Zhou, Joe

Publications

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selected publications

Clonal evolution during metastatic spread in high-risk neuroblastoma. Nature genetics. 2023 Academic Article GET IT
Generation of gastirc insulin-secreting organoids from human stomach sample. Research square. 2023 Article GET IT
Times cited: 8
Stomach-derived human insulin-secreting organoids restore glucose homeostasis. Nature cell biology. 2023 Academic Article GET IT
Times cited: 1
Matrix viscoelasticity controls spatiotemporal tissue organization. Nature materials. 2022 Academic Article GET IT
Times cited: 64
In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system. Cell chemical biology. 2022 Academic Article GET IT
Times cited: 1
Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells. Cellular reprogramming. 2022 Review GET IT
Rapid establishment of human colonic organoid knockout lines. STAR protocols. 2022 Academic Article GET IT
Times cited: 3
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell stem cell. 2021 Academic Article GET IT
Times cited: 9
Author Correction: PDX1^LOW MAFA^LOW β-cells contribute to islet function and insulin release. Nature communications. 2021 Article GET IT
Times cited: 1
Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas. Nature metabolism. 2021 Academic Article GET IT
Times cited: 23
PDX1^LOW MAFA^LOW β-cells contribute to islet function and insulin release. Nature communications. 2021 Academic Article GET IT
Times cited: 33
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Nature. 2020 Academic Article GET IT
Times cited: 102
Author Correction: Pancreas regeneration. Nature. 2018 Academic Article GET IT
Pancreas regeneration. Nature. 2018 Review GET IT
Times cited: 203
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem cell reports. 2017 Academic Article GET IT
Times cited: 71
Reprogramming of Pancreatic Acinar Cells to Functional Beta Cells by In Vivo Transduction of a Polycistronic Construct Containing Pdx1, Ngn3, MafA in Mice. Current protocols in stem cell biology. 2017 Academic Article GET IT
Times cited: 8
Regenerative medicine: Interspecies pancreas transplants. Nature. 2017 Comment GET IT
Times cited: 2
How to make insulin-producing pancreatic β cells for diabetes treatment. Science China. Life sciences. 2016 Review GET IT
Times cited: 16
Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. Cell stem cell. 2016 Academic Article GET IT
Times cited: 93
Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice. Diabetologia. 2015 Academic Article GET IT
Times cited: 25
Corrigendum: Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells. Nature biotechnology. 2015 Article GET IT
Times cited: 1
Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells. Endocrinology. 2015 Academic Article GET IT
Times cited: 25
Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes. Current pathobiology reports. 2015 Academic Article GET IT
Times cited: 11
Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells. Nature biotechnology. 2014 Academic Article GET IT
Times cited: 80
De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts. Cell reports. 2014 Academic Article GET IT
Times cited: 113
Direct lineage conversion of pancreatic exocrine to endocrine Beta cells in vivo with defined factors. Methods in molecular biology (Clifton, N.J.). 2014 Academic Article GET IT
Times cited: 11
In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. eLife. 2014 Academic Article GET IT
Times cited: 87
How to remake a fibroblast into a neural stem cell. Cell stem cell. 2012 Comment GET IT
Times cited: 18
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (Cambridge, England). 2009 Academic Article GET IT
Times cited: 225
Extreme makeover: converting one cell into another. Cell stem cell. 2008 Review GET IT
Times cited: 196
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008 Academic Article GET IT
Times cited: 1670
Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell. 2008 Academic Article GET IT
Times cited: 249
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (Cambridge, England). 2008 Academic Article GET IT
Times cited: 123
Genetic targeting of the endoderm with claudin-6CreER. Developmental dynamics : an official publication of the American Association of Anatomists. 2008 Academic Article GET IT
Times cited: 45
Pathways to new beta cells. Cold Spring Harbor symposia on quantitative biology. 2008 Review GET IT
Times cited: 17
A multipotent progenitor domain guides pancreatic organogenesis. Developmental cell. 2007 Academic Article GET IT
Times cited: 415
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell. 2002 Academic Article GET IT
Times cited: 849
The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron. 2001 Academic Article GET IT
Times cited: 479
Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 2000 Academic Article GET IT
Times cited: 638

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Research

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Co-investigator Network

Funding awarded

Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapy awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2022 - 2026
Derivation of pancreatic islet-like organoids from human gastric stem cells awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2022 - 2026
Investigating a master regulator of large intestine stem cells awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2021 - 2025
Developing a novel cell therapy to treat Type 1 diabetes awarded by Daedalus Fund for Innovation (Weill Cornell) Principal Investigator 2022 - 2024
Addgene 700445 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Addgene 694737 awarded by Addgene, Inc. Principal Investigator 2022 - 2023

Adaptable tissue-specific endothelial cells for organ regeneration awarded by National Heart, Lung, & Blood Institute Co-Investigator 2020 - 2027
Subcutaneous Transplantation of Pre-Vascularized Human Islets and SC-β cells to Treat Type I Diabetes awarded by JDRF Co-Investigator 2022 - 2024

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Background

education and training

Ph.D., California Institute of Technology 2003
M.S., Boston University 1997
B.S., Qingdao University 1993

Contact

full name

Joe Zhou

primary email

jqz4001@med.cornell.edu

VIVO Weill Cornell Medical College

Joe Zhou Associate Professor of Regenerative Medicine in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email