Neuronal signaling through alternative splicing: some exons CaRRE. Review uri icon

Overview

abstract

  • Alternative splicing represents a mechanism by which a single gene can be used to create proteins with different functions. Neurons use alternative splicing to produce channels with different sequences and biophysical or regulatory properties. O'Donovan and Darnell discuss a mechanism by which neurons can alter channel splicing in response to neuronal activity through a signal generated by calcium and calcium/calmodulin-dependent kinase activity.

publication date

  • August 7, 2001

Research

keywords

  • Alternative Splicing
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Exons
  • Neurons
  • RNA
  • Response Elements
  • Signal Transduction

Identity

Scopus Document Identifier

  • 0035822812

Digital Object Identifier (DOI)

  • 10.1126/stke.2001.94.pe2

PubMed ID

  • 11752670

Additional Document Info

volume

  • 2001

issue

  • 94