Glickman, Michael S.

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A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 12
Bacterial immunotherapy for cancer induces CD4-dependent tumor-specific immunity through tumor-intrinsic interferon-γ signaling. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 41
Determinants of COVID-19 disease severity in patients with cancer. Nature medicine. 2020 Academic Article GET IT
Times cited: 395
TOX is a critical regulator of tumour-specific T cell differentiation. Nature. 2019 Academic Article GET IT
Times cited: 495
Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed. Scientific reports. 2017 Academic Article GET IT
Times cited: 105
Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA. eLife. 2017 Academic Article GET IT
Times cited: 79
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress. The EMBO journal. 2017 Academic Article GET IT
Times cited: 32
Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleases. Nucleic acids research. 2016 Academic Article GET IT
Times cited: 13
Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase. Nucleic acids research. 2016 Academic Article GET IT
Times cited: 14
Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 32
Control of T cell antigen reactivity via programmed TCR downregulation. Nature immunology. 2016 Academic Article GET IT
Times cited: 56
Clinical and radiographic differentiation of lung nodules caused by mycobacteria and lung cancer: a case-control study. BMC infectious diseases. 2015 Academic Article GET IT
Times cited: 4
RecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of Mycobacteria. Journal of bacteriology. 2015 Academic Article GET IT
Times cited: 13
Genome-Wide Mapping of the Distribution of CarD, RNAP σ^A, and RNAP β on the Mycobacterium smegmatis Chromosome using Chromatin Immunoprecipitation Sequencing. Genomics data. 2014 Academic Article GET IT
Times cited: 13
Double-Strand DNA Break Repair in Mycobacteria. Microbiology spectrum. 2014 Review GET IT
Times cited: 11
Novel imidazoline antimicrobial scaffold that inhibits DNA replication with activity against mycobacteria and drug resistant Gram-positive cocci. ACS chemical biology. 2014 Academic Article GET IT
Times cited: 17
RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 11
An essential nonredundant role for mycobacterial DnaK in native protein folding. PLoS genetics. 2014 Academic Article GET IT
Times cited: 47
DNA ligase C1 mediates the LigD-independent nonhomologous end-joining pathway of Mycobacterium smegmatis. Journal of bacteriology. 2014 Academic Article GET IT
Times cited: 14
Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection. Infection and immunity. 2014 Academic Article GET IT
Times cited: 15
The Rip1 protease of Mycobacterium tuberculosis controls the SigD regulon. Journal of bacteriology. 2014 Academic Article GET IT
Times cited: 17
The mechanism of action of BCG therapy for bladder cancer--a current perspective. Nature reviews. Urology. 2014 Review GET IT
Times cited: 453
Function of site-2 proteases in bacteria and bacterial pathogens. Biochimica et biophysica acta. 2013 Review GET IT
Times cited: 33
Essential yet limited role for CCR2⁺ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming. eLife. 2013 Academic Article GET IT
Times cited: 101
Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 12
M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model. PloS one. 2013 Academic Article GET IT
Times cited: 5
Structure and function of CarD, an essential mycobacterial transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 69
Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells. Cancer research. 2013 Academic Article GET IT
Times cited: 71
A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing. Nucleic acids research. 2013 Academic Article GET IT
Times cited: 25
Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D. Biochemistry. 2012 Academic Article GET IT
Times cited: 22
Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. Journal of bacteriology. 2012 Academic Article GET IT
Times cited: 53
Inhibition of mycobacterial infection by the tumor suppressor PTEN. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 31
Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice. Infection and immunity. 2012 Academic Article GET IT
Times cited: 66
Converting cancer therapies into cures: lessons from infectious diseases. Cell. 2012 Academic Article GET IT
Times cited: 140
Legionella jordanis in hematopoietic SCT patients radiographically mimicking invasive mold infection. 2011 GET IT
Times cited: 15
Catalytic and non-catalytic roles for the mono-ADP-ribosyltransferase Arr in the mycobacterial DNA damage response. PloS one. 2011 Academic Article GET IT
Times cited: 14
A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo. PLoS pathogens. 2011 Academic Article GET IT
Times cited: 158
CarD: a new RNA polymerase modulator in mycobacteria. Transcription. 2011 Review GET IT
Times cited: 12
Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways. Molecular microbiology. 2010 Academic Article GET IT
Times cited: 81
An improved counterselectable marker system for mycobacterial recombination using galK and 2-deoxy-galactose. Gene. 2010 Academic Article GET IT
Times cited: 36
Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence. Microbes and infection. 2010 Review GET IT
Times cited: 47
M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates. Molecular microbiology. 2010 Academic Article GET IT
Times cited: 46
Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates. Journal of bacteriology. 2010 Academic Article GET IT
Times cited: 41
CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell. 2009 Academic Article GET IT
Times cited: 174
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis. Chemistry & biology. 2009 Academic Article GET IT
Times cited: 95
AdnAB: a new DSB-resecting motor-nuclease from mycobacteria. Genes & development. 2009 Academic Article GET IT
Times cited: 68
Mutational analysis of Mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling. Biochemistry. 2009 Academic Article GET IT
Times cited: 28
Use of sloppy molecular beacon probes for identification of mycobacterial species. Journal of clinical microbiology. 2009 Academic Article GET IT
Times cited: 38
Mycobacterium haemophilum infection after alemtuzumab treatment. Emerging infectious diseases. 2008 Letter GET IT
Times cited: 19
Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 152
Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase. Biochemistry. 2008 Academic Article GET IT
Times cited: 42
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes & development. 2008 Academic Article GET IT
Times cited: 94
Bacterial DNA repair by non-homologous end joining. Nature reviews. Microbiology. 2007 Review GET IT
Times cited: 215
Leprosy as immune reconstitution inflammatory syndrome in HIV-positive persons. Emerging infectious diseases. 2007 Letter GET IT
Times cited: 22
Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells. PLoS pathogens. 2007 Academic Article GET IT
Times cited: 241
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks. Journal of bacteriology. 2007 Academic Article GET IT
Times cited: 76
Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 60
Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence. The Journal of clinical investigation. 2006 Academic Article GET IT
Times cited: 160
Site-2 proteases in prokaryotes: regulated intramembrane proteolysis expands to microbial pathogenesis. Microbes and infection. 2006 Review GET IT
Times cited: 45
Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 57
Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 59
Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis. Nature. 2005 Academic Article GET IT
Times cited: 89
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nature structural & molecular biology. 2005 Academic Article GET IT
Times cited: 167
Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 199
Biochemical and genetic analysis of the four DNA ligases of mycobacteria. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 125
Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction. Applied and environmental microbiology. 2003 Academic Article GET IT
Times cited: 15
The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 70
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 166
Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. Cell. 2001 Review GET IT
Times cited: 243
The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 114
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Molecular cell. 2000 Academic Article GET IT
Times cited: 551
Acute epiglottitis due to Pasteurella multocida in an adult without animal exposure. Emerging infectious diseases. 1997 Letter GET IT
Times cited: 19
Antibody-catalyzed degradation of cocaine. Science (New York, N.Y.). 1993 Academic Article GET IT
Times cited: 248

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Research

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Funding awarded

Determinants of TB control, relapse and reinfection awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2021 - 2026

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Background

education and training

M.D., Columbia University College of Physicians and Surgeons 1993
B.A., Dartmouth College 1989

Contact

full name

Michael S. Glickman

primary email

glickmam@mskcc.org

VIVO Weill Cornell Medical College

Michael S. Glickman Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email