selected publications
- Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells. Cell reports. 2023 Academic Article GET IT
- Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2023 Academic Article GET IT
-
In vivo characterization of sAC null sperm.
Frontiers in cell and developmental biology.
2023
Academic Article
GET IT
Times cited: 120 - Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. Journal of chemical information and modeling. 2023 Academic Article GET IT
- Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential. Frontiers in physiology. 2023 Article GET IT
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On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Nature communications.
2023
Academic Article
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Times cited: 5 -
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
Journal of medicinal chemistry.
2022
Academic Article
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Times cited: 4 -
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Frontiers in physiology.
2022
Academic Article
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Times cited: 92 -
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.
Frontiers in pharmacology.
2022
Academic Article
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Times cited: 92 -
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Molecular human reproduction.
2021
Academic Article
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Times cited: 12 -
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS medicinal chemistry letters.
2021
Academic Article
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Times cited: 8 -
Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase.
Interface focus.
2021
Review
GET IT
Times cited: 126 -
Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation.
Biochimica et biophysica acta. Bioenergetics.
2021
Academic Article
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Times cited: 8 -
Metabolic changes in mouse sperm during capacitation†.
Biology of reproduction.
2020
Academic Article
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Times cited: 34 -
Capacitation increases glucose consumption in murine sperm.
Molecular reproduction and development.
2020
Academic Article
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Times cited: 17 -
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.
Biology of reproduction.
2020
Academic Article
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Times cited: 13 -
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.
Cell metabolism.
2020
Academic Article
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Times cited: 82 -
Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation.
Journal of visualized experiments : JoVE.
2020
Academic Article
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Times cited: 5 -
Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies.
Frontiers in cell and developmental biology.
2019
Academic Article
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Times cited: 57 -
Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH.
Science signaling.
2018
Academic Article
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Times cited: 22 -
Pharmacological modulation of the CO2/HCO3-/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.
Pharmacology & therapeutics.
2018
Review
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Times cited: 37 -
Distinct intracellular sAC-cAMP domains regulate ER Ca2+ signaling and OXPHOS function.
Journal of cell science.
2017
Academic Article
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Times cited: 21 -
Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2017
Academic Article
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Times cited: 11 -
Soluble adenylyl cyclase is essential for proper lysosomal acidification.
The Journal of general physiology.
2016
Academic Article
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Times cited: 27 -
Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.
Scientific reports.
2016
Academic Article
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Times cited: 33 -
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.
Nature chemical biology.
2016
Academic Article
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Times cited: 55 -
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.
Oncotarget.
2016
Academic Article
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Times cited: 15 -
Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.
The Journal of biological chemistry.
2016
Academic Article
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Times cited: 17 -
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
The Journal of experimental medicine.
2015
Academic Article
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Times cited: 74 -
A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.
American journal of respiratory cell and molecular biology.
2014
Academic Article
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Times cited: 25 -
Physiological roles of acid-base sensors.
Annual review of physiology.
2014
Review
GET IT
Times cited: 62 -
The role of soluble adenylyl cyclase in health and disease.
Biochimica et biophysica acta.
2014
Editorial Article
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Times cited: 5 -
Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014
Academic Article
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Times cited: 20 -
A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2014
Academic Article
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Times cited: 27 -
Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction.
Neuroscience.
2014
Academic Article
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Times cited: 56 -
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 94 -
Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism.
Investigative ophthalmology & visual science.
2014
Academic Article
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Times cited: 9 -
pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).
Frontiers in physiology.
2013
Review
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Times cited: 89 -
Thiol changes during epididymal maturation: a link to flagellar angulation in mouse spermatozoa?.
Andrology.
2013
Academic Article
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Times cited: 23 -
Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 77 -
CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 93 -
Pharmacological distinction between soluble and transmembrane adenylyl cyclases.
The Journal of pharmacology and experimental therapeutics.
2013
Academic Article
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Times cited: 73 -
cAMP and mitochondria.
Physiology (Bethesda, Md.).
2013
Review
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Times cited: 126 -
Neuronal expression of soluble adenylyl cyclase in the mammalian brain.
Brain research.
2013
Academic Article
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Times cited: 40 -
High adenylyl cyclase activity and in vivo cAMP fluctuations in corals suggest central physiological role.
Scientific reports.
2013
Academic Article
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Times cited: 17 -
Identification of a haem domain in human soluble adenylate cyclase.
Bioscience reports.
2012
Academic Article
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Times cited: 22 -
Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.
Neuron.
2012
Academic Article
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Times cited: 193 -
Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.
PloS one.
2012
Academic Article
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Times cited: 13 -
Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites.
PloS one.
2012
Academic Article
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Times cited: 21 -
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.
Journal of molecular biology.
2011
Academic Article
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Times cited: 28 -
Role of soluble adenylyl cyclase in the heart.
American journal of physiology. Heart and circulatory physiology.
2011
Review
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Times cited: 24 -
Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 39 -
Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 38 -
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 105 -
The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans.
Eukaryotic cell.
2011
Academic Article
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Times cited: 101 -
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.
The Journal of pharmacology and experimental therapeutics.
2011
Academic Article
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Times cited: 7 -
Intracellular cAMP signaling by soluble adenylyl cyclase.
Kidney international.
2011
Review
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Times cited: 166 -
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling.
Sensors (Basel, Switzerland).
2011
Review
GET IT
Times cited: 37 -
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
PLoS pathogens.
2010
Academic Article
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Times cited: 93 -
Physiological carbon dioxide, bicarbonate, and pH sensing.
Pflugers Archiv : European journal of physiology.
2010
Review
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Times cited: 92 -
Modulation of NaCl absorption by [HCO(3)(-)] in the marine teleost intestine is mediated by soluble adenylyl cyclase.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010
Academic Article
GET IT
Times cited: 53 -
Seniority of the first-treating doctor does not influence the outcome of acute whiplash injury: a prospective cohort study.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society.
2010
Academic Article
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Times cited: 4 -
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases.
The Journal of investigative dermatology.
2010
Academic Article
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Times cited: 41 -
Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis.
Proceedings of the National Academy of Sciences of the United States of America.
2009
Academic Article
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Times cited: 75 -
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation.
Cell metabolism.
2009
Academic Article
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Times cited: 378 -
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells.
The Journal of biological chemistry.
2009
Academic Article
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Times cited: 46 -
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice.
PloS one.
2008
Academic Article
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Times cited: 50 -
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells.
The Journal of general physiology.
2008
Academic Article
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Times cited: 95 -
Structure-based development of novel adenylyl cyclase inhibitors.
Journal of medicinal chemistry.
2008
Academic Article
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Times cited: 26 -
"Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells.
Journal of neuroscience research.
2008
Academic Article
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Times cited: 13 -
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP.
The Journal of general physiology.
2007
Academic Article
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Times cited: 94 -
Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction.
Biochemical and biophysical research communications.
2007
Academic Article
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Times cited: 44 -
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones.
Nature neuroscience.
2006
Academic Article
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Times cited: 88 -
Molecular details of cAMP generation in mammalian cells: a tale of two systems.
Journal of molecular biology.
2006
Review
GET IT
Times cited: 256 -
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.
The Journal of biological chemistry.
2006
Academic Article
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Times cited: 64 -
Autoinhibitory regulation of soluble adenylyl cyclase.
Molecular reproduction and development.
2006
Academic Article
GET IT
Times cited: 46 -
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1.
Eukaryotic cell.
2006
Academic Article
GET IT
Times cited: 139 -
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence.
Current biology : CB.
2005
Academic Article
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Times cited: 337 -
The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.
Developmental cell.
2005
Academic Article
GET IT
Times cited: 328 -
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils.
The Journal of experimental medicine.
2005
Academic Article
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Times cited: 58 -
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen.
The Journal of biological chemistry.
2005
Academic Article
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Times cited: 68 -
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005
Academic Article
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Times cited: 197 -
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment.
Nature structural & molecular biology.
2004
Academic Article
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Times cited: 138 -
The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition.
Protein science : a publication of the Protein Society.
2004
Academic Article
GET IT
Times cited: 10 -
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes.
Development genes and evolution.
2004
Academic Article
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Times cited: 30 -
A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily.
Pharmacogenetics.
2004
Review
GET IT
Times cited: 261 -
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain.
The Journal of cell biology.
2004
Academic Article
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Times cited: 144 -
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.
The Journal of biological chemistry.
2003
Academic Article
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Times cited: 200 -
Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate.
The Journal of biological chemistry.
2003
Academic Article
GET IT
Times cited: 284 -
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium.
American journal of physiology. Cell physiology.
2003
Academic Article
GET IT
Times cited: 36 -
Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2002
Academic Article
GET IT
Times cited: 244 -
Different pathways of cell killing by gossypol enantiomers.
Experimental biology and medicine (Maywood, N.J.).
2002
Academic Article
GET IT
Times cited: 53 -
Purification of soluble adenylyl cyclase.
Methods in enzymology.
2002
Academic Article
GET IT
Times cited: 10 -
CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor.
Trends in endocrinology and metabolism: TEM.
2001
Review
GET IT
Times cited: 96 -
Bicarbonate-regulated soluble adenylyl cyclase.
JOP : Journal of the pancreas.
2001
Review
GET IT
Times cited: 63 -
A helical lid converts a sulfotransferase to a dehydratase.
Nature structural biology.
2001
Academic Article
GET IT
Times cited: 29 -
Crystallization of retinol dehydratase from Spodoptera frugiperda: improvement of crystal quality by modification by ethylmercurythiosalicylate.
Acta crystallographica. Section D, Biological crystallography.
2000
Academic Article
GET IT
Times cited: 9 -
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.
Science (New York, N.Y.).
2000
Academic Article
GET IT
Times cited: 691 -
Cannabinoids protect cells from oxidative cell death: a receptor-independent mechanism.
The Journal of pharmacology and experimental therapeutics.
2000
Academic Article
GET IT
Times cited: 107 -
Specific expression of soluble adenylyl cyclase in male germ cells.
Molecular reproduction and development.
2000
Academic Article
GET IT
Times cited: 108 -
Anhydroretinol induces oxidative stress and cell death.
Cancer research.
1999
Academic Article
GET IT
Times cited: 49 -
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals.
Proceedings of the National Academy of Sciences of the United States of America.
1999
Academic Article
GET IT
Times cited: 426 -
Substrate specificity and kinetic mechanism of the insect sulfotransferase, retinol dehydratase.
The Journal of biological chemistry.
1998
Academic Article
GET IT
Times cited: 26 -
Vitamin A in serum is a survival factor for fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America.
1997
Academic Article
GET IT
Times cited: 25 -
The level of lipopolysaccharide-binding protein is significantly increased in plasma in patients with the systemic inflammatory response syndrome.
Clinical and diagnostic laboratory immunology.
1997
Academic Article
GET IT
Times cited: 60 -
Retro-retinoids in regulated cell growth and death.
The Journal of experimental medicine.
1996
Academic Article
GET IT
Times cited: 56 -
Purification, cloning, and bacterial expression of retinol dehydratase from Spodoptera frugiperda.
The Journal of biological chemistry.
1996
Academic Article
GET IT
Times cited: 22 -
4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.
Proceedings of the National Academy of Sciences of the United States of America.
1996
Academic Article
GET IT
Times cited: 98 -
Novel retinoic acid receptor ligands in Xenopus embryos.
Proceedings of the National Academy of Sciences of the United States of America.
1996
Academic Article
GET IT
Times cited: 100 -
Retinoic acid-induced increase in delta-opioid receptor and N-methyl-D-aspartate receptor mRNA levels in neuroblastoma x glioma (NG108-15) cells.
Brain research bulletin.
1996
Academic Article
GET IT
Times cited: 23 -
13,14-Dihydroxy-retinol, a new bioactive retinol metabolite.
The Journal of biological chemistry.
1995
Academic Article
GET IT
Times cited: 41 -
Intracellular signaling activity of synthetic (14R)-, (14S)-, and (14RS)-14-hydroxy-4,14-retro-retinol.
Biochemistry.
1994
Academic Article
GET IT
Times cited: 44 -
Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells.
The Journal of experimental medicine.
1993
Academic Article
GET IT
Times cited: 44 -
9-cis and all-trans retinoic acid induce a similar phenotype in human teratocarcinoma cells.
Differentiation; research in biological diversity.
1993
Academic Article
GET IT
Times cited: 26 -
Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.
The Journal of experimental medicine.
1993
Academic Article
GET IT
Times cited: 90 -
Retinoids are important cofactors in T cell activation.
The Journal of experimental medicine.
1992
Academic Article
GET IT
Times cited: 109 -
Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.
Molecular biology of the cell.
1992
Academic Article
GET IT
Times cited: 276 -
Intracellular signaling by 14-hydroxy-4,14-retro-retinol.
Science (New York, N.Y.).
1991
Academic Article
GET IT
Times cited: 172 -
Differences in the action and metabolism between retinol and retinoic acid in B lymphocytes.
The Journal of cell biology.
1991
Academic Article
GET IT
Times cited: 54 -
The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.
Cell.
1990
Academic Article
GET IT
Times cited: 941 -
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.
The EMBO journal.
1990
Academic Article
GET IT
Times cited: 243 -
Unisex Flash Controls in Dialog Fireflies.
The Biological bulletin.
1990
Academic Article
GET IT
Times cited: 5 -
Retinol is essential for growth of activated human B cells.
The Journal of experimental medicine.
1990
Academic Article
GET IT
Times cited: 79 -
A novel autoregulatory cytokine is required for the regulation of autoaggressive responses.
Human immunology.
1990
Academic Article
GET IT
Times cited: 2 -
Cytotoxic effects of m-[131I]- and m-[125I]iodobenzylguanidine on the human neuroblastoma cell lines SK-N-SH and SK-N-LO.
Cancer research.
1988
Academic Article
GET IT
Times cited: 30 -
Purification and biochemical characterization of a human autocrine growth factor produced by Epstein-Barr virus-transformed B cells.
Journal of immunology (Baltimore, Md. : 1950).
1987
Academic Article
GET IT
Times cited: 19 - [Angiocinedensitometry with ECG-controlled injections in patients with healthy kidneys and kidney tumors]. Der Radiologe. 1986 Academic Article GET IT
-
Clinical experiences in the treatment of neuroblastoma with 131I-metaiodobenzylguanidine.
Pediatric hematology and oncology.
1986
Academic Article
GET IT
Times cited: 40 -
Specific uptake of m-[125I]iodobenzylguanidine in the human neuroblastoma cell line SK-N-SH.
Cancer research.
1985
Academic Article
GET IT
Times cited: 82 -
The role of reactive oxygen compounds derived from 6-hydroxydopamine for bone marrow purging from neuroblastoma cells.
Biochemical and biophysical research communications.
1985
Academic Article
GET IT
Times cited: 13 -
The combined effect of interferon-beta and cytostatic drugs on human tumor cell lines in vitro.
Journal of interferon research.
1985
Academic Article
GET IT
Times cited: 8