Krumsiek, Jan

Publications

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selected publications

A multimodal atlas of tumour metabolism reveals the architecture of gene-metabolite covariation. Nature metabolism. 2023 Review GET IT
Interplay of Metabolome and Gut Microbiome in Individuals With Major Depressive Disorder vs Control Individuals. JAMA psychiatry. 2023 Academic Article GET IT
Times cited: 1
piTracer - Automatic reconstruction of molecular cascades for the identification of synergistic drug targets. bioRxiv : the preprint server for biology. 2023 Article GET IT
Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism. bioRxiv : the preprint server for biology. 2023 Article GET IT
Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS. Molecular medicine (Cambridge, Mass.). 2023 Academic Article GET IT
Times cited: 1
rox: A Statistical Model for Regression with Missing Values. Metabolites. 2023 Academic Article GET IT
Times cited: 35
Microbes Contribute to Chemopreventive Efficacy, Intestinal Tumorigenesis, and the Metabolome. Cancer prevention research (Philadelphia, Pa.). 2022 Academic Article GET IT
Improved Macro- and Micronutrient Supply for Favorable Growth and Metabolomic Profile with Standardized Parenteral Nutrition Solutions for Very Preterm Infants. Nutrients. 2022 Academic Article GET IT
Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS. PLoS pathogens. 2022 Academic Article GET IT
Times cited: 6
Authors' Reply. The American journal of pathology. 2022 Letter GET IT
Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS. medRxiv : the preprint server for health sciences. 2022 Article GET IT
Times cited: 1081
Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS. medRxiv : the preprint server for health sciences. 2022 Article GET IT
Times cited: 11
The landscape of metabolic brain alterations in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Academic Article GET IT
Times cited: 4
Variational autoencoders learn transferrable representations of metabolomics data. Communications biology. 2022 Academic Article GET IT
Times cited: 3
Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma. Science advances. 2022 Academic Article GET IT
Times cited: 1
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19. iScience. 2022 Academic Article GET IT
Times cited: 17082
Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia. Pediatric research. 2022 Academic Article GET IT
Times cited: 2
Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome. The American journal of pathology. 2022 Academic Article GET IT
Times cited: 11
Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology. Nature communications. 2022 Academic Article GET IT
Times cited: 13
maplet: an extensible R toolbox for modular and reproducible metabolomics pipelines. Bioinformatics (Oxford, England). 2022 Academic Article GET IT
Times cited: 8
Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies. Frontiers in immunology. 2022 Academic Article GET IT
Times cited: 10
Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment. Frontiers in immunology. 2022 Academic Article GET IT
Times cited: 9
SGI: automatic clinical subgroup identification in omics datasets. Bioinformatics (Oxford, England). 2022 Academic Article GET IT
Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 Academic Article GET IT
Times cited: 21
The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases. Science advances. 2021 Academic Article GET IT
Times cited: 10
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice. Nature metabolism. 2021 Academic Article GET IT
Times cited: 24
Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis. Thorax. 2021 Academic Article GET IT
Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas. Cancer research. 2021 Academic Article GET IT
Times cited: 8
A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression. Molecular psychiatry. 2021 Academic Article GET IT
Times cited: 13
Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study. Genetic epidemiology. 2021 Academic Article GET IT
Times cited: 2
The Colorectal Cancer Lipidome: Identification of a Robust Tumor-Specific Lipid Species Signature. Gastroenterology. 2021 Academic Article GET IT
Times cited: 29
Seasonal Regulation of Metabolism: The Effect of Wintertime Fasting and Autumnal Fattening on Key Central Regulators of Metabolism and the Metabolic Profile of the Raccoon Dog (Nyctereutes Procyonoides). International journal of molecular sciences. 2021 Academic Article GET IT
Times cited: 1
A Panel of 6 Biomarkers Significantly Improves the Prediction of Type 2 Diabetes in the MONICA/KORA Study Population. The Journal of clinical endocrinology and metabolism. 2021 Academic Article GET IT
Times cited: 7
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil. Cancer research. 2021 Academic Article GET IT
Times cited: 40
A Workflow for Missing Values Imputation of Untargeted Metabolomics Data. Metabolites. 2020 Academic Article GET IT
Times cited: 2563
Multi-omics integration in biomedical research - A metabolomics-centric review. Analytica chimica acta. 2020 Review GET IT
Times cited: 72
A strategy to incorporate prior knowledge into correlation network cutoff selection. Nature communications. 2020 Academic Article GET IT
Times cited: 9
Systematic Evaluation of Normalization Methods for Glycomics Data Based on Performance of Network Inference. Metabolites. 2020 Academic Article GET IT
Times cited: 6
Proteome-wide assessment of diabetes mellitus in Qatari identifies IGFBP-2 as a risk factor already with early glycaemic disturbances. Archives of biochemistry and biophysics. 2020 Academic Article GET IT
Times cited: 4
Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome. Nature communications. 2020 Academic Article GET IT
Times cited: 64
Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population. Scientific reports. 2020 Academic Article GET IT
Times cited: 8
Correction to: A network-based conditional genetic association analysis of the human metabolome. GigaScience. 2019 Academic Article GET IT
A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study. Scientific reports. 2019 Academic Article GET IT
Times cited: 10
Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS). Metabolites. 2019 Academic Article GET IT
Times cited: 156
Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective. Metabolites. 2019 Review GET IT
Times cited: 32
Characterization of Bulk Phosphatidylcholine Compositions in Human Plasma Using Side-Chain Resolving Lipidomics. Metabolites. 2019 Academic Article GET IT
Times cited: 29
Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants. PloS one. 2019 Academic Article GET IT
Common patterns of gene regulation associated with Cesarean section and the development of islet autoimmunity - indications of immune cell activation. Scientific reports. 2019 Academic Article GET IT
Times cited: 5
A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease. Journal of proteome research. 2019 Academic Article GET IT
Times cited: 12
MoDentify: phenotype-driven module identification in metabolomics networks at different resolutions. Bioinformatics (Oxford, England). 2019 Academic Article GET IT
Times cited: 11
Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans. American journal of physiology. Endocrinology and metabolism. 2019 Academic Article GET IT
Times cited: 74
A network-based conditional genetic association analysis of the human metabolome. GigaScience. 2018 Academic Article GET IT
Times cited: 9
Comparison of metabolite networks from four German population-based studies. International journal of epidemiology. 2018 Academic Article GET IT
Times cited: 8
Hepatic Steatosis Is Associated With Adverse Molecular Signatures in Subjects Without Diabetes. The Journal of clinical endocrinology and metabolism. 2018 Academic Article GET IT
Times cited: 19
Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies. Metabolomics : Official journal of the Metabolomic Society. 2018 Academic Article GET IT
Times cited: 94
The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice. Nature communications. 2018 Academic Article GET IT
Times cited: 147
A Systemic Inflammatory Signature Reflecting Cross Talk Between Innate and Adaptive Immunity Is Associated With Incident Polyneuropathy: KORA F4/FF4 Study. Diabetes. 2018 Academic Article GET IT
Times cited: 31
Dilution correction for dynamically influenced urinary analyte data. Analytica chimica acta. 2018 Academic Article GET IT
Times cited: 9
Associations of maternal type 1 diabetes with childhood adiposity and metabolic health in the offspring: a prospective cohort study. Diabetologia. 2018 Academic Article GET IT
Times cited: 16
Comprehensive Metabolic Profiling Reveals a Lipid-Rich Fingerprint of Free Thyroxine Far Beyond Classic Parameters. The Journal of clinical endocrinology and metabolism. 2018 Academic Article GET IT
Times cited: 9
Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children. PLoS medicine. 2018 Academic Article GET IT
Times cited: 76
Eating less or more - Mindset induced changes in neural correlates of pre-meal planning. Appetite. 2018 Academic Article GET IT
Times cited: 27
Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns. Frontiers in immunology. 2018 Academic Article GET IT
Times cited: 37
Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway. Nature communications. 2018 Academic Article GET IT
Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway. EBioMedicine. 2018 Academic Article GET IT
Times cited: 20
Allele-specific methylation of type 1 diabetes susceptibility genes. Journal of autoimmunity. 2017 Academic Article GET IT
Times cited: 23
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway. Nature communications. 2017 Academic Article GET IT
Times cited: 35
Phenotype-driven identification of modules in a hierarchical map of multifluid metabolic correlations. NPJ systems biology and applications. 2017 Academic Article GET IT
Times cited: 50
Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young. Pediatric diabetes. 2017 Academic Article GET IT
Times cited: 15
N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes. Cell metabolism. 2017 Academic Article GET IT
Times cited: 65
Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Academic Article GET IT
Times cited: 14
Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model. Scientific reports. 2016 Academic Article GET IT
Times cited: 39
Peptide serum markers in islet autoantibody-positive children. Diabetologia. 2016 Academic Article GET IT
Times cited: 13
Metabolic Fingerprints of Circulating IGF-1 and the IGF-1/IGFBP-3 Ratio: A Multifluid Metabolomics Study. The Journal of clinical endocrinology and metabolism. 2016 Academic Article GET IT
Times cited: 17
Lactation is associated with altered metabolomic signatures in women with gestational diabetes. Diabetologia. 2016 Academic Article GET IT
Times cited: 20
Software tools for single-cell tracking and quantification of cellular and molecular properties. Nature biotechnology. 2016 Letter GET IT
Times cited: 120
Computational approaches for systems metabolomics. Current opinion in biotechnology. 2016 Review GET IT
Times cited: 41
Metabolomics reveals effects of maternal smoking on endogenous metabolites from lipid metabolism in cord blood of newborns. Metabolomics : Official journal of the Metabolomic Society. 2016 Academic Article GET IT
Unbiased Prediction and Feature Selection in High-Dimensional Survival Regression. Journal of computational biology : a journal of computational molecular cell biology. 2016 Academic Article GET IT
Times cited: 17
Alterations in Lipid and Inositol Metabolisms in Two Dopaminergic Disorders. PloS one. 2016 Academic Article GET IT
Times cited: 24
Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema. Clinical science (London, England : 1979). 2015 Academic Article GET IT
Times cited: 29
A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population. Journal of the American Society of Nephrology : JASN. 2015 Academic Article GET IT
Times cited: 138
Erratum to: A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control. Diabetologia. 2015 Article GET IT
Gender-specific pathway differences in the human serum metabolome. Metabolomics : Official journal of the Metabolomic Society. 2015 Academic Article GET IT
Times cited: 239
The Human Blood Metabolome-Transcriptome Interface. PLoS genetics. 2015 Academic Article GET IT
Times cited: 71
A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control. Diabetologia. 2015 Academic Article GET IT
Times cited: 64
Multi-omic signature of body weight change: results from a population-based cohort study. BMC medicine. 2015 Academic Article GET IT
Times cited: 50
Erratum to: Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes. Diabetologia. 2015 Article GET IT
Network-based approach for analyzing intra- and interfluid metabolite associations in human blood, urine, and saliva. Journal of proteome research. 2014 Academic Article GET IT
Times cited: 34
Methods for sample acquisition and processing of serial blood and tumor biopsies for multicenter diffuse large B-cell lymphoma clinical trials. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2014 Editorial Article GET IT
Times cited: 4
Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes. Diabetologia. 2014 Academic Article GET IT
Times cited: 94
Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses. Human molecular genetics. 2014 Academic Article GET IT
Times cited: 24
An atlas of genetic influences on human blood metabolites. Nature genetics. 2014 Academic Article GET IT
Times cited: 737
Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study. International journal of obesity (2005). 2014 Academic Article GET IT
Times cited: 76
A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion. Acta diabetologica. 2013 Academic Article GET IT
Times cited: 19
Metabolite profiling reveals new insights into the regulation of serum urate in humans. Metabolomics : Official journal of the Metabolomic Society. 2013 Academic Article GET IT
Times cited: 263
Statistical methods for the analysis of high-throughput metabolomics data. Computational and structural biotechnology journal. 2013 Review GET IT
Times cited: 177
A study of Caenorhabditis elegans DAF-2 mutants by metabolomics and differential correlation networks. Molecular bioSystems. 2013 Academic Article GET IT
Times cited: 34
Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma. Allergy. 2013 Academic Article GET IT
Times cited: 64
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature genetics. 2012 Review GET IT
Times cited: 565
Metabolomic profiles in individuals with negative affectivity and social inhibition: a population-based study of Type D personality. Psychoneuroendocrinology. 2012 Academic Article GET IT
Times cited: 29
Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information. PLoS genetics. 2012 Academic Article GET IT
Times cited: 134
A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes. Genes and immunity. 2012 Academic Article GET IT
Times cited: 53
Identification and quantification of 1-hydroxybutene-2-yl mercapturic acid in human urine by UPLC- HILIC-MS/MS as a novel biomarker for 1,3-butadiene exposure. Chemical research in toxicology. 2012 Academic Article GET IT
Times cited: 14
Bayesian independent component analysis recovers pathway signatures from blood metabolomics data. Journal of proteome research. 2012 Academic Article GET IT
Times cited: 23
Body fat free mass is associated with the serum metabolite profile in a population-based study. PloS one. 2012 Academic Article GET IT
Times cited: 89
On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies. BMC bioinformatics. 2012 Academic Article GET IT
Times cited: 78
The dynamic range of the human metabolome revealed by challenges. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 Academic Article GET IT
Times cited: 251
Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS genetics. 2011 Academic Article GET IT
Times cited: 273
Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network. PloS one. 2011 Academic Article GET IT
Times cited: 110
Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data. BMC systems biology. 2011 Academic Article GET IT
Times cited: 217
Odefy--from discrete to continuous models. BMC bioinformatics. 2010 Academic Article GET IT
Times cited: 87
Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects. BMC genomics. 2010 Academic Article GET IT
Times cited: 114
Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling. BMC systems biology. 2009 Academic Article GET IT
Times cited: 161
Bootstrapping the interactome: unsupervised identification of protein complexes in yeast. Journal of computational biology : a journal of computational molecular cell biology. 2009 Academic Article GET IT
Times cited: 64
ProCope--protein complex prediction and evaluation. Bioinformatics (Oxford, England). 2008 Academic Article GET IT
Times cited: 31
SIMAP--structuring the network of protein similarities. Nucleic acids research. 2007 Academic Article GET IT
Times cited: 25
Gepard: a rapid and sensitive tool for creating dotplots on genome scale. Bioinformatics (Oxford, England). 2007 Academic Article GET IT
Times cited: 465

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Research

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Funding awarded

TargetAD: A systems multi-omics approach to drug repositioning in Alzheimer''s disease awarded by National Institute on Aging Principal Investigator 2021 - 2026
Rational design of drug combinations to target chemotherapy resistance in high-grade serous ovarian cancer via metabolomic profiling of patient-derived organoids awarded by National Cancer Institute Principal Investigator 2021 - 2024

Therapeutic Targeting of SIRT3 for Aggressive and Refractory Lymphomas awarded by National Cancer Institute Co-Investigator 2023 - 2028
Computational Drug Repurposing for AD/ADRD with Integrative Analysis of Real World Data and Biomedical Knowledge awarded by National Institute on Aging Co-Investigator 2022 - 2027
Metabolic and Inflammatory Response to a Whole Food Plant-Based Diet in Overweight/Obese Men with Prostate Cancer Receiving Androgen Deprivation Therapy: A Phase II Randomized Study awarded by Prostate Cancer Foundation Co-Investigator 2022 - 2024

Cancer Metabolism: Target and Predictor of Therapeutic Intervention in Breast cancer awarded by Qatar National Research Fund Principal Investigator Subaward 2020 - 2023
The Alzheimer''s Gut Microbiome Project awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2019 - 2023

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Background

education and training

Ph.D., Technical University of Munich (Germany) 2012
M.Sc., Technical University of Munich (Germany) 2009

Contact

full name

Jan Krumsiek

primary email

jak2043@med.cornell.edu

VIVO Weill Cornell Medical College

Jan Krumsiek Assistant Professor of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email