van den Brink, Marcel Rudolf Maria

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Therapeutics Targeting the Gut Microbiome: Rigorous Pipelines for Drug Development. Cell host & microbe. 2020 Comment GET IT
Times cited: 9
Robust CD4+ T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin. Blood advances. 2020 Academic Article GET IT
Times cited: 27
High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis. Nature medicine. 2020 Academic Article GET IT
Times cited: 123
Antibiotic-Induced Shifts in Fecal Microbiota Density and Composition during Hematopoietic Stem Cell Transplantation. Infection and immunity. 2019 Academic Article GET IT
Times cited: 33
Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition. Blood advances. 2019 Academic Article GET IT
Times cited: 37
Diversification and Evolution of Vancomycin-Resistant Enterococcus faecium during Intestinal Domination. Infection and immunity. 2019 Academic Article GET IT
Times cited: 25
Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification. The Journal of experimental medicine. 2018 Academic Article GET IT
Times cited: 103
Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant. Science translational medicine. 2018 Academic Article GET IT
Times cited: 200
Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 75
Integrated DNA/RNA targeted genomic profiling of diffuse large B-cell lymphoma using a clinical assay. Blood cancer journal. 2018 Academic Article GET IT
Times cited: 22
Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT. Blood. 2018 Academic Article GET IT
Times cited: 146
Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice. Cell host & microbe. 2018 Academic Article GET IT
Times cited: 66
The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018 Review GET IT
Times cited: 69
Gut microbiota injury in allogeneic haematopoietic stem cell transplantation. Nature reviews. Cancer. 2018 Review GET IT
Times cited: 144
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Science immunology. 2018 Academic Article GET IT
Times cited: 71
Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury. Nature medicine. 2018 Academic Article GET IT
Times cited: 25
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 182
A Chemotherapy-Only Regimen of Busulfan, Melphalan, and Fludarabine, and Rabbit Antithymocyte Globulin Followed by Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplantations for the Treatment of Myeloid Malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2017 Academic Article GET IT
Times cited: 4
Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease. Blood. 2017 Academic Article GET IT
Times cited: 43
RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Science translational medicine. 2017 Academic Article GET IT
Times cited: 81
Protective Factors in the Intestinal Microbiome Against Clostridium difficile Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation. The Journal of infectious diseases. 2017 Academic Article GET IT
Times cited: 60
Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2017 Academic Article GET IT
Times cited: 203
Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2017 Academic Article GET IT
Times cited: 148
Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant. Leukemia & lymphoma. 2017 Academic Article GET IT
Times cited: 45
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity. Nature medicine. 2017 Academic Article GET IT
Times cited: 154
Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation: Time To T Up the Thymus. Journal of immunology (Baltimore, Md. : 1950). 2017 Review GET IT
Times cited: 59
Ex Vivo CD34⁺-Selected T Cell-Depleted Peripheral Blood Stem Cell Grafts for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia and Myelodysplastic Syndrome Is Associated with Low Incidence of Acute and Chronic Graft-versus-Host Disease and High Treatment Response. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 29
The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease. Blood. 2016 Review GET IT
Times cited: 130
Hematopoietic Cell Transplantation Comorbidity Index Predicts Outcomes in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes Receiving CD34⁺ Selected Grafts for Allogeneic Hematopoietic Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Academic Article GET IT
Times cited: 19
The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Review GET IT
Times cited: 260
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. The Journal of experimental medicine. 2016 Academic Article GET IT
Times cited: 62
Mutational correlates of response to hypomethylating agent therapy in acute myeloid leukemia. Haematologica. 2016 Letter GET IT
Times cited: 27
Antibiotic prophylaxis in allogeneic stem cell transplantation-what is the correct choice?. Bone marrow transplantation. 2016 Comment GET IT
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Science translational medicine. 2016 Academic Article GET IT
Times cited: 337
Thymus: the next (re)generation. Immunological reviews. 2016 Review GET IT
Times cited: 104
Relationship between spontaneous γH2AX foci formation and progenitor functions in circulating hematopoietic stem and progenitor cells among atomic-bomb survivors. Mutation research. Genetic toxicology and environmental mutagenesis. 2016 Academic Article GET IT
Times cited: 3
Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nature immunology. 2016 Academic Article GET IT
Times cited: 422
Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting. Blood. 2016 Academic Article GET IT
Times cited: 208
The European Hematology Association Roadmap for European Hematology Research: a consensus document. Haematologica. 2016 Academic Article GET IT
Times cited: 58
Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2016 Conference Paper GET IT
Times cited: 9
Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses. Cancer research. 2016 Academic Article GET IT
Times cited: 32
Circulating Hematopoietic Stem and Progenitor Cells in Aging Atomic Bomb Survivors. Radiation research. 2015 Academic Article GET IT
Times cited: 6
An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned. International journal of radiation biology. 2015 Academic Article GET IT
Times cited: 18
Role of intestinal microbiota in transplantation outcomes. Best practice & research. Clinical haematology. 2015 Review GET IT
Times cited: 47
High Disease-Free Survival with Enhanced Protection against Relapse after Double-Unit Cord Blood Transplantation When Compared with T Cell-Depleted Unrelated Donor Transplantation in Patients with Acute Leukemia and Chronic Myelogenous Leukemia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 32
Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer. Cancer immunology research. 2015 Academic Article GET IT
Times cited: 30
Sex steroid ablation: an immunoregenerative strategy for immunocompromised patients. Bone marrow transplantation. 2015 Review GET IT
Times cited: 21
Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 464
Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade. Stem cell reports. 2015 Academic Article GET IT
Times cited: 27
Free-hand ultrasound guidance permits safe and efficient minimally invasive intrathymic injections in both young and aged mice. Ultrasound in medicine & biology. 2015 Academic Article GET IT
Times cited: 6
Intensified Mycophenolate Mofetil Dosing and Higher Mycophenolic Acid Trough Levels Reduce Severe Acute Graft-versus-Host Disease after Double-Unit Cord Blood Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Academic Article GET IT
Times cited: 29
Interleukin-22: immunobiology and pathology. Annual review of immunology. 2015 Review GET IT
Times cited: 554
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 209
High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation. Blood. 2014 Academic Article GET IT
Times cited: 86
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature. 2014 Academic Article GET IT
Times cited: 1173
Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 75
Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 201
Overcoming immunological barriers in regenerative medicine. Nature biotechnology. 2014 Academic Article GET IT
Times cited: 100
The role of pattern-recognition receptors in graft-versus-host disease and graft-versus-leukemia after allogeneic stem cell transplantation. Frontiers in immunology. 2014 Review GET IT
Times cited: 81
Histone deacetylation critically determines T cell subset radiosensitivity. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 24
The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood. 2014 Academic Article GET IT
Times cited: 573
Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 5
Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation. PloS one. 2014 Academic Article GET IT
Times cited: 54
WNT signaling suppression in the senescent human thymus. The journals of gerontology. Series A, Biological sciences and medical sciences. 2014 Academic Article GET IT
Times cited: 16
Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy. Blood. 2014 Academic Article GET IT
Times cited: 15
A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity. Cancer discovery. 2014 Academic Article GET IT
Times cited: 44
Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells. PloS one. 2014 Academic Article GET IT
Times cited: 9
Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers. Immunological reviews. 2014 Review GET IT
Times cited: 13
Enhanced responses to tumor immunization following total body irradiation are time-dependent. PloS one. 2013 Academic Article GET IT
Times cited: 11
Clinical applications of palifermin: amelioration of oral mucositis and other potential indications. Journal of cellular and molecular medicine. 2013 Review GET IT
Times cited: 46
Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture. Blood. 2013 Academic Article GET IT
Times cited: 47
Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation. Immunology letters. 2013 Review GET IT
Times cited: 25
PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD. Cancer research. 2013 Academic Article GET IT
Times cited: 8
Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 21
Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 21
Nrf2 regulates haematopoietic stem cell function. Nature cell biology. 2013 Academic Article GET IT
Times cited: 165
Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nature medicine. 2013 Academic Article GET IT
Times cited: 150
Graft-versus-host disease after double-unit cord blood transplantation has unique features and an association with engrafting unit-to-recipient HLA match. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2013 Academic Article GET IT
Times cited: 56
Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization. Infection and immunity. 2013 Academic Article GET IT
Times cited: 316
The central nervous system is a target of acute graft versus host disease in mice. Blood. 2013 Academic Article GET IT
Times cited: 43
Immune tolerance and transplantation. Seminars in oncology. 2012 Review GET IT
Times cited: 52
Extrathymic development of murine T cells after bone marrow transplantation. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 19
Enhancing immune reconstitution: from bench to bedside. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012 Review GET IT
Times cited: 8
Transforming lymph nodes into tissue factories. Nature biotechnology. 2012 Comment GET IT
Times cited: 2
Immune recovery after allogeneic hematopoietic stem cell transplantation: is it time to revisit how patients are monitored?. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012 Academic Article GET IT
Times cited: 5
Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood. 2012 Academic Article GET IT
Times cited: 135
T cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2012 Academic Article GET IT
Times cited: 33
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity. 2012 Academic Article GET IT
Times cited: 444
Palifermin is efficacious in recipients of TBI-based but not chemotherapy-based allogeneic hematopoietic stem cell transplants. Bone marrow transplantation. 2012 Academic Article GET IT
Times cited: 40
Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2012 Academic Article GET IT
Times cited: 638
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 466
Repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer. PloS one. 2012 Academic Article GET IT
Times cited: 5
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. The New England journal of medicine. 2012 Academic Article GET IT
Times cited: 1497
Interleukin-22 drives endogenous thymic regeneration in mice. Science (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 277
Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant. Leukemia & lymphoma. 2012 Academic Article GET IT
Times cited: 35
Supply-side economics finds the thymus. Blood. 2011 Comment GET IT
Times cited: 2
Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation. PloS one. 2011 Academic Article GET IT
Times cited: 3
Greater than the sum of their parts: combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation. Best practice & research. Clinical haematology. 2011 Review GET IT
Times cited: 13
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood. 2011 Academic Article GET IT
Times cited: 58
Serious infection risk and immune recovery after double-unit cord blood transplantation without antithymocyte globulin. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Academic Article GET IT
Times cited: 85
The importance of neovascularization and its inhibition for allogeneic hematopoietic stem cell transplantation. Blood. 2011 Academic Article GET IT
Times cited: 61
Reduced late mortality risk contributes to similar survival after double-unit cord blood transplantation compared with related and unrelated donor hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Academic Article GET IT
Times cited: 66
T cell-depleted unrelated donor stem cell transplantation provides favorable disease-free survival for adults with hematologic malignancies. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2011 Academic Article GET IT
Times cited: 65
Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. The Journal of clinical investigation. 2010 Academic Article GET IT
Times cited: 627
Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2010 Academic Article GET IT
Times cited: 124
Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 21
Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo. Blood. 2010 Academic Article GET IT
Times cited: 34
Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth. Journal of the National Cancer Institute. 2010 Academic Article GET IT
Times cited: 50
MYC as a regulator of ribosome biogenesis and protein synthesis. Nature reviews. Cancer. 2010 Review GET IT
Times cited: 606
Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer. Nature reviews. Cancer. 2010 Review GET IT
Times cited: 202
NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2010 Academic Article GET IT
Times cited: 94
Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients. Blood. 2010 Letter GET IT
Second-line age-adjusted International Prognostic Index in patients with advanced non-Hodgkin lymphoma after T-cell depleted allogeneic hematopoietic SCT. Bone marrow transplantation. 2010 Academic Article GET IT
Times cited: 19
Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors. Blood. 2009 Review GET IT
Times cited: 131
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. The Journal of clinical investigation. 2009 Academic Article GET IT
Times cited: 61
Relapse after allogeneic hematopoietic cell therapy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2009 Review GET IT
Times cited: 87
NOD2 regulates hematopoietic cell function during graft-versus-host disease. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 88
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Academic Article GET IT
Times cited: 20
Rejuvenation of the aging T cell compartment. Current opinion in immunology. 2009 Review GET IT
Times cited: 58
Thymic involution and immune reconstitution. Trends in immunology. 2009 Review GET IT
Times cited: 347
Luteinizing hormone-releasing hormone enhances T cell recovery following allogeneic bone marrow transplantation. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 64
Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man. Seminars in immunopathology. 2008 Review GET IT
Times cited: 12
Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation. Blood. 2008 Academic Article GET IT
Times cited: 24
IL-17 contributes to CD4-mediated graft-versus-host disease. Blood. 2008 Academic Article GET IT
Times cited: 223
STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease. Blood. 2008 Academic Article GET IT
Times cited: 52
Rapidly proliferating CD44hi peripheral T cells undergo apoptosis and delay posttransplantation T-cell reconstitution after allogeneic bone marrow transplantation. Blood. 2008 Academic Article GET IT
Times cited: 14
Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2008 Academic Article GET IT
Times cited: 54
Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nature biotechnology. 2008 Academic Article GET IT
Times cited: 100
Organ-derived dendritic cells have differential effects on alloreactive T cells. Blood. 2008 Academic Article GET IT
Times cited: 28
Clinical strategies to enhance posttransplant immune reconstitution. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2008 Review GET IT
Times cited: 15
The 2008 education supplement on hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2008 Article GET IT
Generation of pro-T cells in vitro: potential for immune reconstitution. Seminars in immunology. 2007 Review GET IT
Times cited: 13
Clinical strategies to enhance T cell reconstitution. Seminars in immunology. 2007 Review GET IT
Times cited: 60
Enhancing T cell reconstitution after hematopoietic stem cell transplantation: a brief update of the latest trends. Blood cells, molecules & diseases. 2007 Review GET IT
Times cited: 18
Fludarabine-based conditioning secures engraftment of second hematopoietic stem cell allografts (HSCT) in the treatment of initial graft failure. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2007 Academic Article GET IT
Times cited: 41
T cell depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin. Blood. 2007 Academic Article GET IT
Times cited: 99
IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 17
Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 15
Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science (New York, N.Y.). 2007 Academic Article GET IT
Times cited: 177
Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity. Blood. 2007 Academic Article GET IT
Times cited: 26
Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation. Journal of molecular medicine (Berlin, Germany). 2007 Review GET IT
Times cited: 4
Preparing for the unthinkable: emergency preparedness for the hematopoietic cell transplant program. 2006 GET IT
Times cited: 3
DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic hemopoietic stem cell transplantation. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 16
Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nature medicine. 2006 Academic Article GET IT
Times cited: 158
Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 153
Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cells. Cell transplantation. 2006 Academic Article GET IT
Times cited: 18
TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Annals of the New York Academy of Sciences. 2005 Academic Article GET IT
Times cited: 182
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood. 2005 Academic Article GET IT
Times cited: 167
Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood. 2005 Academic Article GET IT
Times cited: 91
Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model. Blood. 2005 Academic Article GET IT
Times cited: 12
CCR2 is required for CD8-induced graft-versus-host disease. Blood. 2005 Academic Article GET IT
Times cited: 80
Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation. Blood. 2005 Academic Article GET IT
Times cited: 45
IL-7 and IL-15: therapeutic cytokines for immunodeficiency. Trends in immunology. 2005 Review GET IT
Times cited: 122
Strategies to enhance T-cell reconstitution in immunocompromised patients. Nature reviews. Immunology. 2004 Review GET IT
Times cited: 131
Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation. Blood. 2004 Academic Article GET IT
Times cited: 115
GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease. The Journal of experimental medicine. 2004 Academic Article GET IT
Times cited: 92
Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2004 Academic Article GET IT
Times cited: 8
Kinetics of gene expression in murine cutaneous graft-versus-host disease. The American journal of pathology. 2004 Academic Article GET IT
Times cited: 58
Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice. Experimental hematology. 2004 Academic Article GET IT
Times cited: 49
LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood. 2003 Academic Article GET IT
Times cited: 117
IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. The Journal of clinical investigation. 2003 Academic Article GET IT
Times cited: 155
Insulin-like growth factor-I enhances lymphoid and myeloid reconstitution after allogeneic bone marrow transplantation. Transplantation. 2003 Academic Article GET IT
Times cited: 55
Nature's TRAIL--on a path to cancer immunotherapy. Immunity. 2003 Review GET IT
Times cited: 288
T cells require TRAIL for optimal graft-versus-tumor activity. Nature medicine. 2002 Academic Article GET IT
Times cited: 136
Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation. Blood. 2002 Academic Article GET IT
Times cited: 114
Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations. Blood. 2002 Academic Article GET IT
Times cited: 157
Cytolytic pathways in haematopoietic stem-cell transplantation. Nature reviews. Immunology. 2002 Review GET IT
Times cited: 146
Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood. 2001 Academic Article GET IT
Times cited: 178
Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect. Blood. 2001 Academic Article GET IT
Times cited: 157
Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease. Transplantation. 2000 Academic Article GET IT
Times cited: 22
A phase II pilot trial of concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin 2, and interferon alpha-2B in patients with metastatic melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2000 Academic Article GET IT
Times cited: 83
Graft-versus-host-disease-associated thymic damage results in the appearance of T cell clones with anti-host reactivity. Transplantation. 2000 Academic Article GET IT
Times cited: 67
Fas-deficient lpr mice are more susceptible to graft-versus-host disease. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 59
Requirement for Shc in TCR-mediated activation of a T cell hybridoma. Journal of immunology (Baltimore, Md. : 1950). 1999 Academic Article GET IT
Times cited: 26
IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation. The Journal of clinical investigation. 1999 Academic Article GET IT
Times cited: 154
The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 91
Positive and negative signaling pathways. Transplantation proceedings. 1999 Review GET IT
Times cited: 1
Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood. 1998 Academic Article GET IT
Times cited: 111
AIDS-related Kaposi's sarcoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1997 Academic Article GET IT
Times cited: 3
Characterization of maturation and function of natural killer cells in xenogeneic (rat-->mouse) bone marrow chimeras. Evidence that rat NK cells are present and functional in a xenogeneic environment. Transplantation. 1993 Academic Article GET IT
Times cited: 5
Mixed xenogeneic chimeras (rat + mouse to mouse). Evidence of rat stem cell engraftment, strain-specific transplantation tolerance, and skin-specific antigens. Transplantation. 1992 Academic Article GET IT
Times cited: 41
In situ localization of 3.2.3+ natural killer cells in tissues from normal and tumor-bearing rats. Cancer research. 1991 Academic Article GET IT
Times cited: 36
Cross-species bone marrow transplantation: evidence for tolerance induction, stem cell engraftment, and maturation of T lymphocytes in a xenogeneic stromal environment (rat----mouse). The Journal of experimental medicine. 1991 Academic Article GET IT
Times cited: 69
Effects of in vivo treatment with FK506 on natural killer cells in rats. Transplantation. 1991 Academic Article GET IT
Times cited: 11
Cross-species mixed chimerism (mouse + rat----mouse): facilitated engraftment of rat stem cells with untreated rat bone marrow. Transplantation proceedings. 1991 Academic Article GET IT
Times cited: 2
The generation of natural killer (NK) cells from NK precursor cells in rat long-term bone marrow cultures. The Journal of experimental medicine. 1990 Academic Article GET IT
Times cited: 53
In vivo treatment with monoclonal antibody 3.2.3 selectively eliminates natural killer cells in rats. The Journal of experimental medicine. 1990 Academic Article GET IT
Times cited: 82
Lymphokine-activated killer cells selectively kill tumor cells in bone marrow without compromising bone marrow stem cell function in vitro. Blood. 1989 Academic Article GET IT
Times cited: 30
Lymphokine-activated killer cells in rats: generation of natural killer cells and lymphokine-activated killer cells from bone marrow progenitor cells. Cellular immunology. 1989 Academic Article GET IT
Times cited: 14

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Background

education and training

Ph.D., Leiden University (Netherlands) 1991
M.D., University of Leiden, Faculty of Medicine (Netherlands) 1986
M.S., Leiden University (Netherlands) 1985
B.S., Leiden University (Netherlands) 1982

Contact

full name

Marcel Rudolf Maria van den Brink

primary email

VandenbM@mskcc.org

VIVO Weill Cornell Medical College

Marcel Rudolf Maria van den Brink Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email