Lo, James C.

Publications

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selected publications

Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature. 2023 Academic Article GET IT
Times cited: 1
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nature cell biology. 2023 Academic Article GET IT
Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury. bioRxiv : the preprint server for biology. 2023 Article GET IT
Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure. Nature communications. 2022 Article GET IT
Times cited: 1
Pancreatic Islets as a Target of Adipokines. Comprehensive Physiology. 2022 Academic Article GET IT
Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure. Nature communications. 2022 Academic Article GET IT
Times cited: 4
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell metabolism. 2021 Article GET IT
Times cited: 11
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2. Cell metabolism. 2021 Academic Article GET IT
Times cited: 86
Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. eLife. 2021 Academic Article GET IT
Times cited: 19
Hyperglycemia in Acute COVID-19 is Characterized by Adipose Tissue Dysfunction and Insulin Resistance. medRxiv : the preprint server for health sciences. 2021 Article GET IT
Is IL-1 the Bridge Connecting Type 2 Diabetes and Cardiac Arrhythmias?. JACC. Basic to translational science. 2021 Editorial Article GET IT
Times cited: 1
Adipokines as key players in β cell function and failure. Clinical science (London, England : 1979). 2019 Review GET IT
Times cited: 8
Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nature medicine. 2019 Academic Article GET IT
Times cited: 76
Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions. Frontiers in physiology. 2018 Review GET IT
Times cited: 30
Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 39
Dnmt3a is an epigenetic mediator of adipose insulin resistance. eLife. 2017 Academic Article GET IT
Times cited: 75
Genetic Manipulation with Viral Vectors to Assess Metabolism and Adipose Tissue Function. Methods in molecular biology (Clifton, N.J.). 2017 Academic Article GET IT
Times cited: 7
A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell metabolism. 2016 Academic Article GET IT
Times cited: 101
Adipsin is an adipokine that improves β cell function in diabetes. Cell. 2014 Academic Article GET IT
Times cited: 244
IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 2014 Academic Article GET IT
Times cited: 192
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 2014 Academic Article GET IT
Times cited: 626
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Academic Article GET IT
Times cited: 636
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell metabolism. 2012 Academic Article GET IT
Times cited: 305
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Academic Article GET IT
Times cited: 3237
Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes & development. 2011 Academic Article GET IT
Times cited: 84
Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science (New York, N.Y.). 2007 Academic Article GET IT
Times cited: 121
NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. The Journal of clinical investigation. 2006 Academic Article GET IT
Times cited: 108
Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood. 2005 Academic Article GET IT
Times cited: 87
The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 155
Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. The Journal of clinical investigation. 2004 Academic Article GET IT
Times cited: 150
Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. The Journal of clinical investigation. 2003 Academic Article GET IT
Times cited: 83
Lymphotoxin pathway directs thymic Aire expression. Nature immunology. 2003 Academic Article GET IT
Times cited: 179
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. The Journal of clinical investigation. 2001 Academic Article GET IT
Times cited: 219
The critical role of LIGHT, a TNF family member, in T cell development. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 72
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications. The Journal of experimental medicine. 1999 Academic Article GET IT
Times cited: 88

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Research

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Funding awarded

Assessing the Impact of SARS-CoV-2 on Adipose Tissue Function and Glucose Homeostasis awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2023 - 2028
Mechanism of obesity-induced atrial fibrillation and boosting brown fat as a therapy (LIMA, RENAN) awarded by American Heart Association Principal Investigator 2023 - 2025
Dissecting the Cellular and Molecular Links Between Atrial Fibrillation and Obesity awarded by American Heart Association Principal Investigator 2022 - 2025
An Obesity-Induced Kinase that Regulates Adipose Homeostasis and Metabolic Diseases awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2019 - 2024
Addgene 698898 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Alternative complement pathway regulation of beta cell homeostasis awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2020 - 2023
Alternative complement pathway regulation of beta cell homeostasis awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2020 - 2023

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Background

education and training

M.D., University of Chicago Pritzker School of Medicine 2006
Ph.D., University of Chicago 2004
B.S., University of Chicago 1998

Contact

full name

James C. Lo

primary email

jal2063@med.cornell.edu

VIVO Weill Cornell Medical College

James C. Lo Associate Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email