MYC as a regulator of ribosome biogenesis and protein synthesis. Review uri icon

Overview

abstract

  • MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.

publication date

  • April 1, 2010

Research

keywords

  • Genes, myc
  • Proto-Oncogene Proteins c-myc
  • Ribosomes

Identity

Scopus Document Identifier

  • 77949920493

Digital Object Identifier (DOI)

  • 10.1038/nrc2819

PubMed ID

  • 20332779

Additional Document Info

volume

  • 10

issue

  • 4