Site-2 proteases in prokaryotes: regulated intramembrane proteolysis expands to microbial pathogenesis. Review uri icon

Overview

abstract

  • Regulated intramembrane proteolysis (RIP) is a widely distributed mechanism of signal transduction in which membrane-bound proteases cleave transmembrane domains of substrate proteins. The site-2 protease (S2P) class of RIP metalloproteases is present in most bacterial genomes but is generally of unknown function except for the well-characterized proteases RseP and SpoIVFB. In this review we will discuss the biochemical functions and physiologic roles of S2P proteases in bacteria and highlight recent data implicating S2P family members in host-pathogen interactions.

publication date

  • April 27, 2006

Research

keywords

  • Bacteria
  • Bacterial Proteins
  • Endopeptidases
  • Membrane Proteins
  • Virulence Factors

Identity

Scopus Document Identifier

  • 33746411866

Digital Object Identifier (DOI)

  • 10.1016/j.micinf.2006.02.021

PubMed ID

  • 16731018

Additional Document Info

volume

  • 8

issue

  • 7