Burre, Jacqueline

Publications

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selected publications

α-Synuclein in synaptic function and dysfunction. Trends in neurosciences. 2022 Review GET IT
Times cited: 6
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models. Nature communications. 2022 Academic Article GET IT
Times cited: 8
Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes. Journal of molecular biology. 2022 Review GET IT
Times cited: 7
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. Cell reports. 2022 Academic Article GET IT
Times cited: 14
Targeted stabilization of Munc18-1 function via pharmacological chaperones. EMBO molecular medicine. 2020 Academic Article GET IT
Times cited: 3
STXBP1 encephalopathies: Clinical spectrum, disease mechanisms, and therapeutic strategies. Journal of neurochemistry. 2020 Review GET IT
Times cited: 36
Aggregation of mutant cysteine string protein-α via Fe-S cluster binding is mitigated by iron chelators. Nature structural & molecular biology. 2020 Academic Article GET IT
Times cited: 7
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones. Nature communications. 2018 Academic Article GET IT
Times cited: 37
Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harbor perspectives in medicine. 2018 Review GET IT
Times cited: 262
Modulating membrane binding of α-synuclein as a therapeutic strategy. Proceedings of the National Academy of Sciences of the United States of America. 2017 Comment GET IT
Times cited: 36
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. PLoS biology. 2015 Academic Article GET IT
Times cited: 56
Definition of a molecular pathway mediating α-synuclein neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 142
The Synaptic Function of α-Synuclein. Journal of Parkinson's disease. 2015 Review GET IT
Times cited: 323
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 319
Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity. Neuron. 2014 Academic Article GET IT
Times cited: 45
Properties of native brain α-synuclein. Nature. 2013 Comment GET IT
Times cited: 241
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2. eLife. 2013 Academic Article GET IT
Times cited: 234
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 125
Proteasome inhibition alleviates SNARE-dependent neurodegeneration. Science translational medicine. 2012 Academic Article GET IT
Times cited: 56
CSPα knockout causes neurodegeneration by impairing SNAP-25 function. The EMBO journal. 2011 Academic Article GET IT
Times cited: 112
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nature cell biology. 2010 Academic Article GET IT
Times cited: 184
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 1251
Non-classical 2-D electrophoresis. Methods in molecular biology (Clifton, N.J.). 2009 Academic Article GET IT
Times cited: 15
Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter. Journal of neurochemistry. 2007 Academic Article GET IT
Times cited: 28
The synaptic vesicle proteome. Journal of neurochemistry. 2007 Review GET IT
Times cited: 80
Immunoisolation and subfractionation of synaptic vesicle proteins. Analytical biochemistry. 2007 Academic Article GET IT
Times cited: 16
Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques. Proteomics. 2006 Academic Article GET IT
Times cited: 84
Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis. Electrophoresis. 2006 Academic Article GET IT
Times cited: 32
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis. Journal of neurochemistry. 2005 Academic Article GET IT
Times cited: 129

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Research

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Funding awarded

The impact of beta- and gamma-synucleins on alpha-synuclein''s synaptic function awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2025
The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathology awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2020 - 2025
Synaptic vesicle changes in synucleinopathies awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2024
Molecular Mechanisms of Munc18-1 Linked Infantile Seizure Disorders and Rational Rescue Strategies awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2017 - 2024
Rescue of STXBP1 encephalopathies with small molecules in mouse models in vivo awarded by Orphan Disease Center at University of Pennsylvania Principal Investigator 2022 - 2023
Changes in synaptic vesicle-binding of alpha-synuclein in the central and enteric nervous system awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2023
Addgene 699480 awarded by Addgene, Inc. Principal Investigator 2022 - 2023

Clinical and Translational Science Center - UL1 awarded by National Center for Advancing Translational Sciences Co-Investigator 2022 - 2027

The role of beta-synuclein in synaptic vesicle release awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2022 - 2025
Munc18-1 mutations disrupt syntaxin-5 stability and general secretory trafficking awarded by National Institute of Child Health & Human Development Key Personnel 2020 - 2024
Rescue of STXBP1 encephalopathies with 4-phenylbutyrate in a mouse model awarded by American Epilepsy Society Key Personnel 2022 - 2023

The role of VAMP2 in alpha-synuclein function and pathology awarded by National Institute of Neurological Disorders & Stroke Principal Investigator Subaward 2021 - 2026

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Background

education and training

Ph.D., Johann Wolfgang Goethe University (Germany) 2006
Diploma, Johann Wolfgang Goethe University (Germany) 2003

Contact

full name

Jacqueline Burre

primary email

jab2058@med.cornell.edu

VIVO Weill Cornell Medical College

Jacqueline Burre Associate Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email