Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes. Academic Article uri icon

Overview

abstract

  • Direct reprogramming is a promising approach for regenerative medicine whereby one cell type is directly converted into another without going through a multipotent or pluripotent stage. This reprogramming approach has been extensively explored for the generation of functional insulin-secreting cells from non-beta-cells with the aim of developing novel cell therapies for the treatment of people with diabetes lacking sufficient endogenous beta-cells. A common approach for such conversion studies is the introduction of key regulators that are important in controlling beta-cell development and maintenance. In this review, we will summarize the recent advances in the field of beta-cell reprogramming and discuss the challenges of creating functional and long-lasting beta-cells.

publication date

  • January 30, 2015

Identity

PubMed Central ID

  • PMC4797339

Scopus Document Identifier

  • 85019371979

Digital Object Identifier (DOI)

  • 10.1007/s40139-015-0068-0

PubMed ID

  • 26998407

Additional Document Info

volume

  • 3

issue

  • 1