Hegde, Muralidhar

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selected publications

Polyphenols as Potential Metal Chelation Compounds Against Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2021 Review GET IT
Times cited: 40
Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective. Cells. 2020 Review GET IT
Times cited: 35
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges. Progress in neurobiology. 2019 Review GET IT
Times cited: 22
Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis. International journal of molecular sciences. 2019 Review GET IT
Times cited: 39
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. Molecular nutrition & food research. 2018 Academic Article GET IT
Times cited: 40
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress. DNA repair. 2018 Academic Article GET IT
Times cited: 16
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1. Journal of Alzheimer's disease : JAD. 2018 Academic Article GET IT
Times cited: 7
Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis. Oncotarget. 2017 Academic Article GET IT
Times cited: 9
Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase. Genes. 2017 Academic Article GET IT
Times cited: 42
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex. Nucleic acids research. 2017 Academic Article GET IT
Times cited: 60
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity. Molecular and cellular biology. 2017 Academic Article GET IT
Times cited: 34
An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?. Journal of Alzheimer's disease : JAD. 2017 Review GET IT
Times cited: 9
Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease. Journal of Alzheimer's disease : JAD. 2017 Academic Article GET IT
Times cited: 52
DNA damage responses in central nervous system and age-associated neurodegeneration. Mechanisms of ageing and development. 2017 Editorial Article GET IT
Times cited: 8
Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A. Nucleic acids research. 2016 Academic Article GET IT
Times cited: 11
Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 123
TDP-43/FUS in motor neuron disease: Complexity and challenges. Progress in neurobiology. 2016 Review GET IT
Times cited: 72
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?. Mechanisms of ageing and development. 2016 Review GET IT
Times cited: 22
Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget. 2016 Academic Article GET IT
Times cited: 11
8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging. Mechanisms of ageing and development. 2016 Academic Article GET IT
Times cited: 11
Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling. Free radical biology & medicine. 2015 Academic Article GET IT
Times cited: 27
The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD. The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 36
The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis. PLoS genetics. 2015 Academic Article GET IT
Times cited: 69
New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins. Cellular and molecular life sciences : CMLS. 2015 Review GET IT
Times cited: 39
The role of 8-oxoguanine DNA glycosylase-1 in inflammation. International journal of molecular sciences. 2014 Review GET IT
Times cited: 80
New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases. Biomolecules. 2014 Review GET IT
Times cited: 27
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice. Cell reports. 2014 Academic Article GET IT
Times cited: 53
Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases. Journal of pharmacy & bioallied sciences. 2014 Academic Article GET IT
8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization. Free radical biology & medicine. 2014 Academic Article GET IT
Times cited: 48
Identification and characterization of a basic thaumatin-like protein (TLP 2) as an allergen in sapodilla plum (Manilkara zapota). Molecular nutrition & food research. 2013 Academic Article GET IT
Times cited: 10
Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 76
Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair. DNA repair. 2013 Academic Article GET IT
Times cited: 56
8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1. Free radical biology & medicine. 2013 Academic Article GET IT
Times cited: 71
The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions. Journal of molecular biology. 2013 Academic Article GET IT
Times cited: 39
Human DNA Glycosylase NEIL1's Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival. Biomolecules. 2012 Academic Article GET IT
Times cited: 81
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 24
Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease. Molecular neurobiology. 2012 Review GET IT
Times cited: 80
Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 44
Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 105
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. DNA repair. 2012 Academic Article GET IT
Times cited: 35
New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders. Journal of pharmacy & bioallied sciences. 2012 Academic Article GET IT
Times cited: 39
Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mechanisms of ageing and development. 2012 Review GET IT
Times cited: 107
Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes. Progress in molecular biology and translational science. 2012 Review GET IT
Times cited: 60
Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 75
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. Cell research. 2011 Academic Article GET IT
Times cited: 28
Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword. Journal of Alzheimer's disease : JAD. 2011 Review GET IT
Times cited: 53
Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 115
Functions of disordered regions in mammalian early base excision repair proteins. Cellular and molecular life sciences : CMLS. 2010 Review GET IT
Times cited: 57
Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 57
Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar Depression. Indian journal of psychiatry. 2010 Academic Article GET IT
Times cited: 21
RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures. DNA repair. 2010 Academic Article GET IT
Times cited: 47
Challenges associated with metal chelation therapy in Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2009 Review GET IT
Times cited: 131
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 85
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell research. 2008 Review GET IT
Times cited: 483
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 129
Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways. Journal of molecular biology. 2007 Academic Article GET IT
Times cited: 26
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 98
DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes. Archives of biochemistry and biophysics. 2007 Academic Article GET IT
Times cited: 64
A new evidence for DNA nicking property of amyloid beta-peptide (1-42): relevance to Alzheimer's disease. Archives of biochemistry and biophysics. 2007 Academic Article GET IT
Times cited: 27
Role of protein conformational dynamics and DNA integrity in relevance to neuronal cell death in neurodegeneration. Current Alzheimer research. 2006 Review GET IT
Times cited: 19
Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference. Progress in neurobiology. 2006 Review GET IT
Times cited: 41
Studies on genomic DNA topology and stability in brain regions of Parkinson's disease. Archives of biochemistry and biophysics. 2006 Academic Article GET IT
Times cited: 55
An algorithmic approach to understand trace elemental homeostasis in serum samples of Parkinson disease. Computers in biology and medicine. 2005 Academic Article GET IT
Times cited: 10
Aluminium in Alzheimer's disease: are we still at a crossroad?. Cellular and molecular life sciences : CMLS. 2005 Review GET IT
Times cited: 274
First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease. Journal of molecular neuroscience : MN. 2004 Academic Article GET IT
Times cited: 70
Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2004 Academic Article GET IT
Times cited: 119
Challenges and complexities of alpha-synuclein toxicity: new postulates in unfolding the mystery associated with Parkinson's disease. Archives of biochemistry and biophysics. 2003 Review GET IT
Times cited: 34

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Background

education and training

Ph.D., Mysore University (India) 2006
M.S., Karnataka University (India) 2000
B.S., Karnataka University (India) 1998

Contact

full name

Muralidhar Hegde

primary email

mlh2004@med.cornell.edu

VIVO Weill Cornell Medical College

Muralidhar Hegde Assistant Professor of Neuroscience in Neurological Surgery

Publications

selected publications

Background

education and training

Contact

full name

primary email