Genotyping Natural Killer Immune Checkpoints to Discover Biomarkers of Response. uri icon

Overview

abstract

  • Immune checkpoints have been a focus of immunotherapy in the recent decade. Killer cell immunoglobulin-like receptors (KIR) and their cognate human leukocyte antigen (HLA) class I ligands have evolved as checkpoints to ensure self-tolerance of natural killer cells. Both KIR and HLA genetic profiles are potential biomarkers of immunotherapy outcome. Clin Cancer Res; 24(1); 3-5. ©2017 AACRSee related article by Erbe et al., p. 189.

publication date

  • November 9, 2017

Research

keywords

  • Genotype
  • Neuroblastoma

Identity

PubMed Central ID

  • PMC5754255

Scopus Document Identifier

  • 85040086198

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-17-2884

PubMed ID

  • 29122934

Additional Document Info

volume

  • 24

issue

  • 1