Levin, Lonny R.

Publications

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selected publications

Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells. Cell reports. 2023 Academic Article GET IT
Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2023 Academic Article GET IT
In vivo characterization of sAC null sperm. Frontiers in cell and developmental biology. 2023 Academic Article GET IT
Times cited: 120
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. Journal of chemical information and modeling. 2023 Academic Article GET IT
Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential. Frontiers in physiology. 2023 Article GET IT
On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nature communications. 2023 Academic Article GET IT
Times cited: 5
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. Journal of medicinal chemistry. 2022 Academic Article GET IT
Times cited: 4
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential. Frontiers in physiology. 2022 Academic Article GET IT
Times cited: 92
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception. Frontiers in pharmacology. 2022 Academic Article GET IT
Times cited: 92
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization. Molecular human reproduction. 2021 Academic Article GET IT
Times cited: 12
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS medicinal chemistry letters. 2021 Academic Article GET IT
Times cited: 8
Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase. Interface focus. 2021 Review GET IT
Times cited: 126
Soluble adenylyl cyclase regulates the cytosolic NADH/NAD⁺ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation. Biochimica et biophysica acta. Bioenergetics. 2021 Academic Article GET IT
Times cited: 8
Metabolic changes in mouse sperm during capacitation†. Biology of reproduction. 2020 Academic Article GET IT
Times cited: 34
Capacitation increases glucose consumption in murine sperm. Molecular reproduction and development. 2020 Academic Article GET IT
Times cited: 17
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†. Biology of reproduction. 2020 Academic Article GET IT
Times cited: 13
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell metabolism. 2020 Academic Article GET IT
Times cited: 82
Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation. Journal of visualized experiments : JoVE. 2020 Academic Article GET IT
Times cited: 5
Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies. Frontiers in cell and developmental biology. 2019 Academic Article GET IT
Times cited: 57
Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH. Science signaling. 2018 Academic Article GET IT
Times cited: 22
Pharmacological modulation of the CO₂/HCO₃^-/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase. Pharmacology & therapeutics. 2018 Review GET IT
Times cited: 37
Distinct intracellular sAC-cAMP domains regulate ER Ca²⁺ signaling and OXPHOS function. Journal of cell science. 2017 Academic Article GET IT
Times cited: 21
Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2017 Academic Article GET IT
Times cited: 11
Soluble adenylyl cyclase is essential for proper lysosomal acidification. The Journal of general physiology. 2016 Academic Article GET IT
Times cited: 27
Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models. Scientific reports. 2016 Academic Article GET IT
Times cited: 33
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nature chemical biology. 2016 Academic Article GET IT
Times cited: 55
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. Oncotarget. 2016 Academic Article GET IT
Times cited: 15
Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 17
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. The Journal of experimental medicine. 2015 Academic Article GET IT
Times cited: 74
A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice. American journal of respiratory cell and molecular biology. 2014 Academic Article GET IT
Times cited: 25
Physiological roles of acid-base sensors. Annual review of physiology. 2014 Review GET IT
Times cited: 62
The role of soluble adenylyl cyclase in health and disease. Biochimica et biophysica acta. 2014 Editorial Article GET IT
Times cited: 5
Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 20
A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Academic Article GET IT
Times cited: 27
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 94
Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism. Investigative ophthalmology & visual science. 2014 Academic Article GET IT
Times cited: 9
pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC). Frontiers in physiology. 2013 Review GET IT
Times cited: 89
Thiol changes during epididymal maturation: a link to flagellar angulation in mouse spermatozoa?. Andrology. 2013 Academic Article GET IT
Times cited: 23
Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 77
CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 93
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. The Journal of pharmacology and experimental therapeutics. 2013 Academic Article GET IT
Times cited: 73
cAMP and mitochondria. Physiology (Bethesda, Md.). 2013 Review GET IT
Times cited: 126
Neuronal expression of soluble adenylyl cyclase in the mammalian brain. Brain research. 2013 Academic Article GET IT
Times cited: 40
High adenylyl cyclase activity and in vivo cAMP fluctuations in corals suggest central physiological role. Scientific reports. 2013 Academic Article GET IT
Times cited: 17
Identification of a haem domain in human soluble adenylate cyclase. Bioscience reports. 2012 Academic Article GET IT
Times cited: 22
Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Neuron. 2012 Academic Article GET IT
Times cited: 193
Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. PloS one. 2012 Academic Article GET IT
Times cited: 13
Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. PloS one. 2012 Academic Article GET IT
Times cited: 21
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa. Journal of molecular biology. 2011 Academic Article GET IT
Times cited: 28
Role of soluble adenylyl cyclase in the heart. American journal of physiology. Heart and circulatory physiology. 2011 Review GET IT
Times cited: 24
Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 39
Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 38
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 105
The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryotic cell. 2011 Academic Article GET IT
Times cited: 101
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells. The Journal of pharmacology and experimental therapeutics. 2011 Academic Article GET IT
Times cited: 7
Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney international. 2011 Review GET IT
Times cited: 166
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling. Sensors (Basel, Switzerland). 2011 Review GET IT
Times cited: 37
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS pathogens. 2010 Academic Article GET IT
Times cited: 93
Physiological carbon dioxide, bicarbonate, and pH sensing. Pflugers Archiv : European journal of physiology. 2010 Review GET IT
Times cited: 92
Modulation of NaCl absorption by [HCO(3)(-)] in the marine teleost intestine is mediated by soluble adenylyl cyclase. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 Academic Article GET IT
Times cited: 53
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. The Journal of investigative dermatology. 2010 Academic Article GET IT
Times cited: 41
Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 75
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. Cell metabolism. 2009 Academic Article GET IT
Times cited: 378
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 46
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PloS one. 2008 Academic Article GET IT
Times cited: 50
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. The Journal of general physiology. 2008 Academic Article GET IT
Times cited: 95
Structure-based development of novel adenylyl cyclase inhibitors. Journal of medicinal chemistry. 2008 Academic Article GET IT
Times cited: 26
"Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells. Journal of neuroscience research. 2008 Academic Article GET IT
Times cited: 13
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. The Journal of general physiology. 2007 Academic Article GET IT
Times cited: 94
Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. Biochemical and biophysical research communications. 2007 Academic Article GET IT
Times cited: 44
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nature neuroscience. 2006 Academic Article GET IT
Times cited: 88
Molecular details of cAMP generation in mammalian cells: a tale of two systems. Journal of molecular biology. 2006 Review GET IT
Times cited: 256
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 64
Autoinhibitory regulation of soluble adenylyl cyclase. Molecular reproduction and development. 2006 Academic Article GET IT
Times cited: 46
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryotic cell. 2006 Academic Article GET IT
Times cited: 139
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Current biology : CB. 2005 Academic Article GET IT
Times cited: 337
The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Developmental cell. 2005 Academic Article GET IT
Times cited: 328
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 58
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 68
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nature structural & molecular biology. 2004 Academic Article GET IT
Times cited: 138
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Development genes and evolution. 2004 Academic Article GET IT
Times cited: 30
Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. The Journal of cell biology. 2004 Academic Article GET IT
Times cited: 144
Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 200
Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 284
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium. American journal of physiology. Cell physiology. 2003 Academic Article GET IT
Times cited: 36
Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002 Academic Article GET IT
Times cited: 244
Different pathways of cell killing by gossypol enantiomers. Experimental biology and medicine (Maywood, N.J.). 2002 Academic Article GET IT
Times cited: 53
Identification of transmembrane adenylyl cyclase isoforms. Methods in enzymology. 2002 Academic Article GET IT
Times cited: 3
Purification of soluble adenylyl cyclase. Methods in enzymology. 2002 Academic Article GET IT
Times cited: 10
CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor. Trends in endocrinology and metabolism: TEM. 2001 Review GET IT
Times cited: 96
Bicarbonate-regulated soluble adenylyl cyclase. JOP : Journal of the pancreas. 2001 Review GET IT
Times cited: 63
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science (New York, N.Y.). 2000 Academic Article GET IT
Times cited: 691
Specific expression of soluble adenylyl cyclase in male germ cells. Molecular reproduction and development. 2000 Academic Article GET IT
Times cited: 108
A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster. Development genes and evolution. 2000 Academic Article GET IT
Times cited: 27
A calcium-inhibited Drosophila adenylyl cyclase. Biochimica et biophysica acta. 2000 Academic Article GET IT
Times cited: 13
Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Development genes and evolution. 2000 Academic Article GET IT
Times cited: 8
Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 426
Genetic characterization of adenylyl cyclase function. Advances in second messenger and phosphoprotein research. 1998 Review GET IT
Times cited: 8
Cloning and characterization of a Drosophila adenylyl cyclase homologous to mammalian type IX. FEBS letters. 1997 Academic Article GET IT
Times cited: 14
Identification of functional domains of adenylyl cyclase using in vivo chimeras. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 77
CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. The Journal of cell biology. 1994 Academic Article GET IT
Times cited: 148
Preferential expression of the Drosophila rutabaga gene in mushroom bodies, neural centers for learning in insects. Neuron. 1992 Academic Article GET IT
Times cited: 209
Structural basis for the low affinities of yeast cAMP-dependent and mammalian cGMP-dependent protein kinases for protein kinase inhibitor peptides. Biochemistry. 1992 Academic Article GET IT
Times cited: 34
The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase. Cell. 1992 Academic Article GET IT
Times cited: 388
Functional expression of mammalian adenosine cyclic monophosphate-dependent protein kinase in Saccharomyces cerevisiae. Methods in enzymology. 1991 Academic Article GET IT
Times cited: 2
Association of catalytic and regulatory subunits of cyclic AMP-dependent protein kinase requires a negatively charged side group at a conserved threonine. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 50
Purification and characterization of C1, the catalytic subunit of Saccharomyces cerevisiae cAMP-dependent protein kinase encoded by TPK1. The Journal of biological chemistry. 1988 Academic Article GET IT
Times cited: 28
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell. 1988 Academic Article GET IT
Times cited: 195
A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. Science (New York, N.Y.). 1988 Academic Article GET IT
Times cited: 44
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell. 1987 Academic Article GET IT
Times cited: 317

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Research

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Co-investigator Network

Funding awarded

ADCY10 inhibitors as pre-coital, ''on-demand'', non-hormonal male contraceptives awarded by Male Contraceptive Initiative Principal Investigator 2022 - 2024
High Throughput screen to identify "first of their kind" activators of ADCY10 awarded by National Institute on Aging Principal Investigator 2019 - 2023

Microbicide R&D to Advance HIV Prevention Technologies through Responsive Innovation and eXcellence, MATRIX awarded by United States Agency for International Development Co-Investigator 2021 - 2023
Crosstalk Between Metabolic and Signaling Pathways Involved in Sperm Capacitation awarded by National Institute of Child Health & Human Development Co-Investigator 2017 - 2023

Comparative studies on the regulation of metabolism during sperm capacitation awarded by National Institute of Child Health & Human Development Key Personnel 2022 - 2027
Assessing safety of soluble adenylyl cyclase inhibitors validated as lead compounds for on demand male contraceptives. awarded by Male Contraceptive Initiative Key Personnel 2022 - 2024
Discovery and Characterization of an Endogenous Inhibitor of Soluble Adenylyl Cyclase awarded by National Institute of Child Health & Human Development Key Personnel 2021 - 2024
In vivo consequences of on-demand contraception by sAC inhibitors awarded by Male Contraceptive Initiative Key Personnel 2021 - 2023

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Background

education and training

Ph.D., State University of New York at Stony Brook 1989
B.S., Cornell University 1983

Contact

full name

Lonny R. Levin

primary email

llevin@med.cornell.edu

VIVO Weill Cornell Medical College

Lonny R. Levin Professor of Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email