Darnell, Robert B.

Publications

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selected publications

AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke. Cell reports. 2019 Academic Article GET IT
Times cited: 13
Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation. Nature communications. 2018 Academic Article GET IT
Times cited: 197
Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition. Cell. 2017 Academic Article GET IT
Times cited: 77
Hepatitis C virus RNA functionally sequesters miR-122. Cell. 2015 Academic Article GET IT
Times cited: 256
T cells targeting a neuronal paraneoplastic antigen mediate tumor rejection and trigger CNS autoimmunity with humoral activation. European journal of immunology. 2014 Academic Article GET IT
Times cited: 24
HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell reports. 2014 Academic Article GET IT
Times cited: 235
Turkey must end violent response to protests. Science (New York, N.Y.). 2013 Letter GET IT
Times cited: 1
Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice. Human molecular genetics. 2013 Academic Article GET IT
Times cited: 45
Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo. eLife. 2013 Academic Article GET IT
Times cited: 19
Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Molecular cell. 2012 Academic Article GET IT
Times cited: 257
Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron. 2012 Academic Article GET IT
Times cited: 141
Cellular immune suppression in paraneoplastic neurologic syndromes targeting intracellular antigens. Archives of neurology. 2012 Academic Article GET IT
Times cited: 34
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell. 2011 Academic Article GET IT
Times cited: 1463
Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1. Structure (London, England : 1993). 2011 Academic Article GET IT
Times cited: 46
Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer. PloS one. 2010 Academic Article GET IT
Times cited: 13
The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells. PloS one. 2010 Academic Article GET IT
Times cited: 28
A mouse model of the human Fragile X syndrome I304N mutation. PLoS genetics. 2009 Academic Article GET IT
Times cited: 98
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 2009 Academic Article GET IT
Times cited: 1429
Tolerance to the neuron-specific paraneoplastic HuD antigen. PloS one. 2009 Academic Article GET IT
Times cited: 23
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Human molecular genetics. 2009 Academic Article GET IT
Times cited: 88
A T-cell receptor associated with naturally occurring human tumor immunity. 2007 GET IT
Times cited: 32
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood. 2006 Academic Article GET IT
Times cited: 52
Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell. 2005 Academic Article GET IT
Times cited: 123
Nova regulates brain-specific splicing to shape the synapse. Nature genetics. 2005 Academic Article GET IT
Times cited: 398
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes & development. 2005 Academic Article GET IT
Times cited: 225
Determination and augmentation of RNA sequence specificity of the Nova K-homology domains. Nucleic acids research. 2004 Academic Article GET IT
Times cited: 23
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 206
Effective antigen cross-presentation by prostate cancer patients' dendritic cells: implications for prostate cancer immunotherapy. Prostate cancer and prostatic diseases. 2004 Academic Article GET IT
Times cited: 13
Neuronal signaling through alternative splicing: some exons CaRRE. Science's STKE : signal transduction knowledge environment. 2001 Review GET IT
Times cited: 1
Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration. Annual review of neuroscience. 2001 Review GET IT
Times cited: 82
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain. Proceedings of the National Academy of Sciences of the United States of America. 2000 Academic Article GET IT
Times cited: 114
Cdr2, a target antigen of naturally occuring human tumor immunity, is widely expressed in gynecological tumors. Cancer research. 2000 Academic Article GET IT
Times cited: 82
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. Cell. 2000 Academic Article GET IT
Times cited: 270
Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration. Annals of neurology. 2000 Academic Article GET IT
Times cited: 215
Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains. Structure (London, England : 1993). 1999 Academic Article GET IT
Times cited: 101
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. Genomics. 1997 Academic Article GET IT
Times cited: 19
Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies. 1993 GET IT
Times cited: 242
A novel antineuronal antibody in stiff-man syndrome. 1993 GET IT
Times cited: 35

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Background

education and training

M.D., Washington University School of Medicine 1985
Ph.D., Washington University 1985
B.A., Columbia University 1979

Contact

full name

Robert B. Darnell

VIVO Weill Cornell Medical College

Robert B. Darnell Adjunct Professor of Neurology and Neuroscience

Publications

selected publications

Background

education and training

Contact

full name