Kirkman, Laura

Publications

Sort by

Co-Author Network

selected publications

Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance. Cell chemical biology. 2023 Academic Article GET IT
Times cited: 1
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell chemical biology. 2023 Academic Article GET IT
Times cited: 1
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II. Journal of medicinal chemistry. 2023 Academic Article GET IT
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors. Antimicrobial agents and chemotherapy. 2022 Academic Article GET IT
Times cited: 3
Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors. Journal of medicinal chemistry. 2022 Academic Article GET IT
Times cited: 2
Use of tafenoquine to treat a patient with relapsing babesiosis with clinical and molecular evidence of resistance to azithromycin and atovaquone. 2022 GET IT
Times cited: 63
Can repurposing drugs play a role in malaria control?. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 3
Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature. 2021 GET IT
Times cited: 3
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice. Angewandte Chemie (International ed. in English). 2021 Academic Article GET IT
Times cited: 13
Telomere length dynamics in response to DNA damage in malaria parasites. iScience. 2021 Academic Article GET IT
Times cited: 1
The contribution of extrachromosomal DNA to genome plasticity in malaria parasites. Molecular microbiology. 2020 Article GET IT
Times cited: 1
Case Report: Mucosal Leishmaniasis in New York City. 2020 GET IT
Times cited: 4
A Histone Methyltransferase Inhibitor Can Reverse Epigenetically Acquired Drug Resistance in the Malaria Parasite Plasmodium falciparum. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 7
Vive la Différence: Exploiting the Differences between Rodent and Human Malarias. Trends in parasitology. 2020 Review GET IT
Times cited: 4
Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance. mBio. 2020 Academic Article GET IT
Times cited: 10
Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. Journal of medicinal chemistry. 2019 Academic Article GET IT
Times cited: 25
Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum. PLoS biology. 2019 Academic Article GET IT
Times cited: 27
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 51
Clinical and Molecular Evidence of Atovaquone and Azithromycin Resistance in Relapsed Babesia microti Infection Associated With Rituximab and Chronic Lymphocytic Leukemia. 2017 GET IT
Times cited: 39
Chromosome End Repair and Genome Stability in Plasmodium falciparum. mBio. 2017 Academic Article GET IT
Times cited: 17
Babesia microti: from Mice to Ticks to an Increasing Number of Highly Susceptible Humans. Journal of clinical microbiology. 2017 Review GET IT
Times cited: 40
Plasmodium falciparum K76T pfcrt Gene Mutations and Parasite Population Structure, Haiti, 2006-2009. Emerging infectious diseases. 2016 Academic Article GET IT
Times cited: 9
Cutaneous Leishmaniasis: Current Treatment Practices in the USA for Returning Travelers. Current treatment options in infectious diseases. 2015 Academic Article GET IT
The molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations. Annals of the New York Academy of Sciences. 2015 Review GET IT
Times cited: 41
Recombination and Diversification of the Variant Antigen Encoding Genes in the Malaria Parasite Plasmodium falciparum. Microbiology spectrum. 2014 Review GET IT
Times cited: 10
Origin of robustness in generating drug-resistant malaria parasites. Molecular biology and evolution. 2014 Academic Article GET IT
Times cited: 33
Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity. Nucleic acids research. 2013 Academic Article GET IT
Times cited: 71
Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum. Molecular microbiology. 2013 Academic Article GET IT
Times cited: 45
Antigenic variation and the generation of diversity in malaria parasites. Current opinion in microbiology. 2012 Review GET IT
Times cited: 35
Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum. International journal for parasitology. 2008 Academic Article GET IT
Times cited: 48
[In vitro cultivation of fields isolates of Plasmodium falciparum in Mali]. Bulletin de la Societe de pathologie exotique (1990). 2007 Academic Article GET IT
Times cited: 4
A large outbreak of histoplasmosis among American travelers associated with a hotel in Acapulco, Mexico, spring 2001. The American journal of tropical medicine and hygiene. 2003 Academic Article GET IT
Times cited: 50
Cyclic nucleotide signaling in Toxoplasma gondii bradyzoite differentiation. Infection and immunity. 2001 Academic Article GET IT
Times cited: 61
Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell. 1997 Academic Article GET IT
Times cited: 328
Plasmodium falciparum: isolation of large numbers of parasite clones from infected blood samples. Experimental parasitology. 1996 Academic Article GET IT
Times cited: 34
Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 340
An analysis of vincristine-resistance in BHK cells pretreated with 1-beta-D-arabinofuranosylcytosine. Anticancer research. 1993 Academic Article GET IT
Times cited: 2

more ...

less ...

Research

Sort by

Co-investigator Network

Funding awarded

Role of Translesional Polymerases in Genome Diversification of the Malaria Parasite awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2024
Role of Translesional Polymerases in Genome Diversification of the Malaria Parasite awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2019 - 2024

Hijacking Plasmodium ubiquitin-proteasome system to defeat drug resistance awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2023 - 2028
Targeting the Plasmodium proteasome for prophylaxis and treatment of drug-resistant malaria in US Military personnel awarded by United States Department of Defense Co-Investigator 2022 - 2024
Selective Plasmodium proteasome inhibitors as novel multi-stage antimalarials awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2019 - 2024
Compounds that force Plasmodium falciparum to produce its own inhibitors awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2020 - 2023

more ...

less ...

Background

education and training

M.D., Albert Einstein College of Medicine of Yeshiva University 2001
B.A., Swarthmore College 1993

Contact

full name

Laura Kirkman

primary email

lak9015@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Laura Kirkman Associate Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage