Longman, Randy

Publications

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selected publications

Increased Primary Bile Acids with Ileocolonic Resection Impact Ileal Inflammation and Gut Microbiota in Inflammatory Bowel Disease. Journal of Crohn's & colitis. 2023 Academic Article GET IT
The Impact of Confounders on Symptom-Endoscopic Discordances in Crohn's Disease. Crohn's & colitis 360. 2023 Academic Article GET IT
Acute high-fat diet impairs macrophage-supported intestinal damage resolution. JCI insight. 2023 Academic Article GET IT
Utility of Therapeutic Drug Monitoring for Tumor Necrosis Factor Antagonists and Ustekinumab in Postoperative Crohn's Disease. Inflammatory bowel diseases. 2022 Academic Article GET IT
Inflammatory Bowel Disease-Associated Gut Commensals Degrade Components of the Extracellular Matrix. mBio. 2022 Academic Article GET IT
Times cited: 1
Serum Ustekinumab Concentrations Are Associated With Improved Outcomes With the Magnetic Resonance Index of Activity for Crohn's Disease. Inflammatory bowel diseases. 2022 Academic Article GET IT
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103⁺ dendritic cell IL-23-dependent ileocolitis. Cell reports. 2022 Academic Article GET IT
Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease. World journal of gastroenterology. 2022 Academic Article GET IT
Times cited: 4
A metagenomic DNA sequencing assay that is robust against environmental DNA contamination. Nature communications. 2022 Academic Article GET IT
Times cited: 5
Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses. Immunity. 2022 Academic Article GET IT
Times cited: 7
Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn's disease. JCI insight. 2022 Academic Article GET IT
Times cited: 6
Human gut bacteria produce Τ_Η17-modulating bile acid metabolites. Nature. 2022 Academic Article GET IT
Times cited: 96
Eating for Two: Diet and the Microbiome in Ulcerative Colitis. Journal of Crohn's & colitis. 2022 Editorial Article GET IT
Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis. Inflammatory bowel diseases. 2022 Academic Article GET IT
Times cited: 8
A Quality Improvement Initiative Is Associated With Reduced Time to Administer Biologics and Small Molecules and Emergency Room Visits in Inflammatory Bowel Disease. Journal of clinical gastroenterology. 2022 Academic Article GET IT
Times cited: 3
Joint Disease Activity in Inflammatory Bowel Disease-associated Peripheral Spondyloarthritis Stratifies Therapeutic Response. Gastro hep advances. 2022 Academic Article GET IT
Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. Cell. 2022 Academic Article GET IT
Times cited: 27
Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer. Gut microbes. 2022 Academic Article GET IT
Times cited: 4
Impact of Inflammatory Bowel Disease Therapies on Durability of Humoral Response to SARS-CoV-2 Vaccination. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2021 Letter GET IT
Times cited: 9
A metagenomic DNA sequencing assay that is robust against environmental DNA contamination. bioRxiv : the preprint server for biology. 2021 Article GET IT
Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease. Nature microbiology. 2021 Academic Article GET IT
Times cited: 44
Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation. Gastroenterology. 2021 Academic Article GET IT
Times cited: 27
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell stem cell. 2021 Academic Article GET IT
Times cited: 9
No Durable Impact of COVID-19 on Intestinal Disease Activity in Subjects With IBD. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2021 Academic Article GET IT
Times cited: 7
Thymic development of gut-microbiota-specific T cells. Nature. 2021 Academic Article GET IT
Times cited: 66
Decoding the matrix: multiomics reveals host-microbe biomarker for inflammatory bowel disease. The Journal of clinical investigation. 2021 Comment GET IT
Times cited: 1
Dual Biologic or Small Molecule Therapy for Treatment of Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2021 Review GET IT
Times cited: 44
Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation. Cell host & microbe. 2021 Academic Article GET IT
Times cited: 36
Utility of magnetic resonance imaging in Crohn's associated sacroiliitis: A cross-sectional study. International journal of rheumatic diseases. 2021 Academic Article GET IT
Times cited: 1
A Diamond in the Rough: IgA-Seq Signatures Stratify New Onset IBD. Cell host & microbe. 2021 Comment GET IT
Times cited: 3
Patient-Preferences Favoring Treatment Discontinuation Are Reduced With Vedolizumab and Ustekinumab Compared With TNF Antagonists in Inflammatory Bowel Disease. Crohn's & colitis 360. 2020 Academic Article GET IT
Baseline Disease Activity and Steroid Therapy Stratify Risk of COVID-19 in Patients With Inflammatory Bowel Disease. Gastroenterology. 2020 Academic Article GET IT
Times cited: 84
Defining the phenotype, pathogenesis and treatment of Crohn's disease associated spondyloarthritis. Journal of gastroenterology. 2020 Review GET IT
Times cited: 4
Author Correction: Bile acid metabolites control T_H17 and T_reg cell differentiation. Nature. 2020 Academic Article GET IT
Times cited: 14
Evaluation of a novel ultraviolet C irradiation locker for microbial sterilization of hospital laboratory coats. The Journal of hospital infection. 2020 Letter GET IT
Times cited: 1
Bile acid metabolites control T_H17 and T_reg cell differentiation. Nature. 2019 Academic Article GET IT
Times cited: 476
Innate lymphoid cells link gut microbes with mucosal T cell immunity. Gut microbes. 2019 Review GET IT
Times cited: 14
The balance of power: innate lymphoid cells in tissue inflammation and repair. The Journal of clinical investigation. 2019 Review GET IT
Times cited: 33
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell host & microbe. 2019 Academic Article GET IT
Times cited: 255
Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis. Immunity. 2018 Academic Article GET IT
Times cited: 83
Critical Role for the Microbiota in CX₃CR1⁺ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity. 2018 Academic Article GET IT
Times cited: 119
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017 Academic Article GET IT
Times cited: 378
Regulation of inflammation by microbiota interactions with the host. Nature immunology. 2017 Review GET IT
Times cited: 380
Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis. Inflammatory bowel diseases. 2017 Academic Article GET IT
Times cited: 79
IgA-coated E. coli enriched in Crohn's disease spondyloarthritis promote T_H17-dependent inflammation. Science translational medicine. 2017 Academic Article GET IT
Times cited: 204
Crohn's Disease: Evolution, Epigenetics, and the Emerging Role of Microbiome-Targeted Therapies. Current gastroenterology reports. 2016 Review GET IT
Times cited: 13
Vedolizumab and Infliximab Combination Therapy in the Treatment of Crohn's Disease. The American journal of gastroenterology. 2015 Letter GET IT
Times cited: 38
The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity. Current opinion in rheumatology. 2015 Review GET IT
Times cited: 54
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Nature biotechnology. 2015 Academic Article GET IT
Times cited: 25
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 274
Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity. Cold Spring Harbor symposia on quantitative biology. 2014 Review GET IT
Times cited: 35
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife. 2013 Academic Article GET IT
Times cited: 1131
Microbial manipulation as primary therapy for Crohn's disease. World journal of gastroenterology. 2013 Academic Article GET IT
Times cited: 4
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature. 2013 Academic Article GET IT
Times cited: 345
A rare intestinal infection with systemic effects. 2012 GET IT
Esophagitis dissecans superficialis. 2011 GET IT
Times cited: 18
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 104
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood. 2006 Academic Article GET IT
Times cited: 52
Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 111
Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C. The Journal of infectious diseases. 2005 Academic Article GET IT
Times cited: 112
A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation. Blood. 2005 Academic Article GET IT
Times cited: 348
Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood. 2003 Academic Article GET IT
Times cited: 134
Methanococcus jannaschii prolyl-cysteinyl-tRNA synthetase possesses overlapping amino acid binding sites. Biochemistry. 2001 Academic Article GET IT
Times cited: 22
One polypeptide with two aminoacyl-tRNA synthetase activities. Science (New York, N.Y.). 2000 Academic Article GET IT
Times cited: 64

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Research

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Funding awarded

Molecular and clinical characterization of IBD patients naive or refractory to standard of care over time awarded by Boehringer Ingelheim Pharmaceuticals, Inc. (Germany) Principal Investigator 2023 - 2024
Multidisciplinary Research Training in Gastroenterology and Hepatology awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2022 - 2024
A randomized, placebo-controlled clinical trial examining the efficacy of Fecal Microbiota Transplantation (FMT) and subsequent dietary fiber in patients with moderate ulcerative colitis (MINDFUL) awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2021 - 2024
TL1A Regulation of Group 3 Innate Lymphoid Cells in Colitis awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2020 - 2024
Multidisciplinary Research Training in Gastroenterology and Hepatology awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2019 - 2024

Tumor selective inhibition of the WNT pathway awarded by National Cancer Institute Co-Investigator 2022 - 2027
Screening for Resistant Enteric Bacteria to Personalize Infection Prevention Strategies in Neutropenic Patients awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2020 - 2024

Targeting the mycobiome in patients with Crohn’s Disease awarded by The Leona M. and Harry B. Helmsley Charitable Trust Key Personnel 2023 - 2025

Anti-phage antibodies in stratifying Crohn''s disease diagnosis and treatment response awarded by Leona M. and Harry B. Helmsley Charitable Trust, The Principal Investigator Subaward 2019 - 2023

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Background

education and training

M.D., Weill Cornell Medical College, Cornell University 2007
Ph.D., The Rockefeller University 2006
B.S., M.S., Yale University 2000

Contact

full name

Randy Longman

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Randy Longman Associate Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

webpage