Strategies to safely target widely expressed soluble adenylyl cyclase for contraception. Academic Article uri icon

Overview

abstract

  • In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.

publication date

  • August 25, 2022

Identity

PubMed Central ID

  • PMC9452739

Scopus Document Identifier

  • 84887851869

Digital Object Identifier (DOI)

  • 10.1074/jbc.M113.510073

PubMed ID

  • 36091839

Additional Document Info

volume

  • 13