Taking the Broad View on B Cell Affinity Maturation. uri icon

Overview

abstract

  • Germinal center (GC) responses are required for the generation of high-affinity antigen-specific B cells. Kuraoka et al. (2016) explore the importance of inter-clonal competition in GC affinity maturation through the use of complex immunizing antigens and discover an unexpected increase in clonal diversity over the course of the response.

publication date

  • March 15, 2016

Research

keywords

  • B-Lymphocytes
  • Clonal Selection, Antigen-Mediated
  • Germinal Center
  • Receptors, Antigen, B-Cell

Identity

Scopus Document Identifier

  • 84960343564

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2016.03.001

PubMed ID

  • 26982359

Additional Document Info

volume

  • 44

issue

  • 3