Wilson, Patrick

Publications

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Co-Author Network

selected publications

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants. The Journal of clinical investigation. 2023 Academic Article GET IT
Times cited: 2
A hybrid single cell demultiplexing strategy that increases both cell recovery rate and calling accuracy. bioRxiv : the preprint server for biology. 2023 Article GET IT
Fate-mapping antibodies to study sinful immune dynamics. Nature immunology. 2023 Comment GET IT
Learning from our differences. Nature immunology. 2022 Academic Article GET IT
Memory B cell diversity: insights for optimized vaccine design. Trends in immunology. 2022 Review GET IT
Times cited: 6
Librator: a platform for the optimized analysis, design, and expression of mutable influenza viral antigens. Briefings in bioinformatics. 2022 Academic Article GET IT
Times cited: 1
Teach 'em young: Influenza vaccines induce broadly neutralizing antibodies in children. Cell reports. Medicine. 2022 Comment GET IT
Broadly neutralizing antibodies target a haemagglutinin anchor epitope. Nature. 2021 Academic Article GET IT
Times cited: 28
Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease. Nature microbiology. 2021 Academic Article GET IT
Times cited: 44
SARS-CoV-2 infection induces cross-reactive autoantibodies against angiotensin II. medRxiv : the preprint server for health sciences. 2021 Article GET IT
Times cited: 1452
Bridging the B Cell Gap: Novel Technologies to Study Antigen-Specific Human B Cell Responses. Vaccines. 2021 Review GET IT
Times cited: 397
An Egg-Derived Sulfated N-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines. mBio. 2021 Academic Article GET IT
Times cited: 5
Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 8
First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes. Science translational medicine. 2021 Academic Article GET IT
Times cited: 17
B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat. Viruses. 2021 Review GET IT
Times cited: 20
Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets. Immunity. 2021 Academic Article GET IT
Times cited: 54
Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 6
Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase. mSphere. 2021 Academic Article GET IT
Times cited: 8
Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. PLoS pathogens. 2021 Academic Article GET IT
Times cited: 6
SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike. mBio. 2021 Academic Article GET IT
Times cited: 51
Remembering seasonal coronaviruses. Science (New York, N.Y.). 2020 Comment GET IT
Times cited: 20
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans. Science translational medicine. 2020 Academic Article GET IT
Times cited: 46
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial. Nature medicine. 2020 Academic Article GET IT
Times cited: 131
Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation. Frontiers in immunology. 2020 Academic Article GET IT
Times cited: 1
Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops. eLife. 2020 Academic Article GET IT
Times cited: 12
Proinflammatory IgG Fc structures in patients with severe COVID-19. medRxiv : the preprint server for health sciences. 2020 Article GET IT
Characterization of Novel Cross-Reactive Influenza B Virus Hemagglutinin Head Specific Antibodies That Lack Hemagglutination Inhibition Activity. Journal of virology. 2020 Academic Article GET IT
Times cited: 3
Proinflammatory IgG Fc structures in patients with severe COVID-19. Nature immunology. 2020 Academic Article GET IT
Times cited: 161
Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses. Immunity. 2020 Academic Article GET IT
Times cited: 43
Correctly folded - but not necessarily functional - influenza virus neuraminidase is required to induce protective antibody responses in mice. Vaccine. 2020 Academic Article GET IT
Times cited: 13
SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike. bioRxiv : the preprint server for biology. 2020 Article GET IT
Times cited: 406
Imprinting, immunodominance, and other impediments to generating broad influenza immunity. Immunological reviews. 2020 Review GET IT
Times cited: 26
Characterizing Emerging Canine H3 Influenza Viruses. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 19
High-complexity extracellular barcoding using a viral hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 1
It's Hard to Teach an Old B Cell New Tricks. Cell. 2020 Comment GET IT
Times cited: 2
Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans. Cell reports. 2019 Academic Article GET IT
Times cited: 12
Emerging from the Shadow of Hemagglutinin: Neuraminidase Is an Important Target for Influenza Vaccination. Cell host & microbe. 2019 Comment GET IT
Times cited: 10
Aging and influenza vaccine-induced immunity. Cellular immunology. 2019 Review GET IT
Times cited: 55
Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial. The Lancet. Infectious diseases. 2019 Academic Article GET IT
Times cited: 84
Monoclonal Antibody Responses after Recombinant Hemagglutinin Vaccine versus Subunit Inactivated Influenza Virus Vaccine: a Comparative Study. Journal of virology. 2019 Academic Article GET IT
Times cited: 14
Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. Cell. 2019 Academic Article GET IT
Times cited: 287
Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin. eLife. 2019 Academic Article GET IT
Times cited: 42
The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain. Nature microbiology. 2019 Academic Article GET IT
Times cited: 36
Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery. Journal of immunology (Baltimore, Md. : 1950). 2019 Academic Article GET IT
Times cited: 18
Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell host & microbe. 2019 Academic Article GET IT
Times cited: 76
Hemagglutinin Stalk-Reactive Antibodies Interfere with Influenza Virus Neuraminidase Activity by Steric Hindrance. Journal of virology. 2019 Academic Article GET IT
Times cited: 34
An Efficient Method to Generate Monoclonal Antibodies from Human B Cells. Methods in molecular biology (Clifton, N.J.). 2019 Academic Article GET IT
Times cited: 23
Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 27
Editorial overview: Tough targets. Current opinion in immunology. 2018 Editorial Article GET IT
Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge. Journal of virology. 2018 Academic Article GET IT
Times cited: 21
Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza. Analytical chemistry. 2018 Academic Article GET IT
Times cited: 16
The influenza virus hemagglutinin head evolves faster than the stalk domain. Scientific reports. 2018 Academic Article GET IT
Times cited: 118
Characterization of the immunologic repertoire: A quick start guide. Immunological reviews. 2018 Article GET IT
Harnessing immune history to combat influenza viruses. Current opinion in immunology. 2018 Review GET IT
Times cited: 43
What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?. Cold Spring Harbor perspectives in biology. 2018 Review GET IT
Times cited: 7
Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies. Cell. 2018 Academic Article GET IT
Times cited: 233
NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?. mBio. 2018 Review GET IT
Times cited: 149
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 350
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nature communications. 2017 Academic Article GET IT
Times cited: 105
Natural polyreactive IgA antibodies coat the intestinal microbiota. Science (New York, N.Y.). 2017 Academic Article GET IT
Times cited: 252
Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo. Scientific reports. 2017 Academic Article GET IT
Times cited: 26
From Original Antigenic Sin to the Universal Influenza Virus Vaccine. Trends in immunology. 2017 Review GET IT
Times cited: 145
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies. Journal of visualized experiments : JoVE. 2017 Academic Article GET IT
Times cited: 5
BASIC: BCR assembly from single cells. Bioinformatics (Oxford, England). 2017 Academic Article GET IT
Times cited: 55
Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation. Science immunology. 2017 Academic Article GET IT
Times cited: 145
Single-Cell Genomics: Approaches and Utility in Immunology. Trends in immunology. 2017 Review GET IT
Times cited: 47
Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nature medicine. 2016 Academic Article GET IT
Times cited: 203
Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients. Acta neuropathologica. 2016 Academic Article GET IT
Times cited: 19
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 128
Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. PLoS pathogens. 2016 Article GET IT
Times cited: 88
Refined protocol for generating monoclonal antibodies from single human and murine B cells. Journal of immunological methods. 2016 Academic Article GET IT
Times cited: 46
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. PLoS pathogens. 2016 Academic Article GET IT
Times cited: 88
To B or not to B maintained?. Blood. 2016 Comment GET IT
Times cited: 1
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 423
Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection. Cell host & microbe. 2016 Academic Article GET IT
Times cited: 199
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?. Current opinion in immunology. 2016 Review GET IT
Times cited: 67
B Cell Responses during Secondary Dengue Virus Infection Are Dominated by Highly Cross-Reactive, Memory-Derived Plasmablasts. Journal of virology. 2016 Academic Article GET IT
Times cited: 88
Taking the Broad View on B Cell Affinity Maturation. Immunity. 2016 Comment GET IT
Times cited: 5
Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 285
Immune history profoundly affects broadly protective B cell responses to influenza. Science translational medicine. 2015 Academic Article GET IT
Times cited: 270
Germinal center selection and the antibody response to influenza. Cell. 2015 Review GET IT
Times cited: 67
Restricted, canonical, stereotyped and convergent immunoglobulin responses. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2015 Review GET IT
Times cited: 35
Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A. Immunity. 2015 Academic Article GET IT
Times cited: 351
High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination. PloS one. 2015 Academic Article GET IT
Times cited: 27
Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. The Journal of clinical investigation. 2015 Academic Article GET IT
Times cited: 104
High preexisting serological antibody levels correlate with diversification of the influenza vaccine response. Journal of virology. 2015 Academic Article GET IT
Times cited: 91
Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients. Diabetes. 2014 Academic Article GET IT
Times cited: 59
Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis. Arthritis & rheumatology (Hoboken, N.J.). 2014 Academic Article GET IT
Times cited: 69
Corrigendum: Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nature protocols. 2014 Article GET IT
Times cited: 1
Staphylococcus aureus infection induces protein A-mediated immune evasion in humans. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 104
Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 158
Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 169
Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes. PLoS pathogens. 2014 Academic Article GET IT
Times cited: 7
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells. Nature communications. 2014 Academic Article GET IT
Times cited: 41
Impact of immunosuppression on recall immune responses to influenza vaccination in stable renal transplant recipients. Transplantation. 2014 Academic Article GET IT
Times cited: 30
Divergent H7 immunogens offer protection from H7N9 virus challenge. Journal of virology. 2014 Academic Article GET IT
Times cited: 48
Immune history shapes specificity of pandemic H1N1 influenza antibody responses. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 132
In vitro assessment of the immunological significance of a human monoclonal antibody directed to the influenza a virus nucleoprotein. Clinical and vaccine immunology : CVI. 2013 Academic Article GET IT
Times cited: 33
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 59
Cross-reactive humoral responses to influenza and their implications for a universal vaccine. Annals of the New York Academy of Sciences. 2013 Review GET IT
Times cited: 26
Lineage structure of the human antibody repertoire in response to influenza vaccination. Science translational medicine. 2013 Academic Article GET IT
Times cited: 259
High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nature biotechnology. 2013 Academic Article GET IT
Times cited: 328
Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 17
Tools to therapeutically harness the human antibody response. Nature reviews. Immunology. 2012 Review GET IT
Times cited: 100
Fully human monoclonal antibodies from antibody secreting cells after vaccination with Pneumovax®23 are serotype specific and facilitate opsonophagocytosis. Immunobiology. 2012 Academic Article GET IT
Times cited: 23
Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses. PloS one. 2012 Academic Article GET IT
Times cited: 75
Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice. mBio. 2012 Academic Article GET IT
Times cited: 62
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 331
Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization. 2012 GET IT
Times cited: 21
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nature medicine. 2012 Academic Article GET IT
Times cited: 163
Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. Journal of virology. 2012 Academic Article GET IT
Times cited: 181
Exploiting human memory B cell heterogeneity for improved vaccine efficacy. Frontiers in immunology. 2011 Academic Article GET IT
Times cited: 22
Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies. Journal of virology. 2011 Academic Article GET IT
Times cited: 84
Targeting B cell responses in universal influenza vaccine design. Trends in immunology. 2011 Review GET IT
Times cited: 46
Harnessing the immune system's arsenal: producing human monoclonal antibodies for therapeutics and investigating immune responses. F1000 biology reports. 2011 Academic Article GET IT
Times cited: 291
Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 226
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. The Journal of experimental medicine. 2011 Academic Article GET IT
Times cited: 652
Rapid generation of rotavirus-specific human monoclonal antibodies from small-intestinal mucosa. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 76
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 2010 Academic Article GET IT
Times cited: 336
The anergic B cell. Blood. 2010 Comment GET IT
Times cited: 23
Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nature protocols. 2009 Academic Article GET IT
Times cited: 357
Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 176
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature. 2008 Academic Article GET IT
Times cited: 802
Human B cell subsets. Advances in immunology. 2008 Review GET IT
Times cited: 63
Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 46
Mature B cells class switched to IgD are autoreactive in healthy individuals. The Journal of clinical investigation. 2007 Academic Article GET IT
Times cited: 106
Igkappa allelic inclusion is a consequence of receptor editing. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 63
Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 55
Programmed cell death of peripheral blood B cells determined by laser scanning cytometry in Sjögren's syndrome with a special emphasis on BAFF. Journal of clinical immunology. 2004 Academic Article GET IT
Times cited: 37
Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells. The Journal of clinical investigation. 2004 Academic Article GET IT
Times cited: 78
Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 109
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature. 2001 Academic Article GET IT
Times cited: 436
Amino acid insertions and deletions contribute to diversify the human Ig repertoire. Immunological reviews. 1998 Review GET IT
Times cited: 36

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Research

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Co-investigator Network

Funding awarded

Turning influenza into measles via MOsaic Natural awarded by Bill & Melinda Gates Foundation Principal Investigator 2021 - 2023

A deep longitudinal analysis of next generation influenza vaccines in older adults. awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2022 - 2026

Center for Lupus Research awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Key Personnel 2022 - 2027

NIAID Centers of Excellence for Influenza Research and Response (CEIRR) awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2021 - 2028
DIVINCI: Dissection of Influenza Vaccination and Infection for Childhood Immunity awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2021 - 2026
PanCoVac - Pan-coronavirus Vaccine Consortium awarded by American Society of Transplatation Principal Investigator Subaward 2021 - 2024
CRUIVV - Center for Research on Universal Influenza Virus Vaccines (Option 3) awarded by National Cancer Institute Principal Investigator Subaward 2022 - 2023
Toward a Universal Influenza Virus Vaccine awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2021 - 2023
CRUIVV - Center for Research on Universal Influenza Virus Vaccines (Option 17A) awarded by National Cancer Institute Principal Investigator Subaward 2021 - 2023
CRUIVV - Center for Research on Universal Influenza Virus Vaccines (Option 17C) awarded by National Cancer Institute Principal Investigator Subaward 2021 - 2023
CRUIVV - Center for Research on Universal Influenza Virus Vaccines (Option 2) awarded by National Cancer Institute Principal Investigator Subaward 2021 - 2022

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Background

education and training

Ph.D., University of Texas Southwestern Medical Center Graduate School of Biomedical Sciences 2000
M.S., Youngstown State University 1994
B.S., Youngstown State University 1992

VIVO Weill Cornell Medical College

Patrick Wilson Professor of Pediatrics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email