Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Academic Article uri icon

Overview

abstract

  • Chloroquine resistance in a P. falciparum cross maps as a Mendelian trait to a 36 kb segment of chromosome 7. This segment harbors cg2, a gene encoding a unique approximately 330 kDa protein with complex polymorphisms. A specific set of polymorphisms in 20 chloroquine-resistant parasites from Asia and Africa, in contrast with numerous differences in 21 sensitive parasites, suggests selection of a cg2 allele originating in Indochina over 40 years ago. One chloroquine-sensitive clone exhibited this allele, suggesting another resistance component. South American parasites have cg2 polymorphisms consistent with a separate origin of resistance. CG2 protein is found at the parasite periphery, a site of chloroquine transport, and in association with hemozoin of the digestive vacuole, where chloroquine inhibits heme polymerization.

publication date

  • November 28, 1997

Research

keywords

  • Antimalarials
  • Chloroquine
  • Plasmodium falciparum
  • Protozoan Proteins

Identity

Scopus Document Identifier

  • 0031589733

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)80447-x

PubMed ID

  • 9393853

Additional Document Info

volume

  • 91

issue

  • 5