Tilgner, Hagen

Publications

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selected publications

A guide to the BRAIN Initiative Cell Census Network data ecosystem. PLoS biology. 2023 Academic Article GET IT
Times cited: 418
From words to complete phrases: insight into single-cell isoforms using short and long reads. Transcription. 2023 Review GET IT
Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development. bioRxiv : the preprint server for biology. 2023 Article GET IT
Times cited: 13
Accurate isoform discovery with IsoQuant using long reads. Nature biotechnology. 2023 Academic Article GET IT
Times cited: 13838
The variables on RNA molecules: concert or cacophony? Answers in long-read sequencing. Nature methods. 2023 Academic Article GET IT
Times cited: 1
ScisorWiz: visualizing differential isoform expression in single-cell long-read data. Bioinformatics (Oxford, England). 2022 Academic Article GET IT
Times cited: 3
Sequencing of individual barcoded cDNAs using Pacific Biosciences and Oxford Nanopore Technologies reveals platform-specific error patterns. Genome research. 2022 Academic Article GET IT
Times cited: 6
Induction of an immortalized songbird cell line allows for gene characterization and knockout by CRISPR-Cas9. Scientific reports. 2022 Academic Article GET IT
Times cited: 5
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue. Nature biotechnology. 2022 Academic Article GET IT
Times cited: 15
Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids. Molecular psychiatry. 2021 Academic Article GET IT
Times cited: 27
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain. Nature communications. 2021 Academic Article GET IT
Times cited: 54
Getting the Entire Message: Progress in Isoform Sequencing. Frontiers in genetics. 2019 Review GET IT
Times cited: 2406
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 2019 Academic Article GET IT
Times cited: 253
The tech for the next decade: promises and challenges in genome biology. Genome biology. 2019 Conference Paper GET IT
Times cited: 2
Targeted, High-Resolution RNA Sequencing of Non-coding Genomic Regions Associated With Neuropsychiatric Functions. Frontiers in genetics. 2019 Academic Article GET IT
Times cited: 289
Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells. Nature biotechnology. 2018 Academic Article GET IT
Times cited: 147
Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework. Genome medicine. 2017 Review GET IT
Times cited: 42
Microfluidic isoform sequencing shows widespread splicing coordination in the human transcriptome. Genome research. 2017 Academic Article GET IT
Times cited: 38
Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis. Nature communications. 2017 Academic Article GET IT
Times cited: 159
Erratum to: Promoter-like epigenetic signatures in exons displaying cell type-specific splicing. Genome biology. 2016 Article GET IT
Times cited: 19
Promoter-like epigenetic signatures in exons displaying cell type-specific splicing. Genome biology. 2015 Academic Article GET IT
Times cited: 20
Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans. Genome research. 2015 Academic Article GET IT
Times cited: 122
Absence of canonical marks of active chromatin in developmentally regulated genes. Nature genetics. 2015 Academic Article GET IT
Times cited: 55
Comprehensive transcriptome analysis using synthetic long-read sequencing reveals molecular co-association of distant splicing events. Nature biotechnology. 2015 Academic Article GET IT
Times cited: 132
Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing. RNA (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 14
Defining a personal, allele-specific, and single-molecule long-read transcriptome. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 170
A single-molecule long-read survey of the human transcriptome. Nature biotechnology. 2013 Academic Article GET IT
Times cited: 420
Accurate identification and analysis of human mRNA isoforms using deep long read sequencing. G3 (Bethesda, Md.). 2013 Academic Article GET IT
Times cited: 46
An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 Academic Article GET IT
Times cited: 11446
Landscape of transcription in human cells. Nature. 2012 Academic Article GET IT
Times cited: 3742
Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs. Genome research. 2012 Academic Article GET IT
Times cited: 317
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome research. 2012 Academic Article GET IT
Times cited: 3759
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS biology. 2011 Academic Article GET IT
Times cited: 76
A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS biology. 2011 Academic Article GET IT
Times cited: 902
From chromatin to splicing: RNA-processing as a total artwork. Epigenetics. 2010 Academic Article GET IT
Times cited: 22
Nucleosome positioning as a determinant of exon recognition. Nature structural & molecular biology. 2009 Academic Article GET IT
Times cited: 348

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Research

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Funding awarded

Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV awarded by National Institute on Drug Abuse Principal Investigator 2022 - 2026
Integrative Single Cell Isoform And Chromatin Accessibility Mapping Of Chronic Opioid Exposure In Cognitive Brain Areas In HIV awarded by National Institute on Drug Abuse Principal Investigator 2021 - 2026
Cross-species conservation of cell-type and single-cell specific isoform expression awarded by National Institute of General Medical Sciences Principal Investigator 2021 - 2024
Cross-species conservation of cell-type and single-cell specific isoform expression awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2024
Single cell isoform expression across mouse brain regions and development awarded by National Institute of Mental Health Principal Investigator 2019 - 2023

Center for Lupus Research awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator 2022 - 2027
Contribution of G Protein Coupled Estrogen Receptor to Changes in Hypothalamic Plasticity and Hypertension Susceptibility in Mice with Accelerated Ovarian Failure awarded by National Heart, Lung, & Blood Institute Co-Investigator 2023 - 2026
Clinical and Molecular Heterogeneity in the Myelodysplastic Syndromes awarded by National Cancer Institute Co-Investigator 2020 - 2025

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Background

education and training

Ph.D., Pompeu Fabra University (Spain) 2011
M.Sc., University of Karlsruhe (Germany) 2005
M.Sc., Joseph Fourier University (Grenoble I) Faculty of Medicine (France) 2005

Contact

full name

Hagen Tilgner

primary email

hut2006@med.cornell.edu

VIVO Weill Cornell Medical College

Hagen Tilgner Associate Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email