Na⁺ release and substrate transport. Nature communications. 2018 Academic Article GET IT
Times cited: 31
Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin. Structure (London, England : 1993). 2017 Academic Article GET IT
Times cited: 38
Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter. Biophysical journal. 2017 Academic Article GET IT
Times cited: 13
Single-molecule analysis of ligand efficacy in β₂AR-G-protein activation. Nature. 2017 Academic Article GET IT
Times cited: 200
Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins. Frontiers in molecular neuroscience. 2017 Academic Article GET IT
Times cited: 55
The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state. The Journal of biological chemistry. 2017 Academic Article GET IT
Times cited: 18
Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis. Journal of cell science. 2017 Academic Article GET IT
Times cited: 31
A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter. Scientific reports. 2017 Academic Article GET IT
Times cited: 52
Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances - The case of the benzofuran 5-MAPB. Progress in neuro-psychopharmacology & biological psychiatry. 2016 Academic Article GET IT
Times cited: 14
The Allostery Landscape: Quantifying Thermodynamic Couplings in Biomolecular Systems. Journal of chemical theory and computation. 2016 Academic Article GET IT
Times cited: 24
Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 16
Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nature communications. 2016 Academic Article GET IT
Times cited: 107
Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters. Chemical reviews. 2016 Review GET IT
Times cited: 57
Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles. Biochemistry. 2016 Academic Article GET IT
Times cited: 11
Computational approaches to detect allosteric pathways in transmembrane molecular machines. Biochimica et biophysica acta. 2016 Academic Article GET IT
Times cited: 41
A GIPC1-Palmitate Switch Modulates Dopamine Drd3 Receptor Trafficking and Signaling. Molecular and cellular biology. 2016 Academic Article GET IT
Times cited: 12
Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 29
Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus. ACS chemical neuroscience. 2015 Academic Article GET IT
Times cited: 78
Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering. Structure (London, England : 1993). 2015 Academic Article GET IT
Times cited: 29
AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems. Entropy (Basel, Switzerland). 2015 Academic Article GET IT
Times cited: 15
Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 40
Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops. Biochimica et biophysica acta. 2015 Review GET IT
Times cited: 22
Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes. Proteins. 2015 Academic Article GET IT
Times cited: 39
Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature. 2015 Academic Article GET IT
Times cited: 122
A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain. Biochimica et biophysica acta. 2015 Academic Article GET IT
Times cited: 34
A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 60
ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling. Cell reports. 2014 Academic Article GET IT
Times cited: 10
The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 31
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. 2014 GET IT
Times cited: 103
Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins. Biophysical journal. 2014 Review GET IT
Times cited: 43
PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. Nature chemical biology. 2014 Academic Article GET IT
Times cited: 91
NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT. PLoS computational biology. 2014 Academic Article GET IT
Times cited: 76
Conformational dynamics of ligand-dependent alternating access in LeuT. Nature structural & molecular biology. 2014 Academic Article GET IT
Times cited: 110
Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry international. 2014 Academic Article GET IT
Times cited: 13
Protein and lipid interactions driving molecular mechanisms of in meso crystallization. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 17
How the dynamic properties and functional mechanisms of GPCRs are modulated by their coupling to the membrane environment. Advances in experimental medicine and biology. 2014 Review GET IT
Times cited: 19
Membrane driven spatial organization of GPCRs. Scientific reports. 2013 Academic Article GET IT
Times cited: 92
The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 29
Turkey must end violent response to protests. Science (New York, N.Y.). 2013 Letter GET IT
Times cited: 1
Chloride binding site of neurotransmitter sodium symporters. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 68
The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT. Chemistry and physics of lipids. 2013 Academic Article GET IT
Times cited: 36
Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 75
Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure. Biochemistry. 2012 Academic Article GET IT
Times cited: 25
Why GPCRs behave differently in cubic and lamellar lipidic mesophases. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 43
Ion-controlled conformational dynamics in the outward-open transition from an occluded state of LeuT. Biophysical journal. 2012 Academic Article GET IT
Times cited: 75
In support of the BMRB. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 5
Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh. The journal of physical chemistry. B. 2012 Academic Article GET IT
Times cited: 37
Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties. PLoS computational biology. 2012 Academic Article GET IT
Times cited: 92
Experimental conditions can obscure the second high-affinity site in LeuT. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 77
Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors. Biophysical journal. 2011 Academic Article GET IT
Times cited: 77
The correlation between multidomain enzymes and multiple activation mechanisms--the case of phospholipase Cβ and its membrane interactions. Biochimica et biophysica acta. 2011 Review GET IT
Times cited: 6
A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits. Molecular pharmacology. 2011 Academic Article GET IT
Times cited: 17
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature. 2011 Academic Article GET IT
Times cited: 192
The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PloS one. 2011 Academic Article GET IT
Times cited: 101
Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms. Biophysical journal. 2010 Academic Article GET IT
Times cited: 40
Probing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors. Biochemistry. 2010 Academic Article GET IT
Times cited: 18
PDZ binding to the BAR domain of PICK1 is elucidated by coarse-grained molecular dynamics. Journal of molecular biology. 2010 Academic Article GET IT
Times cited: 33
Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors. The journal of physical chemistry. B. 2010 Academic Article GET IT
Times cited: 26
The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 2010 Academic Article GET IT
Times cited: 55
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. Organic & biomolecular chemistry. 2010 Academic Article GET IT
Times cited: 30
Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nature structural & molecular biology. 2010 Academic Article GET IT
Times cited: 158
Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature. 2010 Academic Article GET IT
Times cited: 208
Substrate-dependent proton antiport in neurotransmitter:sodium symporters. Nature chemical biology. 2009 Academic Article GET IT
Times cited: 42
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 95
Modeling membrane deformations and lipid demixing upon protein-membrane interaction: the BAR dimer adsorption. Biophysical journal. 2009 Academic Article GET IT
Times cited: 56
Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nature chemical biology. 2009 Academic Article GET IT
Times cited: 301
Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations. Proteins. 2009 Academic Article GET IT
Times cited: 105
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 148
A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation. Molecular pharmacology. 2008 Academic Article GET IT
Times cited: 61
Ligand selectivity of D2 dopamine receptors is modulated by changes in local dynamics produced by sodium binding. The Journal of pharmacology and experimental therapeutics. 2008 Academic Article GET IT
Times cited: 27
Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation. Neuropharmacology. 2008 Academic Article GET IT
Times cited: 20
The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature neuroscience. 2008 Academic Article GET IT
Times cited: 271
The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site. Molecular cell. 2008 Academic Article GET IT
Times cited: 307
Active state-like conformational elements in the beta2-AR and a photoactivated intermediate of rhodopsin identified by dynamic properties of GPCRs. Biochemistry. 2008 Academic Article GET IT
Times cited: 20
Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (Copenhagen, Denmark). 2008 Academic Article GET IT
Times cited: 42
Identification of GATC- and CCGG-recognizing Type II REases and their putative specificity-determining positions using Scan2S--a novel motif scan algorithm with optional secondary structure constraints. Proteins. 2008 Academic Article GET IT
Times cited: 4
An intracellular interaction network regulates conformational transitions in the dopamine transporter. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 108
Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia. Cancer prevention research (Philadelphia, Pa.). 2008 Academic Article GET IT
Times cited: 53
Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework. Biophysical journal. 2008 Academic Article GET IT
Times cited: 24
Protein diffusion on charged membranes: a dynamic mean-field model describes time evolution and lipid reorganization. Biophysical journal. 2007 Academic Article GET IT
Times cited: 46
Toward realistic modeling of dynamic processes in cell signaling: quantification of macromolecular crowding effects. The Journal of chemical physics. 2007 Academic Article GET IT
Times cited: 57
Topology of Type II REases revisited; structural classes and the common conserved core. Nucleic acids research. 2007 Academic Article GET IT
Times cited: 31
Modeling activated states of GPCRs: the rhodopsin template. Journal of computer-aided molecular design. 2006 Academic Article GET IT
Times cited: 64
Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer. Journal of computer-aided molecular design. 2006 Academic Article GET IT
Times cited: 68
Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study. Journal of the American Chemical Society. 2006 Academic Article GET IT
Times cited: 102
Ab initio computational modeling of loops in G-protein-coupled receptors: lessons from the crystal structure of rhodopsin. Proteins. 2006 Academic Article GET IT
Times cited: 38
A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Molecular pharmacology. 2006 Academic Article GET IT
Times cited: 233
Functional selectivity and classical concepts of quantitative pharmacology. The Journal of pharmacology and experimental therapeutics. 2006 Review GET IT
Times cited: 909
State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 81
Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways. Gastroenterology. 2006 Academic Article GET IT
Times cited: 36
Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors. The AAPS journal. 2006 Review GET IT
Times cited: 29
Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 252
A flexible docking procedure for the exploration of peptide binding selectivity to known structures and homology models of PDZ domains. Journal of the American Chemical Society. 2005 Academic Article GET IT
Times cited: 66
A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding. Neuropharmacology. 2005 Academic Article GET IT
Times cited: 38
The structure and dynamics of GPCR oligomers: a new focus in models of cell-signaling mechanisms and drug design. Current opinion in drug discovery & development. 2005 Review GET IT
Times cited: 36
Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 84
The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics. The FEBS journal. 2005 Review GET IT
Times cited: 94
Modeling membrane proteins based on low-resolution electron microscopy maps: a template for the TM domains of the oxalate transporter OxlT. Protein engineering, design & selection : PEDS. 2005 Academic Article GET IT
Times cited: 15
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 70
PDZBase: a protein-protein interaction database for PDZ-domains. Bioinformatics (Oxford, England). 2004 Academic Article GET IT
Times cited: 159
Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. Molecular pharmacology. 2004 Academic Article GET IT
Times cited: 35
Quantitative information management for the biochemical computation of cellular networks. Science's STKE : signal transduction knowledge environment. 2004 Academic Article GET IT
Times cited: 32
Molecular dynamics simulations of transducin: interdomain and front to back communication in activation and nucleotide exchange. Journal of molecular biology. 2004 Academic Article GET IT
Times cited: 38
Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 9
A knowledge-based scale for the analysis and prediction of buried and exposed faces of transmembrane domain proteins. Bioinformatics (Oxford, England). 2004 Academic Article GET IT
Times cited: 63
Probing conformational changes in neurotransmitter transporters: a structural context. European journal of pharmacology. 2003 Review GET IT
Times cited: 40
Batch mode generation of residue-based diagrams of proteins. Bioinformatics (Oxford, England). 2003 Academic Article GET IT
Times cited: 8
Building protein diagrams on the web with the residue-based diagram editor RbDe. Nucleic acids research. 2003 Academic Article GET IT
Times cited: 23
A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P. Biochemistry. 2003 Academic Article GET IT
Times cited: 7
Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex. Biophysical journal. 2003 Academic Article GET IT
Times cited: 27
Molecular dynamics simulations of peptides and proteins with a continuum electrostatic model based on screened Coulomb potentials. Proteins. 2003 Academic Article GET IT
Times cited: 62
Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy. Molecular pharmacology. 2003 Academic Article GET IT
Times cited: 63
Key issues in the computational simulation of GPCR function: representation of loop domains. Journal of computer-aided molecular design. 2002 Academic Article GET IT
Times cited: 52
Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein engineering. 2002 Academic Article GET IT
Times cited: 78
The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the mu opioid receptor and reduces the constitutive activity of its T6.34(279)K mutant. Biochemistry. 2002 Academic Article GET IT
Times cited: 31
Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 105
Structural mimicry of proline kinks: tertiary packing interactions support local structural distortions. Journal of molecular biology. 2002 Academic Article GET IT
Times cited: 17
Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers. 2002 Academic Article GET IT
Times cited: 80
Three-dimensional representations of G protein-coupled receptor structures and mechanisms. Methods in enzymology. 2002 Academic Article GET IT
Times cited: 172
Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. Biochemistry. 2001 Academic Article GET IT
Times cited: 79
Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. Biochemistry. 2001 Academic Article GET IT
Times cited: 66
Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors. Biochemistry. 2001 Academic Article GET IT
Times cited: 30
Differences in conformational properties of the second intracellular loop (IL2) in 5HT(2C) receptors modified by RNA editing can account for G protein coupling efficiency. Protein engineering. 2001 Academic Article GET IT
Times cited: 24
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nature genetics. 2001 Academic Article GET IT
Times cited: 470
Modeling multi-component protein-DNA complexes: the role of bending and dimerization in the complex of p53 dimers with DNA. Protein engineering. 2001 Academic Article GET IT
Times cited: 18
Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites. Biochemistry. 2000 Academic Article GET IT
Times cited: 36
A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specific binding. Journal of molecular biology. 2000 Academic Article GET IT
Times cited: 137
Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices. Trends in pharmacological sciences. 2000 Review GET IT
Times cited: 267
Molecular dynamics simulations predict a tilted orientation for the helical region of dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers. Biophysical journal. 2000 Academic Article GET IT
Times cited: 47
The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle. Biochemistry. 2000 Academic Article GET IT
Times cited: 63
Prokink: a protocol for numerical evaluation of helix distortions by proline. Protein engineering. 2000 Academic Article GET IT
Times cited: 92
Multiple interactions of the Asp(2.61(98)) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction. Biochemistry. 2000 Academic Article GET IT
Times cited: 63
Interactive construction of residue-based diagrams of proteins: the RbDe web service. Protein engineering. 2000 Academic Article GET IT
Times cited: 21
Binding mechanisms of TATA box-binding proteins: DNA kinking is stabilized by specific hydrogen bonds. Biophysical journal. 2000 Academic Article GET IT
Times cited: 19
The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 75
The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions. Biophysical journal. 1999 Academic Article GET IT
Times cited: 96
Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor. FEBS letters. 1999 Academic Article GET IT
Times cited: 47
Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis. The Journal of clinical investigation. 1999 Academic Article GET IT
Times cited: 141
TIT for TAT: the properties of inosine and adenosine in TATA box DNA. Journal of biomolecular structure & dynamics. 1999 Academic Article GET IT
Times cited: 20
Schematic representation of residue-based protein context-dependent data: an application to transmembrane proteins. Journal of molecular graphics & modelling. 1999 Academic Article GET IT
Times cited: 14
Selective binding of the TATA box-binding protein to the TATA box-containing promoter: analysis of structural and energetic factors. Biophysical journal. 1998 Academic Article GET IT
Times cited: 19
A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif. Biophysical journal. 1998 Academic Article GET IT
Times cited: 69
Progressive DNA bending is made possible by gradual changes in the torsion angle of the glycosyl bond. Biophysical journal. 1998 Academic Article GET IT
Times cited: 11
Functional microdomains in G-protein-coupled receptors. The conserved arginine-cage motif in the gonadotropin-releasing hormone receptor. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 235
Structure and dynamics of calmodulin in solution. Biophysical journal. 1998 Academic Article GET IT
Times cited: 132
Neurofilament (NF) assembly; divergent characteristics of human and rodent NF-L subunits. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 56
A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice. Biochemistry. 1998 Academic Article GET IT
Times cited: 163
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor. The EMBO journal. 1997 Academic Article GET IT
Times cited: 357
Comparative modeling and molecular dynamics studies of the delta, kappa and mu opioid receptors. Protein engineering. 1997 Academic Article GET IT
Times cited: 74
Does TATA matter? A structural exploration of the selectivity determinants in its complexes with TATA box-binding protein. Biophysical journal. 1997 Academic Article GET IT
Times cited: 38
Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor. Endocrine reviews. 1997 Review GET IT
Times cited: 442
A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 46
Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 266
Gbeta subunit interacts with a peptide encoding region 956-982 of adenylyl cyclase 2. Cross-linking of the peptide to free Gbetagamma but not the heterotrimer. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 47
Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice. Biochemistry. 1996 Academic Article GET IT
Times cited: 124
Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the same locus. Molecular pharmacology. 1996 Academic Article GET IT
Times cited: 75
Mapping the binding site pocket of the serotonin 5-Hydroxytryptamine2A receptor. Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of lysergic acid diethylamide or bufotenin. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 134
Structure and Activity of Membrane Receptors: Modeling and Computational Simulation of Ligand Recognition in a Three-Dimensional Model of the 5-Hydroxytryptamine(1A) Receptor. Journal of biomedical science. 1996 Academic Article GET IT
Structural change mechanisms in regulatory proteins. Science (New York, N.Y.). 1996 Letter GET IT
Times cited: 1
A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 99
Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 205
Functional role of arginine-11 in the N-terminal helix of skeletal troponin C: combined mutagenesis and molecular dynamics investigation. Biochemistry. 1995 Academic Article GET IT
Times cited: 11
Electrostatic analysis of DNA binding properties in lysine to leucine mutants of TATA-box binding proteins. Protein engineering. 1995 Academic Article GET IT
Times cited: 8
Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor. Protein engineering. 1994 Academic Article GET IT
Times cited: 61
A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Molecular pharmacology. 1994 Academic Article GET IT
Times cited: 273
Polarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsin. FEBS letters. 1994 Academic Article GET IT
Times cited: 47
Ca(2+)-binding and structural dynamics in the functions of calmodulin. Annual review of physiology. 1994 Review GET IT
Times cited: 111
Hallucinogens acting at 5-HT receptors: toward a mechanistic understanding at atomic resolution. NIDA research monograph. 1994 Review GET IT
Times cited: 2
Signal transduction by a 5-HT2 receptor: a mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands. Journal of medicinal chemistry. 1993 Academic Article GET IT
Times cited: 98
On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 1992 Academic Article GET IT
Times cited: 91
Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains. Biophysical journal. 1992 Academic Article GET IT
Times cited: 99
The role of Pro/Hyp-kinks in determining the transmembrane helix length and gating mechanism of a [Leu]zervamicin channel. Biophysical journal. 1992 Academic Article GET IT
Times cited: 13
Structural dynamics of calmodulin and troponin C. Protein engineering. 1991 Academic Article GET IT
Times cited: 39
A mechanistic basis for design of selective agonists for 5-HT receptors. NIDA research monograph. 1991 Review GET IT
Times cited: 1
Molecular mechanisms of radiation induced DNA damage: H-abstraction and beta-cleavage. Free radical research communications. 1991 Academic Article GET IT
Times cited: 4
Molecular mechanisms of radiation induced DNA damage: H-addition to bases, direct ionization and double strand break. Free radical research communications. 1991 Academic Article GET IT
Times cited: 6
Structure-function relations in radiation damaged DNA. Basic life sciences. 1991 Review GET IT
Times cited: 4
Theoretical analysis of the activity of dimaprit derivatives on the H2-receptor. Agents and actions. Supplements. 1991 Academic Article GET IT
Times cited: 7
On the structural and mechanistic basis of function, classification, and ligand design for 5-HT receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 1990 Review GET IT
Times cited: 21
On the ion selectivity in Ca-binding proteins: the cyclo(-L-Pro-Gly-)3 peptide as a model. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 37
A metactoid sensitization model to describe multiple receptors linked to a common response: application to histamine receptors coupled to [3H]cyclic AMP accumulation in guinea pig cortex. Molecular pharmacology. 1989 Academic Article GET IT
Times cited: 1
A molecular theoretical model of recognition and activation at a 5-HT receptor. Progress in clinical and biological research. 1989 Academic Article GET IT
Times cited: 3
Theoretical studies of molecular mechanisms of DNA damage induced by hydroxyl radicals. Free radical research communications. 1989 Academic Article GET IT
Times cited: 6
Structural and energetic parameters of Ca2+ binding to peptides and proteins. Biopolymers. 1988 Academic Article GET IT
Times cited: 22
Role of primary and secondary protein structure in neurotransmitter receptor activation mechanisms. Protein engineering. 1988 Review GET IT
Times cited: 7
Recognition and activation of a 5-HT receptor by hallucinogens and indole derivatives. NIDA research monograph. 1988 Review GET IT
Times cited: 3
A molecular model for activation of a 5-hydroxytryptamine receptor. Molecular pharmacology. 1987 Academic Article GET IT
Times cited: 27
Molecular determinants for recognition of triazole and tetrazole analogs of histamine at H2-receptors. Molecular pharmacology. 1987 Academic Article GET IT
Times cited: 13
Pharmacological characterization of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes. Molecular pharmacology. 1987 Academic Article GET IT
Times cited: 116
Analysis of the molecular electrostatic potential for the prediction of N-oxidation and biological activity of substituted pyridines. Molecular toxicology. 1987 Academic Article GET IT
Times cited: 5
Molecular determinants for the agonist activity of 2-methylhistamine and 4-methylhistamine at H2-receptors. Journal of medicinal chemistry. 1986 Academic Article GET IT
Times cited: 15
On the role of computational approaches to enzyme structure and function in the study of molecular processes in biology. An introduction. Enzyme. 1986 Academic Article GET IT
Times cited: 2
Theoretical studies on the activation mechanism of the histamine H2-receptor: the proton transfer between histamine and a receptor model. Molecular pharmacology. 1986 Academic Article GET IT
Times cited: 56
Determinants of molecular reactivity as criteria for predicting toxicity: problems and approaches. Environmental health perspectives. 1985 Review GET IT
Times cited: 15
Structural analysis of carboxypeptidase A and its complexes with inhibitors as a basis for modeling enzyme recognition and specificity. Biopolymers. 1985 Academic Article GET IT
Times cited: 46
Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone. European journal of pharmacology. 1985 Academic Article GET IT
Times cited: 94
A molecular theory of recognition and activation at a 5-HT receptor based on a quantum chemical approach to structure activity relationships. Clinical physiology and biochemistry. 1985 Academic Article GET IT
Times cited: 12
A theoretical investigation of histamine tautomerism. Journal of medicinal chemistry. 1984 Academic Article GET IT
Times cited: 55
Differences in d-[3H]lysergic acid diethylamide binding in mouse cortex and hippocampus in vivo and in vitro revealed by radioautography and rapid filtration studies. The Journal of pharmacology and experimental therapeutics. 1984 Academic Article GET IT
Times cited: 11
Discriminant effects of behaviorally active and inactive analogs of phencyclidine on membrane electrical excitability. The Journal of pharmacology and experimental therapeutics. 1984 Academic Article GET IT
Times cited: 4
Multiple actions of phencyclidine: discriminant structure-activity relationships from molecular conformations and assay conditions. Federation proceedings. 1983 Academic Article GET IT
Times cited: 5
Enhanced serotonin-stimulated adenylate cyclase activity in membranes from adult guinea pig hippocampus. Life sciences. 1983 Academic Article GET IT
Times cited: 28
Effects of phencyclidine on cardiac action potential: pH dependence and structure-activity relationships. European journal of pharmacology. 1983 Academic Article GET IT
Times cited: 12
Site of action of phencyclidine. IV. Interaction of phencyclidine and its analogues on ionic channels of the electrically excitable membrane and nicotinic receptor: implications for behavioral effects. Molecular pharmacology. 1982 Academic Article GET IT
Times cited: 15
Response of the histamine h2-receptor in brain to antidepressant drugs. Advances in biochemical psychopharmacology. 1982 Review GET IT
Times cited: 17
The behavioral effects of phencyclidines may be due to their blockade of potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 1981 Academic Article GET IT
Times cited: 64
Models for active sites of metalloenzymes. II. Interactions with a model substrate. Annals of the New York Academy of Sciences. 1981 Academic Article GET IT
Times cited: 13
Quantum chemical studies on molecular determinants for drug action. Annals of the New York Academy of Sciences. 1981 Academic Article GET IT
Times cited: 34
Phencyclidine (PCP) and derivatives: pharmacology and structure-activity relationships [proceedings]. Psychopharmacology bulletin. 1980 Academic Article GET IT
Times cited: 2
"Specific binding" of 3H-phencyclidine: artifacts of the rapid filtration method. Life sciences. 1980 Academic Article GET IT
Times cited: 31
Histamine and psychotropic drugs. Psychopharmacology bulletin. 1980 Academic Article GET IT
Times cited: 3
One agonist and two receptors mediating the same effect: histamine receptors linked to adenylate cyclase in the brain. Advances in biochemical psychopharmacology. 1980 Academic Article GET IT
Times cited: 12
Psychiatry on trial: clinical and ethical problems in the psychiatric assessment of competency to stand trial. Annals of the New York Academy of Sciences. 1980 Academic Article GET IT
[13C]NMR chemical shifts and calculated electronic structures of serotonin congeners: relation to biological activity. Molecular pharmacology. 1979 Academic Article GET IT
Times cited: 2
Studies on histamine H2 receptors coupled to cardiac adenylate cyclase. Effects of guanylnucleotides and structural requirements for agonist activity. Biochimica et biophysica acta. 1979 Academic Article GET IT
Times cited: 23
Studies on histamine H2 receptors coupled to cardiac adenylate cyclase. Blockade by H2 and H1 receptor antagonists. Molecular pharmacology. 1979 Academic Article GET IT
Times cited: 26
An improved correction of distorted indicator-dilution curves. IEEE transactions on bio-medical engineering. 1979 Academic Article GET IT
Some structure activity relationships of phencyclidine derivatives as anticholinergic agents in vitro and in vivo. Progress in clinical and biological research. 1979 Academic Article GET IT
Times cited: 9
Evaluation of congenital heart defects from dynamic tracer measurements. 1978 GET IT
Times cited: 1
Defining the histamine H2-receptor in brain: the interaction with LSD. NIDA research monograph. 1978 Review GET IT
Times cited: 8
Recognition and activation mechanisms on the LSD/serotonin receptor: the molecular basis of structure activity relationships. NIDA research monograph. 1978 Academic Article GET IT
Times cited: 7
Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide. Proceedings of the National Academy of Sciences of the United States of America. 1977 Academic Article GET IT
Times cited: 90
A theoretical model study of the comparative effectiveness of atropine and scopolamine action in the central nervous system. Journal of theoretical biology. 1977 Academic Article GET IT
Times cited: 7
Tautomerism and the receptor action of histamine: a mechanistic model. Molecular pharmacology. 1976 Academic Article GET IT
Times cited: 105
A theoretical and experimental study of the semirigid cholinergic agonist 3-acetoxyquinuclidine. Molecular pharmacology. 1975 Academic Article GET IT
Times cited: 24
Psychotomimetics as anticholinergic agents. I. 1-Cyclohexylpiperidine derivatives: anticholinesterase activity and antagonistic activity to acetylcholine. Biochemical pharmacology. 1974 Academic Article GET IT
Times cited: 119
Cholinolytic action of phencyclidine derivatives. European journal of pharmacology. 1974 Academic Article GET IT
Times cited: 27
Acetylcholine-like molecular arrangement in psychomimetic anticholinergic drugs. Proceedings of the National Academy of Sciences of the United States of America. 1973 Academic Article GET IT
Times cited: 36
Psychotomimetic drugs as anticholinergic agents. II. Quantum-mechanical study of molecular interaction potentials of 1-cyclohexylpiperidine derivatives with the cholinergic receptor. Molecular pharmacology. 1973 Academic Article GET IT
Times cited: 63
The treatment of acute pulmonary edema with furosemide. Current therapeutic research, clinical and experimental. 1966 Academic Article GET IT
Times cited: 6

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Research

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Funding awarded

SUPPLEMENT - BIGDATA: IA: Collaborative Research: In Situ Data Analytics for Next Generation Molecular Dynamics Workflows awarded by National Science Foundation Principal Investigator 2021 - 2023
BIGDATA: IA: Collaborative Research: In Situ Data Analytics for Next Generation Molecular Dynamics Workflows awarded by National Science Foundation Principal Investigator 2017 - 2023

Ca2+-dependent lipid scrambling and ion transport by TMEM16 proteins awarded by National Institute of General Medical Sciences Key Personnel 2019 - 2024

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Background

education and training

D.Sc., Technion-Israel Institute of Technology (Israel) 1971
M.Sc., Technion-Israel Institute of Technology (Israel) 1968
Bs.C., Technion-Israel Institute of Technology (Israel) 1966

Contact

full name

Harel Weinstein

primary email

haw2002@med.cornell.edu

VIVO Weill Cornell Medical College

Harel Weinstein Professor of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email