Hsu, Katharine

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selected publications

Dominant epitopes presented by prevalent HLA alleles permit wide use of banked CMVpp65 T cells in adoptive therapy. Blood advances. 2022 Academic Article GET IT
Times cited: 4
Corrigendum: Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia. Frontiers in immunology. 2021 Article GET IT
Times cited: 1
Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Science signaling. 2021 Academic Article GET IT
Times cited: 9
Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3⁺ NK Cell Subset with a Bcl11b-Regulated T Cell Signature. Journal of immunology (Baltimore, Md. : 1950). 2021 Academic Article GET IT
Times cited: 1
Human cytomegalovirus expands a CD8⁺ T cell population with loss of BCL11B expression and gain of NK cell identity. Science immunology. 2021 Academic Article GET IT
Times cited: 14
Deconvoluting global cytokine signaling networks in natural killer cells. Nature immunology. 2021 Academic Article GET IT
Times cited: 17
Prospective KIR genotype evaluation of hematopoietic cell donors is feasible with potential to benefit patients with AML. Blood advances. 2021 Academic Article GET IT
Times cited: 4
Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. Immunity. 2021 Academic Article GET IT
Times cited: 32
High progression-free survival after intermediate intensity double unit cord blood transplantation in adults. Blood advances. 2020 Academic Article GET IT
Times cited: 12
Selection of allogeneic hematopoietic cell transplant donors to optimize natural killer cell alloreactivity. Seminars in hematology. 2020 Academic Article GET IT
Times cited: 6
HLA-A alleles influencing NK cell function impact AML relapse following allogeneic hematopoietic cell transplantation. Blood advances. 2020 Academic Article GET IT
Times cited: 9
Specific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Supertypes Impact Allogeneic HCT Outcomes. Transplantation and cellular therapy. 2020 Academic Article GET IT
Times cited: 2
Prognostic impact of serum CXC chemokine ligands 4 and 7 on myelodysplastic syndromes post allogeneic hematopoietic cell transplant. Leukemia & lymphoma. 2020 Letter GET IT
HLA-B leader and survivorship after HLA-mismatched unrelated donor transplantation. Blood. 2020 Academic Article GET IT
Times cited: 25
Engraftment kinetics after transplantation of double unit cord blood grafts combined with haplo-identical CD34+ cells without antithymocyte globulin. Leukemia. 2020 Academic Article GET IT
Times cited: 7
Investigation of donor KIR content and matching in children undergoing hematopoietic cell transplantation for acute leukemia. Blood advances. 2020 Academic Article GET IT
Times cited: 13
Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 111
Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study. The Lancet. Haematology. 2019 Academic Article GET IT
Times cited: 43
Publisher Correction: Novel multiplex PCR-SSP method for centromeric KIR allele discrimination. Scientific reports. 2019 Article GET IT
Donor HLA-E Status Associates with Disease-Free Survival and Transplant-Related Mortality after Non In Vivo T Cell-Depleted HSCT for Acute Leukemia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2019 Academic Article GET IT
Times cited: 8
Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells. Immunity. 2019 Academic Article GET IT
Times cited: 32
Novel Approach to Cell Surface Discrimination Between KIR2DL1 Subtypes and KIR2DS1 Identifies Hierarchies in NK Repertoire, Education, and Tolerance. Frontiers in immunology. 2019 Academic Article GET IT
Times cited: 19
Analysis of Single Nucleotide Polymorphisms in the Gamma Block of the Major Histocompatibility Complex in Association with Clinical Outcomes of Hematopoietic Cell Transplantation: A Center for International Blood and Marrow Transplant Research Study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018 Academic Article GET IT
Times cited: 3
Novel multiplex PCR-SSP method for centromeric KIR allele discrimination. Scientific reports. 2018 Academic Article GET IT
Times cited: 4
The effect of NIMA matching in adult unrelated mismatched hematopoietic stem cell transplantation - a joint study of the Acute Leukemia Working Party of the EBMT and the CIBMTR. Bone marrow transplantation. 2018 Academic Article GET IT
Donor-specific anti-HLA antibodies in unrelated hematopoietic cell transplantation for non-malignant disorders. Bone marrow transplantation. 2018 Letter GET IT
Times cited: 4
In silico prediction of nonpermissive HLA-DPB1 mismatches in unrelated HCT by functional distance. Blood advances. 2018 Academic Article GET IT
Times cited: 17
Prevention of relapse after allogeneic hematopoietic cell transplantation by donor and cell source selection. Bone marrow transplantation. 2018 Review GET IT
Times cited: 7
Adoptive immunotherapy with haploidentical natural killer cells and Anti-GD2 monoclonal antibody m3F8 for resistant neuroblastoma: Results of a phase I study. Oncoimmunology. 2018 Academic Article GET IT
Times cited: 54
Development of an Unrelated Donor Selection Score Predictive of Survival after HCT: Donor Age Matters Most. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018 Academic Article GET IT
Times cited: 71
Natural killer cell education in human health and disease. Current opinion in immunology. 2018 Review GET IT
Times cited: 80
Evaluation of a Machine Learning-Based Prognostic Model for Unrelated Hematopoietic Cell Transplantation Donor Selection. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018 Academic Article GET IT
Times cited: 10
Natural Killer Cell Education and the Response to Infection and Cancer Therapy: Stay Tuned. Trends in immunology. 2018 Review GET IT
Times cited: 104
Prediction of absolute risk of acute graft-versus-host disease following hematopoietic cell transplantation. PloS one. 2018 Academic Article GET IT
Times cited: 17
No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia. Bone marrow transplantation. 2017 Academic Article GET IT
Times cited: 9
Impact of HLA Alleles on Outcomes of Allogeneic Transplantation for B Cell Non-Hodgkin Lymphomas: A Center for International Blood and Marrow Transplant Research Analysis. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2017 Academic Article GET IT
Times cited: 1
Genotyping Natural Killer Immune Checkpoints to Discover Biomarkers of Response. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017 Comment GET IT
Times cited: 2
A Chemotherapy-Only Regimen of Busulfan, Melphalan, and Fludarabine, and Rabbit Antithymocyte Globulin Followed by Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplantations for the Treatment of Myeloid Malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2017 Academic Article GET IT
Times cited: 4
Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis. The Lancet. Haematology. 2017 Academic Article GET IT
Times cited: 62
KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Academic Article GET IT
Times cited: 83
Investigating the Association of Genetic Admixture and Donor/Recipient Genetic Disparity with Transplant Outcomes. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2017 Academic Article GET IT
Times cited: 6
Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation. The New England journal of medicine. 2017 Academic Article GET IT
Times cited: 451
MHC Class I Chain-Related Gene A (MICA) Donor-Recipient Mismatches and MICA-129 Polymorphism in Unrelated Donor Hematopoietic Cell Transplantations Has No Impact on Outcomes in Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome: A Center for International Blood and Marrow Transplant Research Study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 15
Human Dendritic Cells Mitigate NK-Cell Dysfunction Mediated by Nonselective JAK1/2 Blockade. Cancer immunology research. 2016 Academic Article GET IT
Times cited: 28
How important is NK alloreactivity and KIR in allogeneic transplantation?. Best practice & research. Clinical haematology. 2016 Review GET IT
Times cited: 28
Recipient HLA-C Haplotypes and microRNA 148a/b Binding Sites Have No Impact on Allogeneic Hematopoietic Cell Transplantation Outcomes. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 12
Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I. Immunity. 2016 Academic Article GET IT
Times cited: 49
Validation Study Failed to Confirm an Association between Genetic Variants in the Base Excision Repair Pathway and Transplant-Related Mortality and Relapse after Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Letter GET IT
Times cited: 6
KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016 Academic Article GET IT
Times cited: 58
KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 85
Phase II Study of Haploidentical Natural Killer Cell Infusion for Treatment of Relapsed or Persistent Myeloid Malignancies Following Allogeneic Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 101
High Disease-Free Survival with Enhanced Protection against Relapse after Double-Unit Cord Blood Transplantation When Compared with T Cell-Depleted Unrelated Donor Transplantation in Patients with Acute Leukemia and Chronic Myelogenous Leukemia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 32
KIR3DS1-Specific D0 Domain Polymorphisms Disrupt KIR3DL1 Surface Expression and HLA Binding. Journal of immunology (Baltimore, Md. : 1950). 2015 Academic Article GET IT
Times cited: 11
Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 30
Donor activating KIR2DS1 in leukemia. The New England journal of medicine. 2014 Letter GET IT
Times cited: 12
High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation. Blood. 2014 Academic Article GET IT
Times cited: 86
HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation. Blood. 2014 Academic Article GET IT
Times cited: 119
KIR and HLA genotypes have no identifiable role in single-unit dominance following double-unit umbilical cord blood transplantation. Bone marrow transplantation. 2014 Academic Article GET IT
Times cited: 8
Phenotypic and functional activation of hyporesponsive KIRnegNKG2Aneg human NK-cell precursors requires IL12p70 provided by Poly(I:C)-matured monocyte-derived dendritic cells. Cancer immunology research. 2014 Academic Article GET IT
Times cited: 5
CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. Cancer immunology research. 2014 Academic Article GET IT
Times cited: 42
Development of a novel multiplex PCR assay to detect functional subtypes of KIR3DL1 alleles. PloS one. 2014 Academic Article GET IT
Times cited: 31
BRAF V600E mutation and clonal evolution in a patient with relapsed refractory myeloma with plasmablastic differentiation. 2013 GET IT
Times cited: 19
Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation: part II. Autologous Transplantation-novel agents and immunomodulatory strategies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Conference Paper GET IT
Times cited: 9
NK cell tolerance of self-specific activating receptor KIR2DS1 in individuals with cognate HLA-C2 ligand. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 50
16th IHIW: international histocompatibility working group in hematopoietic cell transplantation. International journal of immunogenetics. 2012 Conference Paper GET IT
Times cited: 22
T cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012 Academic Article GET IT
Times cited: 33
HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1. The New England journal of medicine. 2012 Academic Article GET IT
Times cited: 330
Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 173
Activation of peripheral-blood granulocytes is strongly correlated with patient outcome after immunotherapy with anti-GD2 monoclonal antibody and granulocyte-macrophage colony-stimulating factor. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011 Academic Article GET IT
Times cited: 49
Killer immunoglobulin-like receptor locus polymorphisms in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). 2011 Academic Article GET IT
Times cited: 18
Reduced late mortality risk contributes to similar survival after double-unit cord blood transplantation compared with related and unrelated donor hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Academic Article GET IT
Times cited: 66
T cell-depleted unrelated donor stem cell transplantation provides favorable disease-free survival for adults with hematologic malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Academic Article GET IT
Times cited: 65
Donor activating KIR3DS1 is associated with decreased acute GVHD in unrelated allogeneic hematopoietic stem cell transplantation. Blood. 2010 Academic Article GET IT
Times cited: 84
Second-line age-adjusted International Prognostic Index in patients with advanced non-Hodgkin lymphoma after T-cell depleted allogeneic hematopoietic SCT. Bone marrow transplantation. 2010 Academic Article GET IT
Times cited: 19
KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Academic Article GET IT
Times cited: 101
Natural killer cells: tolerance to self and innate immunity to viral infection and malignancy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2009 Review GET IT
Times cited: 16
Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell-depleted allogeneic hematopoietic cell transplantation. Blood. 2009 Academic Article GET IT
Times cited: 111
Infusion of haplo-identical killer immunoglobulin-like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation. British journal of haematology. 2008 Academic Article GET IT
Times cited: 162
Rituximab-responsive Guillain-Barré syndrome following allogeneic hematopoietic SCT. Bone marrow transplantation. 2008 Letter GET IT
Times cited: 24
Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2008 Academic Article GET IT
Times cited: 54
HLA alleles determine differences in human natural killer cell responsiveness and potency. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 213
Hierarchy of the human natural killer cell response is determined by class and quantity of inhibitory receptors for self-HLA-B and HLA-C ligands. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 163
Fludarabine-based conditioning secures engraftment of second hematopoietic stem cell allografts (HSCT) in the treatment of initial graft failure. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2007 Academic Article GET IT
Times cited: 41
T cell depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin. Blood. 2007 Academic Article GET IT
Times cited: 99
KIR2DS1-positive NK cells mediate alloresponse against the C2 HLA-KIR ligand group in vitro. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 161
14thInternational HLA and Immunogenetics Workshop: report on hematopoietic cell transplantation. Tissue antigens. 2007 Conference Paper GET IT
Times cited: 4
Hematopoietic stem cell transplantation: killer immunoglobulin-like receptor component. Tissue antigens. 2007 Academic Article GET IT
Times cited: 19
Intravenous busulfan and melphalan, tacrolimus, and short-course methotrexate followed by unmodified HLA-matched related or unrelated hematopoietic stem cell transplantation for the treatment of advanced hematologic malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2007 Academic Article GET IT
Times cited: 24
KIR ligands and prediction of relapse after unrelated donor hematopoietic cell transplantation for hematologic malignancy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2006 Academic Article GET IT
Times cited: 177
TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Annals of the New York Academy of Sciences. 2005 Academic Article GET IT
Times cited: 182
Natural killer cell receptors: regulating innate immune responses to hematologic malignancy. Seminars in hematology. 2005 Review GET IT
Times cited: 28
Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes. Blood. 2005 Academic Article GET IT
Times cited: 411
Inhibitory killer Ig-like receptor genes and human leukocyte antigen class I ligands in haematopoietic stem cell transplantation. Current opinion in immunology. 2004 Review GET IT
Times cited: 57
[Killer Ig-like receptor gene content diversity and haplotype analysis in Chinese Han population in Shanghai]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 2003 Academic Article GET IT
Times cited: 17
Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. Tissue antigens. 2003 Academic Article GET IT
Times cited: 220
Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. Immunogenetics. 2003 Conference Paper GET IT
Times cited: 91
Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. Human immunology. 2003 Academic Article GET IT
Times cited: 87
Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002. European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 2003 Academic Article GET IT
Times cited: 14
The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunological reviews. 2002 Review GET IT
Times cited: 363
Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 357
Upregulation of NF-kappa B-dependent gene expression mediated by the p75 tumor necrosis factor receptor. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 1995 Academic Article GET IT
Times cited: 32
Differential expression and ligand binding properties of tumor necrosis factor receptor chimeric mutants. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 23

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Funding awarded

Weill Cornell/Rockefeller/Sloan Kettering MST Program awarded by National Institute of General Medical Sciences Principal Investigator 2019 - 2024

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Background

education and training

M.D., Cornell University Medical College 1994
Ph.D., Cornell University Graduate School of Medical Sciences 1993
B.S., M.S., Stanford University 1987

Contact

full name

Katharine Hsu

primary email

kch2005@med.cornell.edu

VIVO Weill Cornell Medical College

Katharine Hsu Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email