Mezey, Jason

Publications

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selected publications

Cell-specific expression of lung disease risk-related genes in the human small airway epithelium. Respiratory research. 2020 Academic Article GET IT
Times cited: 16
Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium. American journal of respiratory and critical care medicine. 2020 Academic Article GET IT
Times cited: 157
Identifying novel associations in GWAS by hierarchical Bayesian latent variable detection of differentially misclassified phenotypes. BMC bioinformatics. 2020 Academic Article GET IT
Times cited: 3
Point of Care Exome Sequencing Reveals Allelic and Phenotypic Heterogeneity Underlying Mendelian disease in Qatar. Human molecular genetics. 2019 Academic Article GET IT
Times cited: 4
Role of KRAS in regulating normal human airway basal cell differentiation. Respiratory research. 2019 Academic Article GET IT
Times cited: 2
Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes. The European respiratory journal. 2019 Academic Article GET IT
Times cited: 22
Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome. American journal of respiratory and critical care medicine. 2018 Academic Article GET IT
Times cited: 13
Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia. Annals of neurology. 2018 Academic Article GET IT
Times cited: 13
Ontogeny and Biology of Human Small Airway Epithelial Club Cells. American journal of respiratory and critical care medicine. 2018 Academic Article GET IT
Times cited: 60
Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts. Epigenomics. 2018 Academic Article GET IT
Times cited: 3
Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population. PloS one. 2018 Academic Article GET IT
Times cited: 4
Inferring Identical-by-Descent Sharing of Sample Ancestors Promotes High-Resolution Relative Detection. American journal of human genetics. 2018 Academic Article GET IT
Times cited: 19
Point-of-care whole-exome sequencing of idiopathic male infertility. Genetics in medicine : official journal of the American College of Medical Genetics. 2018 Academic Article GET IT
Times cited: 41
Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration. Oncotarget. 2018 Academic Article GET IT
Times cited: 7
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population. Nature communications. 2018 Academic Article GET IT
Times cited: 41
XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris). PloS one. 2017 Academic Article GET IT
Times cited: 13
Benchmarking Relatedness Inference Methods with Genome-Wide Data from Thousands of Relatives. Genetics. 2017 Academic Article GET IT
Times cited: 45
An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci. PLoS computational biology. 2017 Academic Article GET IT
Times cited: 7
Waterpipe smoking induces epigenetic changes in the small airway epithelium. PloS one. 2017 Academic Article GET IT
Times cited: 26
Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder. PloS one. 2017 Academic Article GET IT
Times cited: 23
Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers. American journal of respiratory and critical care medicine. 2016 Academic Article GET IT
Times cited: 21
Correction: Type 2 Diabetes Risk Allele Loci in the Qatari Population. PloS one. 2016 Article GET IT
Times cited: 20
Persistence of circulating endothelial microparticles in COPD despite smoking cessation. Thorax. 2016 Academic Article GET IT
Times cited: 37
Type 2 Diabetes Risk Allele Loci in the Qatari Population. PloS one. 2016 Academic Article GET IT
Times cited: 20
The Qatar genome: a population-specific tool for precision medicine in the Middle East. Human genome variation. 2016 Academic Article GET IT
Times cited: 74
Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy. The Journal of allergy and clinical immunology. 2016 Academic Article GET IT
Times cited: 18
Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels. The European respiratory journal. 2016 Letter GET IT
Times cited: 3
Corrigendum: Open access resources for genome-wide association mapping in rice. Nature communications. 2016 Article GET IT
Times cited: 2
POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 32
Dissection of the genetic architecture of rice resistance to the blast fungus Magnaporthe oryzae. Molecular plant pathology. 2016 Academic Article GET IT
Times cited: 53
Genome-wide association and high-resolution phenotyping link Oryza sativa panicle traits to numerous trait-specific QTL clusters. Nature communications. 2016 Academic Article GET IT
Times cited: 116
Open access resources for genome-wide association mapping in rice. Nature communications. 2016 Academic Article GET IT
Times cited: 298
Cigarette Smoking Induces Changes in Airway Epithelial Expression of Genes Associated with Monogenic Lung Disorders. American journal of respiratory and critical care medicine. 2016 Letter GET IT
Times cited: 7
Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations. Genome research. 2016 Academic Article GET IT
Times cited: 62
Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity. The European respiratory journal. 2015 Academic Article GET IT
Times cited: 83
Copy number variations in the genome of the Qatari population. BMC genomics. 2015 Academic Article GET IT
Times cited: 8
Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation. PloS one. 2015 Academic Article GET IT
Times cited: 56
Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine. 2014 Letter GET IT
Times cited: 70
Smoking accelerates aging of the small airway epithelium. Respiratory research. 2014 Academic Article GET IT
Times cited: 57
lrgpr: interactive linear mixed model analysis of genome-wide association studies with composite hypothesis testing and regression diagnostics in R. Bioinformatics (Oxford, England). 2014 Academic Article GET IT
Times cited: 8
Mesenchymal cell interaction with ovarian cancer cells induces a background dependent pro-metastatic transcriptomic profile. Journal of translational medicine. 2014 Academic Article GET IT
Times cited: 25
Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. PloS one. 2014 Academic Article GET IT
Times cited: 56
HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors. Bioinformatics (Oxford, England). 2013 Academic Article GET IT
Times cited: 17
Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. BMC medical genetics. 2013 Academic Article GET IT
Times cited: 7
Exome sequencing identifies potential risk variants for Mendelian disorders at high prevalence in Qatar. Human mutation. 2013 Academic Article GET IT
Times cited: 41
IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds. Investigative ophthalmology & visual science. 2013 Academic Article GET IT
Times cited: 29
Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations. The American journal of cardiology. 2013 Academic Article GET IT
Times cited: 12
High correlation of the response of upper and lower lobe small airway epithelium to smoking. PloS one. 2013 Academic Article GET IT
Times cited: 5
Spectrum of ocular manifestations in CLN2-associated batten (Jansky-Bielschowsky) disease correlate with advancing age and deteriorating neurological function. PloS one. 2013 Academic Article GET IT
Times cited: 32
Differential expression of vitamin E and selenium-responsive genes by disease severity in chronic obstructive pulmonary disease. COPD. 2013 Academic Article GET IT
Times cited: 8
PUMA: a unified framework for penalized multiple regression analysis of GWAS data. PLoS computational biology. 2013 Academic Article GET IT
Times cited: 30
Lung adenocarcinoma subtypes based on expression of human airway basal cell genes. The European respiratory journal. 2013 Academic Article GET IT
Times cited: 30
Safety of direct cardiac administration of AdVEGF-All6A+, a replication-deficient adenovirus vector cDNA/genomic hybrid expressing all three major isoforms of human vascular endothelial growth factor, to the ischemic myocardium of rats. Human gene therapy. Clinical development. 2013 Academic Article GET IT
Times cited: 9
Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population. PloS one. 2012 Academic Article GET IT
Times cited: 16
Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease. Journal of immunology (Baltimore, Md. : 1950). 2012 Academic Article GET IT
Times cited: 25
PCAdmix: principal components-based assignment of ancestry along each chromosome in individuals with admixed ancestry from two or more populations. Human biology. 2012 Academic Article GET IT
Times cited: 120
Four loci explain 83% of size variation in the horse. PloS one. 2012 Academic Article GET IT
Times cited: 144
Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations. BMC genetics. 2012 Academic Article GET IT
Times cited: 42
Empirical Bayes conditional independence graphs for regulatory network recovery. Bioinformatics (Oxford, England). 2012 Academic Article GET IT
Times cited: 5
Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers. BMC medical genomics. 2012 Academic Article GET IT
Times cited: 44
AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Human gene therapy. 2012 Academic Article GET IT
Times cited: 38
Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies. PLoS genetics. 2012 Academic Article GET IT
Times cited: 97
Mouse obesity network reconstruction with a variational Bayes algorithm to employ aggressive false positive control. BMC bioinformatics. 2012 Academic Article GET IT
Times cited: 21
RNA-Seq quantification of the human small airway epithelium transcriptome. BMC genomics. 2012 Academic Article GET IT
Times cited: 94
Persistent suppression of ocular neovascularization with intravitreal administration of AAVrh.10 coding for bevacizumab. Human gene therapy. 2011 Academic Article GET IT
Times cited: 20
Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa. Nature communications. 2011 Academic Article GET IT
Times cited: 986
Biologic phenotyping of the human small airway epithelial response to cigarette smoking. PloS one. 2011 Academic Article GET IT
Times cited: 60
Fast, exact linkage analysis for categorical traits on arbitrary pedigree designs. Genetic epidemiology. 2011 Academic Article GET IT
Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers. American journal of respiratory and critical care medicine. 2011 Academic Article GET IT
Times cited: 180
Glutathione S-transferase copy number variation alters lung gene expression. The European respiratory journal. 2011 Academic Article GET IT
Times cited: 17
Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer. Cancer research. 2011 Academic Article GET IT
Times cited: 33
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Molecular therapy : the journal of the American Society of Gene Therapy. 2011 Academic Article GET IT
Times cited: 53
Gene expression network reconstruction by convex feature selection when incorporating genetic perturbations. PLoS computational biology. 2010 Academic Article GET IT
Times cited: 53
Bayesian linkage analysis of categorical traits for arbitrary pedigree designs. PloS one. 2010 Academic Article GET IT
Times cited: 4
An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9. Molecular vision. 2010 Academic Article GET IT
Times cited: 35
Threshold of biologic responses of the small airway epithelium to low levels of tobacco smoke. American journal of respiratory and critical care medicine. 2010 Academic Article GET IT
Times cited: 68
Whole-genome SNP association in the horse: identification of a deletion in myosin Va responsible for Lavender Foal Syndrome. PLoS genetics. 2010 Academic Article GET IT
Times cited: 89
A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis. BMC bioinformatics. 2010 Academic Article GET IT
Times cited: 69
A genome-wide linkage scan in German shepherd dogs localizes canine platelet procoagulant deficiency (Scott syndrome) to canine chromosome 27. Gene. 2010 Academic Article GET IT
Times cited: 15
Trachea epithelium as a "canary" for cigarette smoking-induced biologic phenotype of the small airway epithelium. Clinical and translational science. 2009 Academic Article GET IT
Times cited: 14
Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience. 2009 Review GET IT
Times cited: 119
Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking. Molecular medicine (Cambridge, Mass.). 2009 Academic Article GET IT
Times cited: 74
Development and use of DNA archives at veterinary teaching hospitals to investigate the genetic basis of disease in dogs. Journal of the American Veterinary Medical Association. 2009 Review GET IT
Times cited: 12
Coordinated evolution of co-expressed gene clusters in the Drosophila transcriptome. BMC evolutionary biology. 2008 Academic Article GET IT
Times cited: 25
Quantitative trait loci for the circadian clock in Neurospora crassa. Genetics. 2007 Academic Article GET IT
Times cited: 11
Adaptive gene expression divergence inferred from population genomics. PLoS genetics. 2007 Academic Article GET IT
Times cited: 44
Developmental regulation of skull morphology II: ontogenetic dynamics of covariance. Evolution & development. 2006 Academic Article GET IT
Times cited: 66
The dimensionality of genetic variation for wing shape in Drosophila melanogaster. Evolution; international journal of organic evolution. 2005 Academic Article GET IT
Times cited: 161
Evolutionary genomics: codon bias and selection on single genomes. Nature. 2005 Comment GET IT
Times cited: 18
Naturally segregating quantitative trait loci affecting wing shape of Drosophila melanogaster. Genetics. 2004 Academic Article GET IT
Times cited: 59
Automated measurement of Drosophila wings. BMC evolutionary biology. 2003 Academic Article GET IT
Times cited: 133
Comparing G matrices: are common principal components informative?. Genetics. 2003 Academic Article GET IT
Times cited: 40
Interpretation of the results of common principal components analyses. Evolution; international journal of organic evolution. 2002 Academic Article GET IT
Times cited: 87
The test distribution of modularity statistics: a correction and clarification. Genetics. 2001 Letter GET IT
Times cited: 1
Is the genotype-phenotype map modular? A statistical approach using mouse quantitative trait loci data. Genetics. 2000 Academic Article GET IT
Times cited: 121
Modeling the evolution of genetic architecture: A continuum of alleles model with pairwise AxA epistasis. Journal of theoretical biology. 2000 Academic Article GET IT
Times cited: 19
Hox cluster genomics in the horn shark, Heterodontus francisci. Proceedings of the National Academy of Sciences of the United States of America. 2000 Academic Article GET IT
Times cited: 95

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Research

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Funding awarded

Phase IA/IB Study of AAVrh.10hFXN Therapy to Treat the Cardiomyopathy of Friedreich''s Ataxia awarded by National Heart, Lung, & Blood Institute Co-Investigator 2020 - 2025
Rapid Noninvasive Whole-body Imaging of AAV Gene Transfer Vectors awarded by National Institute of Biomedical Imaging & Bioengineering Co-Investigator 2019 - 2024
Clinical Assessment of Anti-cocaine Vaccine dAdGNE in Cocaine Addicts awarded by National Institute on Drug Abuse Co-Investigator 2019 - 2024

Ancillary SOURCE Study: Characterization of Small Airway Basal Cell Biology in Early COPD awarded by National Heart, Lung, & Blood Institute Key Personnel 2023 - 2027

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Background

education and training

Ph.D., Yale University 2000
B.A., University of Pennsylvania 1994

Contact

full name

Jason Mezey

primary email

jgm45@cornell.edu

VIVO Weill Cornell Medical College

Jason Mezey Professor of Genetic Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email