Crystal, Ronald G

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High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils. Respiratory research. 2023 Letter GET IT
Times cited: 42
Identification of Safe and Effective Intravenous Dose of AAVrh.10hFXN to Treat the Cardiac Manifestations of Friedreich's Ataxia. Human gene therapy. 2023 Academic Article GET IT
Assessment of Residual Full-Length SV40 Large T Antigen in Clinical-grade Adeno-associated Virus Vectors Produced in 293T Cells. Human gene therapy. 2023 Academic Article GET IT
Use of the Iron Chelator Deferiprone to Restore Function in BAL Fluid Macrophages in Smoking and Chronic Obstructive Pulmonary Disease. American journal of respiratory cell and molecular biology. 2023 Letter GET IT
Gene Therapy to Treat Osteopenia Associated With Chronic Ethanol Consumption and Aldehyde Dehydrogenase 2 Deficiency. JBMR plus. 2023 Academic Article GET IT
Safety of Intravenous Administration of an AAV8 Vector Coding for an Oxidation-Resistant Human α1-Antitrypsin for the Treatment of α1-Antitrypsin Deficiency. Human gene therapy. 2023 Academic Article GET IT
Oral epithelium response of electronic cigarette users to electronic cigarette. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2022 Academic Article GET IT
Mixed-Substituted Single-Source Precursors for Si_1-xGe_x Thin Film Deposition. Inorganic chemistry. 2022 Academic Article GET IT
Times cited: 3
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 Review GET IT
Times cited: 19
Impaired differentiation of small airway basal stem/progenitor cells in people living with HIV. Scientific reports. 2022 Academic Article GET IT
Times cited: 2
Genetic Modification of the AAV5 Capsid with Lysine Residues Results in a Lung-Tropic Liver-Detargeted Gene Transfer Vector. Human gene therapy. 2022 Academic Article GET IT
The QChip1 knowledgebase and microarray for precision medicine in Qatar. NPJ genomic medicine. 2022 Academic Article GET IT
Times cited: 2
Novel MYO5B Mutation in Microvillous Inclusion Disease of Syrian Ancestry. Cold Spring Harbor molecular case studies. 2021 Academic Article GET IT
Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency. Cancer gene therapy. 2021 Review GET IT
Metabolic and Metabo-Clinical Signatures of T2D, Obesity, Retinopathy and Dyslipidemia. Diabetes. 2021 Academic Article GET IT
Long-term functional correction of cystathionine β-synthase deficiency in mice by adeno-associated viral gene therapy. Journal of inherited metabolic disease. 2021 Academic Article GET IT
Gene therapy in a murine model of chronic eosinophilic leukemia-not otherwise specified (CEL-NOS). Leukemia. 2021 Academic Article GET IT
Smoking shifts human small airway epithelium club cells toward a lesser differentiated population. NPJ genomic medicine. 2021 Academic Article GET IT
Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids. Respiratory research. 2021 Academic Article GET IT
Epicardial delivery of XC001 gene therapy for refractory angina coronary treatment (The EXACT Trial): Rationale, design, and clinical considerations. American heart journal. 2021 Academic Article GET IT
Automated Retinal Layer Segmentation in CLN2-Associated Disease: Commercially Available Software Characterizing a Progressive Maculopathy. Translational vision science & technology. 2021 Academic Article GET IT
Gene therapy for a murine model of eosinophilic esophagitis. Allergy. 2021 Academic Article GET IT
Times cited: 1
CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts. Respiratory research. 2021 Academic Article GET IT
Times cited: 3
Safety of Direct Intraparenchymal AAVrh.10-Mediated Central Nervous System Gene Therapy for Metachromatic Leukodystrophy. Human gene therapy. 2021 Academic Article GET IT
Times cited: 12
Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells. Scientific reports. 2021 Academic Article GET IT
Times cited: 9
HIV induces airway basal progenitor cells to adopt an inflammatory phenotype. Scientific reports. 2021 Academic Article GET IT
Times cited: 7
Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing CLN2. Science translational medicine. 2020 Academic Article GET IT
Times cited: 27
Quantitative Whole-Body Imaging of I-124-Labeled Adeno-Associated Viral Vector Biodistribution in Nonhuman Primates. Human gene therapy. 2020 Academic Article GET IT
Times cited: 14
Cocaine vaccine dAd5GNE protects against moderate daily and high-dose "binge" cocaine use. PloS one. 2020 Academic Article GET IT
Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). 2020 Academic Article GET IT
Times cited: 4
Reply to Sharma and Zeki: Does Vaping Increase Susceptibility to COVID-19?. American journal of respiratory and critical care medicine. 2020 Letter GET IT
Times cited: 3
Association of vitamin D₃ and its metabolites in patients with and without type 2 diabetes and their relationship to diabetes complications. Therapeutic advances in chronic disease. 2020 Academic Article GET IT
Times cited: 12
Dysregulation of club cell biology in idiopathic pulmonary fibrosis. PloS one. 2020 Academic Article GET IT
Times cited: 16
Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin. JCI insight. 2020 Academic Article GET IT
Times cited: 11
Stress-Induced Mouse Model of the Cardiac Manifestations of Friedreich's Ataxia Corrected by AAV-mediated Gene Therapy. Human gene therapy. 2020 Academic Article GET IT
Times cited: 3
Cell-specific expression of lung disease risk-related genes in the human small airway epithelium. Respiratory research. 2020 Academic Article GET IT
Times cited: 16
Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium. American journal of respiratory and critical care medicine. 2020 Academic Article GET IT
Times cited: 157
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS. Scientific reports. 2020 Academic Article GET IT
Times cited: 10
Qatari Genotype May Contribute to Complications in Type 2 Diabetes. Journal of diabetes research. 2020 Academic Article GET IT
Association of vitamin D₂ and D₃ with type 2 diabetes complications. BMC endocrine disorders. 2020 Academic Article GET IT
Times cited: 14
Identifying novel associations in GWAS by hierarchical Bayesian latent variable detection of differentially misclassified phenotypes. BMC bioinformatics. 2020 Academic Article GET IT
Times cited: 3
Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 Vectors. Human gene therapy. 2020 Academic Article GET IT
Times cited: 9
Association of Differing Qatari Genotypes with Vitamin D Metabolites. International journal of endocrinology. 2020 Academic Article GET IT
Times cited: 32
Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture. Scientific reports. 2020 Academic Article GET IT
Times cited: 33
Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine. 2020 Letter GET IT
Times cited: 30
My Pathway to Gene Therapy. Human gene therapy. 2020 Academic Article GET IT
Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion. Human gene therapy. 2020 Academic Article GET IT
Times cited: 6
Anti-Phospho-Tau Gene Therapy for Chronic Traumatic Encephalopathy. Human gene therapy. 2019 Academic Article GET IT
Times cited: 5
Point of Care Exome Sequencing Reveals Allelic and Phenotypic Heterogeneity Underlying Mendelian disease in Qatar. Human molecular genetics. 2019 Academic Article GET IT
Times cited: 4
Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency. Molecular therapy. Methods & clinical development. 2019 Academic Article GET IT
Times cited: 19
Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity. Respiratory research. 2019 Academic Article GET IT
Times cited: 28
Role of KRAS in regulating normal human airway basal cell differentiation. Respiratory research. 2019 Academic Article GET IT
Times cited: 2
Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes. The European respiratory journal. 2019 Academic Article GET IT
Times cited: 22
Gene therapy for C1 esterase inhibitor deficiency in a Murine Model of Hereditary angioedema. Allergy. 2019 Academic Article GET IT
Times cited: 30
Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome. American journal of respiratory and critical care medicine. 2018 Academic Article GET IT
Times cited: 13
Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia. Annals of neurology. 2018 Academic Article GET IT
Times cited: 13
Ontogeny and Biology of Human Small Airway Epithelial Club Cells. American journal of respiratory and critical care medicine. 2018 Academic Article GET IT
Times cited: 60
Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts. Epigenomics. 2018 Academic Article GET IT
Times cited: 3
Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease). Scientific reports. 2018 Academic Article GET IT
Times cited: 14
Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population. PloS one. 2018 Academic Article GET IT
Times cited: 4
Genome-wide association study of lung function and clinical implication in heavy smokers. BMC medical genetics. 2018 Academic Article GET IT
Times cited: 22
Disease characteristics and progression in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease: an observational cohort study. The Lancet. Child & adolescent health. 2018 Academic Article GET IT
Times cited: 74
Rural Residence and Chronic Obstructive Pulmonary Disease Exacerbations. Analysis of the SPIROMICS Cohort. Annals of the American Thoracic Society. 2018 Academic Article GET IT
Times cited: 26
In Vivo Potency Assay for Adeno-Associated Virus-Based Gene Therapy Vectors Using AAVrh.10 as an Example. Human gene therapy methods. 2018 Academic Article GET IT
Times cited: 9
Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes. Respiratory research. 2018 Academic Article GET IT
Times cited: 82
p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells. The Journal of thoracic and cardiovascular surgery. 2018 Academic Article GET IT
Times cited: 11
Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2. Experimental neurology. 2018 Academic Article GET IT
Times cited: 10
Point-of-care whole-exome sequencing of idiopathic male infertility. Genetics in medicine : official journal of the American College of Medical Genetics. 2018 Academic Article GET IT
Times cited: 41
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease. Human gene therapy. Clinical development. 2018 Academic Article GET IT
Times cited: 70
Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration. Oncotarget. 2018 Academic Article GET IT
Times cited: 7
A systematic review on the genetics of male infertility in the era of next-generation sequencing. Arab journal of urology. 2018 Academic Article GET IT
Times cited: 29
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population. Nature communications. 2018 Academic Article GET IT
Times cited: 41
Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort. The Lancet. Respiratory medicine. 2017 Academic Article GET IT
Times cited: 172
Smoking-Dependent Distal-to-Proximal Repatterning of the Adult Human Small Airway Epithelium. American journal of respiratory and critical care medicine. 2017 Academic Article GET IT
Times cited: 52
Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: an uncontrolled phase 1/2 clinical trial. The Lancet. Neurology. 2017 Academic Article GET IT
Times cited: 84
Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium. Autophagy. 2017 Academic Article GET IT
Times cited: 38
An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci. PLoS computational biology. 2017 Academic Article GET IT
Times cited: 7
HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype. Cell reports. 2017 Academic Article GET IT
Times cited: 10
Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling. Stem cell reviews and reports. 2017 Academic Article GET IT
Times cited: 10
Waterpipe smoking induces epigenetic changes in the small airway epithelium. PloS one. 2017 Academic Article GET IT
Times cited: 26
Radioiodinated Capsids Facilitate In Vivo Non-Invasive Tracking of Adeno-Associated Gene Transfer Vectors. Scientific reports. 2017 Academic Article GET IT
Times cited: 13
Genetic Modification of the Lung Directed Toward Treatment of Human Disease. Human gene therapy. 2017 Review GET IT
Times cited: 23
Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 Academic Article GET IT
Times cited: 46
Compelling evidence for the efficacy of α1-antitrypsin augmentation treatment for α1-antitrypsin deficiency. The Lancet. Respiratory medicine. 2016 Comment GET IT
Times cited: 2
EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium. Stem cells (Dayton, Ohio). 2016 Academic Article GET IT
Times cited: 42
Gene therapy for metachromatic leukodystrophy. Journal of neuroscience research. 2016 Review GET IT
Times cited: 52
Anti-Epidermal Growth Factor Receptor Gene Therapy for Glioblastoma. PloS one. 2016 Academic Article GET IT
Times cited: 18
Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques. Pharmacology, biochemistry, and behavior. 2016 Academic Article GET IT
Times cited: 21
In situ reprogramming to transdifferentiate fibroblasts into cardiomyocytes using adenoviral vectors: Implications for clinical myocardial regeneration. The Journal of thoracic and cardiovascular surgery. 2016 Academic Article GET IT
Times cited: 39
Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers. American journal of respiratory and critical care medicine. 2016 Academic Article GET IT
Times cited: 21
Correction: Type 2 Diabetes Risk Allele Loci in the Qatari Population. PloS one. 2016 Article GET IT
Times cited: 20
JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium. Stem cell reviews and reports. 2016 Academic Article GET IT
Times cited: 17
Sarcoidosis in America. Analysis Based on Health Care Use. Annals of the American Thoracic Society. 2016 Academic Article GET IT
Times cited: 120
Persistence of circulating endothelial microparticles in COPD despite smoking cessation. Thorax. 2016 Academic Article GET IT
Times cited: 37
Type 2 Diabetes Risk Allele Loci in the Qatari Population. PloS one. 2016 Academic Article GET IT
Times cited: 20
The Qatar genome: a population-specific tool for precision medicine in the Middle East. Human genome variation. 2016 Academic Article GET IT
Times cited: 74
Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy. The Journal of allergy and clinical immunology. 2016 Academic Article GET IT
Times cited: 18
The Role of Interleukin-23 in the Early Development of Emphysema in HIV1(+) Smokers. Journal of immunology research. 2016 Academic Article GET IT
Times cited: 8
Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels. The European respiratory journal. 2016 Letter GET IT
Times cited: 3
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models. Neurobiology of aging. 2016 Academic Article GET IT
Times cited: 31
Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort. Thorax. 2016 Academic Article GET IT
Times cited: 271
POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 32
Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype. American journal of respiratory cell and molecular biology. 2016 Academic Article GET IT
Times cited: 26
Brain Region-Specific Degeneration with Disease Progression in Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2 Disease). AJNR. American journal of neuroradiology. 2016 Academic Article GET IT
Times cited: 18
Cigarette Smoking Induces Changes in Airway Epithelial Expression of Genes Associated with Monogenic Lung Disorders. American journal of respiratory and critical care medicine. 2016 Letter GET IT
Times cited: 7
Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations. Genome research. 2016 Academic Article GET IT
Times cited: 62
Serum Metabolite Biomarkers Discriminate Healthy Smokers from COPD Smokers. PloS one. 2015 Academic Article GET IT
Times cited: 38
Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity. The European respiratory journal. 2015 Academic Article GET IT
Times cited: 83
Copy number variations in the genome of the Qatari population. BMC genomics. 2015 Academic Article GET IT
Times cited: 8
Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. Journal of cell science. 2015 Academic Article GET IT
Times cited: 10
Augmentation treatment for α1 antitrypsin deficiency. Lancet (London, England). 2015 Comment GET IT
Times cited: 6
Intracerebral Gene Therapy Using AAVrh.10-hARSA Recombinant Vector to Treat Patients with Early-Onset Forms of Metachromatic Leukodystrophy: Preclinical Feasibility and Safety Assessments in Nonhuman Primates. Human gene therapy. Clinical development. 2015 Academic Article GET IT
Times cited: 51
Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation. PloS one. 2015 Academic Article GET IT
Times cited: 56
Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PloS one. 2015 Academic Article GET IT
Times cited: 49
Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population. Journal of translational medicine. 2015 Academic Article GET IT
Times cited: 13
Evaluation of compounded bevacizumab prepared for intravitreal injection. JAMA ophthalmology. 2015 Academic Article GET IT
Times cited: 33
Genetic modification of neurons to express bevacizumab for local anti-angiogenesis treatment of glioblastoma. Cancer gene therapy. 2014 Academic Article GET IT
Times cited: 16
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1. EMBO reports. 2014 Academic Article GET IT
Times cited: 15
FOXJ1 prevents cilia growth inhibition by cigarette smoke in human airway epithelium in vitro. American journal of respiratory cell and molecular biology. 2014 Academic Article GET IT
Times cited: 57
Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine. 2014 Letter GET IT
Times cited: 70
Intra-arterial delivery of AAV vectors to the mouse brain after mannitol mediated blood brain barrier disruption. Journal of controlled release : official journal of the Controlled Release Society. 2014 Academic Article GET IT
Times cited: 64
Smoking accelerates aging of the small airway epithelium. Respiratory research. 2014 Academic Article GET IT
Times cited: 57
Phase I/II study of intrapleural administration of a serotype rh.10 replication-deficient adeno-associated virus gene transfer vector expressing the human α1-antitrypsin cDNA to individuals with α1-antitrypsin deficiency. Human gene therapy. Clinical development. 2014 Academic Article GET IT
Times cited: 15
Comparative efficacy and safety of multiple routes of direct CNS administration of adeno-associated virus gene transfer vector serotype rh.10 expressing the human arylsulfatase A cDNA to nonhuman primates. Human gene therapy. Clinical development. 2014 Academic Article GET IT
Times cited: 45
AAV-mediated persistent bevacizumab therapy suppresses tumor growth of ovarian cancer. Gynecologic oncology. 2014 Academic Article GET IT
Times cited: 23
Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Human gene therapy. 2014 Review GET IT
Times cited: 12
Intracerebral administration of adeno-associated viral vector serotype rh.10 carrying human SGSH and SUMF1 cDNAs in children with mucopolysaccharidosis type IIIA disease: results of a phase I/II trial. Human gene therapy. 2014 Academic Article GET IT
Times cited: 156
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia. Nature medicine. 2014 Academic Article GET IT
Times cited: 120
"Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. The Journal of thoracic and cardiovascular surgery. 2014 Academic Article GET IT
Times cited: 36
Partial correction of the CNS lysosomal storage defect in a mouse model of juvenile neuronal ceroid lipofuscinosis by neonatal CNS administration of an adeno-associated virus serotype rh.10 vector expressing the human CLN3 gene. Human gene therapy. 2014 Academic Article GET IT
Times cited: 34
Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Human gene therapy. Clinical development. 2014 Academic Article GET IT
Times cited: 26
Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. PloS one. 2014 Academic Article GET IT
Times cited: 56
Intraflagellar transport gene expression associated with short cilia in smoking and COPD. PloS one. 2014 Academic Article GET IT
Times cited: 58
Adenovirus: the first effective in vivo gene delivery vector. Human gene therapy. 2014 Review GET IT
Times cited: 220
Basal cell origins of smoking-induced airway epithelial disorders. Cell cycle (Georgetown, Tex.). 2013 Editorial Article GET IT
Times cited: 19
HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors. Bioinformatics (Oxford, England). 2013 Academic Article GET IT
Times cited: 17
Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity. Respiratory research. 2013 Academic Article GET IT
Times cited: 81
Are the smoking-induced diseases an acquired form of cystic fibrosis?. American journal of respiratory and critical care medicine. 2013 Editorial Article GET IT
Times cited: 3
Intrapleural administration of an AAVrh.10 vector coding for human α1-antitrypsin for the treatment of α1-antitrypsin deficiency. Human gene therapy. Clinical development. 2013 Academic Article GET IT
Times cited: 39
Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. BMC medical genetics. 2013 Academic Article GET IT
Times cited: 7
Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway. Human molecular genetics. 2013 Academic Article GET IT
Times cited: 105
Cannulation of the internal carotid artery in mice: a novel technique for intra-arterial delivery of therapeutics. Journal of neuroscience methods. 2013 Academic Article GET IT
Times cited: 8
Exome sequencing identifies potential risk variants for Mendelian disorders at high prevalence in Qatar. Human mutation. 2013 Academic Article GET IT
Times cited: 41
Gene therapy to stimulate angiogenesis to treat diffuse coronary artery disease. Human gene therapy. 2013 Review GET IT
Times cited: 19
Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations. The American journal of cardiology. 2013 Academic Article GET IT
Times cited: 12
High correlation of the response of upper and lower lobe small airway epithelium to smoking. PloS one. 2013 Academic Article GET IT
Times cited: 5
Innate immunity and chronic obstructive pulmonary disease: a mini-review. Gerontology. 2013 Review GET IT
Times cited: 58
Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer. Stem cells (Dayton, Ohio). 2013 Academic Article GET IT
Times cited: 24
Smoking-induced CXCL14 expression in the human airway epithelium links chronic obstructive pulmonary disease to lung cancer. American journal of respiratory cell and molecular biology. 2013 Academic Article GET IT
Times cited: 29
Spectrum of ocular manifestations in CLN2-associated batten (Jansky-Bielschowsky) disease correlate with advancing age and deteriorating neurological function. PloS one. 2013 Academic Article GET IT
Times cited: 32
Differential expression of vitamin E and selenium-responsive genes by disease severity in chronic obstructive pulmonary disease. COPD. 2013 Academic Article GET IT
Times cited: 8
RGD capsid modification enhances mucosal protective immunity of a non-human primate adenovirus vector expressing Pseudomonas aeruginosa OprF. Clinical and experimental immunology. 2013 Academic Article GET IT
Times cited: 18
Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression. Human molecular genetics. 2013 Academic Article GET IT
Times cited: 84
RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium. Respiratory research. 2013 Academic Article GET IT
Times cited: 55
EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 73
Suppression of nicotine-induced pathophysiology by an adenovirus hexon-based antinicotine vaccine. Human gene therapy. 2013 Academic Article GET IT
Times cited: 16
Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2013 Academic Article GET IT
Times cited: 38
Lung adenocarcinoma subtypes based on expression of human airway basal cell genes. The European respiratory journal. 2013 Academic Article GET IT
Times cited: 30
Alpha-1 antitrypsin augmentation therapy. COPD. 2013 Review GET IT
Times cited: 27
Safety of direct cardiac administration of AdVEGF-All6A+, a replication-deficient adenovirus vector cDNA/genomic hybrid expressing all three major isoforms of human vascular endothelial growth factor, to the ischemic myocardium of rats. Human gene therapy. Clinical development. 2013 Academic Article GET IT
Times cited: 9
Lumbar spine intervertebral disc gene delivery: a pilot study in lewis rats. HSS journal : the musculoskeletal journal of Hospital for Special Surgery. 2013 Academic Article GET IT
Times cited: 5
Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Human gene therapy. 2012 Academic Article GET IT
Times cited: 20
Long-term follow-up assessment of a phase 1 trial of angiogenic gene therapy using direct intramyocardial administration of an adenoviral vector expressing the VEGF121 cDNA for the treatment of diffuse coronary artery disease. Human gene therapy. 2012 Academic Article GET IT
Times cited: 35
In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor. Journal of the American Heart Association. 2012 Academic Article GET IT
Times cited: 106
Exome sequencing of only seven Qataris identifies potentially deleterious variants in the Qatari population. PloS one. 2012 Academic Article GET IT
Times cited: 16
Long-term expression and safety of administration of AAVrh.10hCLN2 to the brain of rats and nonhuman primates for the treatment of late infantile neuronal ceroid lipofuscinosis. Human gene therapy methods. 2012 Academic Article GET IT
Times cited: 75
Assessment of disease severity in late infantile neuronal ceroid lipofuscinosis using multiparametric MR imaging. AJNR. American journal of neuroradiology. 2012 Academic Article GET IT
Times cited: 16
Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD. Human genetics. 2012 Academic Article GET IT
Times cited: 35
Airway epithelial expression of TLR5 is downregulated in healthy smokers and smokers with chronic obstructive pulmonary disease. Journal of immunology (Baltimore, Md. : 1950). 2012 Academic Article GET IT
Times cited: 25
Correction of brain oligodendrocytes by AAVrh.10 intracerebral gene therapy in metachromatic leukodystrophy mice. Human gene therapy. 2012 Academic Article GET IT
Times cited: 69
AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Science translational medicine. 2012 Academic Article GET IT
Times cited: 47
Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations. BMC genetics. 2012 Academic Article GET IT
Times cited: 42
In vivo gene transfer strategies to achieve partial correction of von Willebrand disease. Human gene therapy. 2012 Academic Article GET IT
Times cited: 17
Empirical Bayes conditional independence graphs for regulatory network recovery. Bioinformatics (Oxford, England). 2012 Academic Article GET IT
Times cited: 5
Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers. BMC medical genomics. 2012 Academic Article GET IT
Times cited: 44
Novel therapies, high-risk pediatric research, and the prospect of benefit: learning from the ethical disagreements. Molecular therapy : the journal of the American Society of Gene Therapy. 2012 Academic Article GET IT
Times cited: 2
The challenge of using gene- or cell-based therapies to treat lung disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2012 Editorial Article GET IT
Times cited: 2
AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Human gene therapy. 2012 Academic Article GET IT
Times cited: 38
Cardiac biointerventions: whatever happened to stem cell and gene therapy?. Innovations (Philadelphia, Pa.). 2012 Review GET IT
Times cited: 10
Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells. Cellular and molecular life sciences : CMLS. 2012 Academic Article GET IT
Times cited: 22
RNA-Seq quantification of the human small airway epithelium transcriptome. BMC genomics. 2012 Academic Article GET IT
Times cited: 94
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 2011 Academic Article GET IT
Times cited: 361
Persistent suppression of ocular neovascularization with intravitreal administration of AAVrh.10 coding for bevacizumab. Human gene therapy. 2011 Academic Article GET IT
Times cited: 20
Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011 Academic Article GET IT
Times cited: 71
Biologic phenotyping of the human small airway epithelial response to cigarette smoking. PloS one. 2011 Academic Article GET IT
Times cited: 60
When ethics constrains clinical research: trial design of control arms in "greater than minimal risk" pediatric trials. Human gene therapy. 2011 Academic Article GET IT
Times cited: 10
The human airway epithelial basal cell transcriptome. PloS one. 2011 Academic Article GET IT
Times cited: 150
Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. PloS one. 2011 Academic Article GET IT
Times cited: 86
Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers. American journal of respiratory and critical care medicine. 2011 Academic Article GET IT
Times cited: 180
Glutathione S-transferase copy number variation alters lung gene expression. The European respiratory journal. 2011 Academic Article GET IT
Times cited: 17
Modulation of cystatin A expression in human airway epithelium related to genotype, smoking, COPD, and lung cancer. Cancer research. 2011 Academic Article GET IT
Times cited: 33
Protective anti-Pseudomonas aeruginosa humoral and cellular mucosal immunity by AdC7-mediated expression of the P. aeruginosa protein OprF. Vaccine. 2011 Academic Article GET IT
Times cited: 29
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Molecular therapy : the journal of the American Society of Gene Therapy. 2011 Academic Article GET IT
Times cited: 53
Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium. Respiratory research. 2010 Academic Article GET IT
Times cited: 20
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. American journal of physiology. Lung cellular and molecular physiology. 2010 Academic Article GET IT
Times cited: 246
Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo. Cellular and molecular life sciences : CMLS. 2010 Academic Article GET IT
Times cited: 160
Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals. Chest. 2010 Academic Article GET IT
Times cited: 42
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Gene therapy for late infantile neuronal ceroid lipofuscinosis: neurosurgical considerations. Journal of neurosurgery. Pediatrics. 2010 Academic Article GET IT
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AAVrh.10-mediated genetic delivery of bevacizumab to the pleura to provide local anti-VEGF to suppress growth of metastatic lung tumors. Gene therapy. 2010 Academic Article GET IT
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Protective immunity against a lethal respiratory Yersinia pestis challenge induced by V antigen or the F1 capsular antigen incorporated into adenovirus capsid. Human gene therapy. 2010 Academic Article GET IT
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Mesothelioma: an inviting but challenging target for gene therapy. American journal of respiratory cell and molecular biology. 2010 Editorial Article GET IT
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Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing. Human gene therapy. 2009 Academic Article GET IT
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Thrombopoietin gene transfer-mediated enhancement of angiogenic responses to acute ischemia. Circulation research. 2005 Academic Article GET IT
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Gene transfer-mediated pre-mRNA segmental trans-splicing as a strategy to deliver intracellular toxins for cancer therapy. Cancer research. 2005 Academic Article GET IT
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The bronchopulmonary pathology of alpha-1 antitrypsin (AAT) deficiency: findings of the Death Review Committee of the national registry for individuals with Severe Deficiency of Alpha-1 Antitrypsin. Human pathology. 2004 Academic Article GET IT
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Homozygous deletion of early growth response 1 gene and critical limb ischemia after vascular ligation in mice: evidence for a central role in vascular homeostasis. The Journal of thoracic and cardiovascular surgery. 2004 Academic Article GET IT
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Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2004 Academic Article GET IT
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Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses. Journal of virology. 2004 Academic Article GET IT
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Augmenting major histocompatibility complex class I expression by murine tumors in vivo enhances antitumor immunity induced by an active immunotherapy strategy. The Journal of thoracic and cardiovascular surgery. 2004 Academic Article GET IT
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Protective immunity evoked against anthrax lethal toxin after a single intramuscular administration of an adenovirus-based vaccine encoding humanized protective antigen. Human gene therapy. 2003 Academic Article GET IT
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Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2003 Academic Article GET IT
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Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells. Blood. 2003 Academic Article GET IT
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Phase I study of direct administration of a replication deficient adenovirus vector containing the vascular endothelial growth factor cDNA (CI-1023) to patients with claudication. The American journal of cardiology. 2002 Academic Article GET IT
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Gene transfer to the pleural mesothelium as a strategy to deliver proteins to the lung parenchyma. Human gene therapy. 2002 Academic Article GET IT
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Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors. American journal of respiratory cell and molecular biology. 2002 Academic Article GET IT
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Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of congestive heart failure. The Journal of thoracic and cardiovascular surgery. 2002 Academic Article GET IT
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Adenovirus vector-mediated transfer of the vascular endothelial growth factor cDNA to healing abdominal fascia enhances vascularity and bursting strength in mice with normal and impaired wound healing. Surgery. 2002 Academic Article GET IT
Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand. Journal of hematotherapy & stem cell research. 2002 Academic Article GET IT
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Formation of vascularized meniscal tissue by combining gene therapy with tissue engineering. Tissue engineering. 2002 Academic Article GET IT
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Intratumoral administration of low doses of an adenovirus vector encoding tumor necrosis factor alpha together with naive dendritic cells elicits significant suppression of tumor growth without toxicity. Human gene therapy. 2001 Academic Article GET IT
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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature medicine. 2001 Academic Article GET IT
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Upregulation of transcription factors in lung in the early phase of postpneumonectomy lung growth. American journal of physiology. Lung cellular and molecular physiology. 2001 Academic Article GET IT
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Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors. Cancer research. 2001 Academic Article GET IT
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Antigen-pulsed dendritic cells expressing macrophage-derived chemokine elicit Th2 responses and promote specific humoral immunity. The Journal of clinical investigation. 2001 Academic Article GET IT
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Enhanced matrix synthesis and in vitro formation of cartilage-like tissue by genetically modified chondrocytes expressing BMP-7. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2001 Academic Article GET IT
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Adenovirus-mediated gene transfer of VEGF(121) improves lower-extremity endothelial function and flow reserve. Circulation. 2001 Academic Article GET IT
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Cross-strain protection against clinical and laboratory strains of Pseudomonas aeruginosa mediated by dendritic cells genetically modified to express CD40 ligand and pulsed with specific strains of Pseudomonas aeruginosa. Human gene therapy. 2001 Academic Article GET IT
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Compartmentalization of vascular endothelial growth factor to the epithelial surface of the human lung. Molecular medicine (Cambridge, Mass.). 2001 Academic Article GET IT
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Percutaneous endocardial transfer and expression of genes to the myocardium utilizing fluoroscopic guidance. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2001 Academic Article GET IT
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Manipulation of the cytoplasmic and transmembrane domains alters cell surface levels of the coxsackie-adenovirus receptor and changes the efficiency of adenovirus infection. Human gene therapy. 2001 Academic Article GET IT
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Evaluation of clinical parameters to predict Mycobacterium tuberculosis in inpatients. Archives of internal medicine. 2000 Academic Article GET IT
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Immunolocalization of proliferating cells in the rabbit iliac artery after balloon angioplasty. Journal of vascular and interventional radiology : JVIR. 2000 Academic Article GET IT
Coarse spray delivery to a localized region of the pulmonary airways for gene therapy. Human gene therapy. 2000 Academic Article GET IT
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Bad for cats, good for humans? Modified feline immunodeficiency virus for gene therapy. The Journal of clinical investigation. 1999 Comment GET IT
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Granulocyte-macrophage colony-stimulating factor gene transfer to dendritic cells or epidermal cells augments their antigen-presenting function including induction of anti-tumor immunity. The Journal of investigative dermatology. 1999 Academic Article GET IT
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Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus. The Journal of clinical investigation. 1999 Academic Article GET IT
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Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma. Cancer gene therapy. 1999 Academic Article GET IT
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Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. The Journal of clinical investigation. 1999 Academic Article GET IT
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Limited diversity of gamma delta T-cell antigen receptor junctional region sequences in individuals with sarcoidosis compared to broad diversity in normal subjects. Transactions of the Association of American Physicians. 1990 Academic Article GET IT
Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele. Molecular and cellular biology. 1990 Academic Article GET IT
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Strategies for aerosol therapy of alpha 1-antitrypsin deficiency by the aerosol route. Lung. 1990 Academic Article GET IT
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Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet (London, England). 1989 Academic Article GET IT
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Characterization of the intracellular mechanism causing the alpha-1-antitrypsin Nullgranite falls deficiency state. The American review of respiratory disease. 1989 Academic Article GET IT
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Characterization of the sequence of the normal alpha-1-antitrypsin M3 allele and function of the M3 protein. American journal of respiratory cell and molecular biology. 1989 Academic Article GET IT
Times cited: 3
Morphologic characterization of alveolar macrophages from subjects with occupational exposure to inorganic particles. The American review of respiratory disease. 1989 Academic Article GET IT
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Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lung. The Journal of infectious diseases. 1989 Academic Article GET IT
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Guidelines for the approach to the patient with severe hereditary alpha-1-antitrypsin deficiency. American Thoracic Society. The American review of respiratory disease. 1989 Review GET IT
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Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency. The Journal of clinical investigation. 1989 Academic Article GET IT
Times cited: 97
Ribonuclease A cleavage combined with the polymerase chain reaction for detection of the Z mutation of the alpha-1-antitrypsin gene. American journal of respiratory cell and molecular biology. 1989 Academic Article GET IT
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Characterization of the coding sequence of the normal M4 alpha 1-antitrypsin gene. Biochemical and biophysical research communications. 1989 Academic Article GET IT
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Anti-neutrophil-elastase defenses of the lower respiratory tract in alpha 1-antitrypsin deficiency directly augmented with an aerosol of alpha 1-antitrypsin. Annals of internal medicine. 1989 Academic Article GET IT
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Rapid, nonradioactive detection of mutations in the human genome by allele-specific amplification. The Journal of laboratory and clinical medicine. 1989 Academic Article GET IT
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Expression of HLA class II genes in alveolar macrophages of patients with sarcoidosis. The American review of respiratory disease. 1989 Academic Article GET IT
Times cited: 37
Serum alpha 1-antitrypsin deficiency associated with the common S-type (Glu264----Val) mutation results from intracellular degradation of alpha 1-antitrypsin prior to secretion. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 65
Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T cells. The New England journal of medicine. 1989 Academic Article GET IT
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Expression of the neutrophil elastase gene during human bone marrow cell differentiation. The Journal of experimental medicine. 1989 Academic Article GET IT
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A Pro----Leu substitution in codon 369 of the alpha-1-antitrypsin deficiency variant PI MHeerlen. Human genetics. 1989 Academic Article GET IT
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Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis. The American review of respiratory disease. 1989 Academic Article GET IT
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Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 69
Repair of the secretion defect in the Z form of alpha 1-antitrypsin by addition of a second mutation. Science (New York, N.Y.). 1988 Academic Article GET IT
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Alveolar macrophages release an insulin-like growth factor I-type molecule. The Journal of clinical investigation. 1988 Academic Article GET IT
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Evaluation of fibronectin gene expression by in situ hybridization. Differential expression of the fibronectin gene among populations of human alveolar macrophages. The American journal of pathology. 1988 Academic Article GET IT
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Evaluation of the in vitro and in vivo effects of cyclosporine on the lung T-lymphocyte alveolitis of active pulmonary sarcoidosis. The American review of respiratory disease. 1988 Academic Article GET IT
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Characterization of the gene and protein of the alpha 1-antitrypsin "deficiency" allele Mprocida. The Journal of biological chemistry. 1988 Academic Article GET IT
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Structure of the human neutrophil elastase gene. The Journal of biological chemistry. 1988 Academic Article GET IT
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Bias toward use of a specific T cell receptor beta-chain variable region in a subgroup of individuals with sarcoidosis. The Journal of clinical investigation. 1988 Academic Article GET IT
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Molecular genetics in pulmonary emphysema. The American review of respiratory disease. 1988 Academic Article GET IT
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Cloning and characterization of an alpha 1-antitrypsin like gene 12 KB downstream of the genuine alpha 1-antitrypsin gene. Biochemical and biophysical research communications. 1988 Academic Article GET IT
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Biochemical efficacy and safety of monthly augmentation therapy for alpha 1-antitrypsin deficiency. JAMA. 1988 Academic Article GET IT
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Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele. American journal of human genetics. 1988 Academic Article GET IT
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Differential expression of the tumor necrosis factor/cachectin gene by blood and lung mononuclear phagocytes. The American review of respiratory disease. 1988 Academic Article GET IT
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Spontaneous expression of the interleukin 2 receptor gene and presence of functional interleukin 2 receptors on T lymphocytes in the blood of individuals with active pulmonary sarcoidosis. The Journal of clinical investigation. 1988 Academic Article GET IT
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Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms. The American review of respiratory disease. 1988 Academic Article GET IT
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Demonstration by in situ hybridization of dissimilar IL-1 beta gene expression in human alveolar macrophages and blood monocytes in response to lipopolysaccharide. Journal of immunology (Baltimore, Md. : 1950). 1988 Academic Article GET IT
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High levels of transforming growth factor-beta are present in the epithelial lining fluid of the normal human lower respiratory tract. The American review of respiratory disease. 1988 Academic Article GET IT
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Sarcoidosis is not associated with a generalized defect in T cell suppressor function. Journal of immunology (Baltimore, Md. : 1950). 1988 Academic Article GET IT
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Functional significance of anti-T-lymphocyte antibodies in sarcoidosis. The American review of respiratory disease. 1988 Academic Article GET IT
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Myelomonocytic cell lineage expression of the neutrophil elastase gene. The Journal of biological chemistry. 1988 Academic Article GET IT
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Accumulation of Langerhans' cells on the epithelial surface of the lower respiratory tract in normal subjects in association with cigarette smoking. The American review of respiratory disease. 1988 Academic Article GET IT
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Evaluation of the S-type of alpha-1-antitrypsin as an in vivo and in vitro inhibitor of neutrophil elastase. The American review of respiratory disease. 1988 Academic Article GET IT
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T lymphocytes compartmentalized on the epithelial surface of the lower respiratory tract express the very late activation antigen complex VLA-1. Clinical immunology and immunopathology. 1988 Academic Article GET IT
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Colchicine suppresses the release of fibroblast growth factors from alveolar macrophages in vitro. The basis of a possible therapeutic approach ot the fibrotic disorders. The American review of respiratory disease. 1988 Academic Article GET IT
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Does de novo immunoglobulin synthesis occur on the epithelial surface of the human lower respiratory tract?. The American review of respiratory disease. 1988 Academic Article GET IT
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Characterization of the lower respiratory tract inflammation of nonsmoking individuals with interstitial lung disease associated with chronic inhalation of inorganic dusts. The American review of respiratory disease. 1987 Academic Article GET IT
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Modulation of fibronectin gene expression in human mononuclear phagocytes. The Journal of clinical investigation. 1987 Academic Article GET IT
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Augmentation of lung antineutrophil elastase capacity with recombinant human alpha-1-antitrypsin. Journal of applied physiology (Bethesda, Md. : 1985). 1987 Academic Article GET IT
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Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase. The Journal of clinical investigation. 1987 Academic Article GET IT
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Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase. The Journal of clinical investigation. 1987 Academic Article GET IT
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alpha 1-Antitrypsin nullGranite Falls, a nonexpressing alpha 1-antitrypsin gene associated with a frameshift to stop mutation in a coding exon. The Journal of biological chemistry. 1987 Academic Article GET IT
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Characterization of the M1(Ala213) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype. Biochemistry. 1987 Academic Article GET IT
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Clonal gene therapy: transplanted mouse fibroblast clones express human alpha 1-antitrypsin gene in vivo. Science (New York, N.Y.). 1987 Academic Article GET IT
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Corticosteroid therapy suppresses spontaneous interleukin 2 release and spontaneous proliferation of lung T lymphocytes of patients with active pulmonary sarcoidosis. Journal of immunology (Baltimore, Md. : 1950). 1987 Academic Article GET IT
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Mechanisms of macrophage accumulation in the lungs of asbestos-exposed subjects. The American review of respiratory disease. 1987 Academic Article GET IT
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Pharmacologic suppression of the neutrophil component of the alveolitis in idiopathic pulmonary fibrosis. The American review of respiratory disease. 1987 Academic Article GET IT
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Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. The New England journal of medicine. 1987 Academic Article GET IT
Evaluation of alveolar macrophages in normals and individuals with active pulmonary sarcoidosis for the spontaneous expression of the interleukin-1 beta gene. Cellular immunology. 1987 Academic Article GET IT
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Normal alveolar epithelial lining fluid contains high levels of glutathione. Journal of applied physiology (Bethesda, Md. : 1985). 1987 Academic Article GET IT
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Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis. The Journal of clinical investigation. 1987 Academic Article GET IT
Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema. The New England journal of medicine. 1987 Academic Article GET IT
Evaluation of tamoxifen as a therapy to augment alpha-1-antitrypsin concentrations in Z homozygous alpha-1-antitrypsin-deficient subjects. The American review of respiratory disease. 1987 Academic Article GET IT
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Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector. Proceedings of the National Academy of Sciences of the United States of America. 1987 Academic Article GET IT
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Susceptibility to experimental interstitial lung disease is modified by immune- and non-immune-related genes. The American review of respiratory disease. 1987 Academic Article GET IT
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Clonal gene therapy: in vivo expression of a transplanted monoclonal population of murine fibroblasts containing a retrovirus inserted human alpha 1-antitrypsin gene. Transactions of the Association of American Physicians. 1987 Academic Article GET IT
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Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract. Journal of applied physiology (Bethesda, Md. : 1985). 1987 Academic Article GET IT
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Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene. The Journal of biological chemistry. 1986 Academic Article GET IT
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Compartmentalized activation of the interleukin 2 gene by lung T lymphocytes in active pulmonary sarcoidosis. Journal of immunology (Baltimore, Md. : 1950). 1986 Academic Article GET IT
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RNA structural elements for expression in Escherichia coli. Alpha 1-antitrypsin synthesis using translation control elements based on the cII ribosome-binding site of phage lambda. FEBS letters. 1986 Academic Article GET IT
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Altered specificities of genetically engineered alpha 1 antitrypsin variants. Protein engineering. 1986 Academic Article GET IT
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Antiprotease targeting: altered specificity of alpha 1-antitrypsin by amino acid replacement at the reactive centre. Revue francaise de transfusion et immuno-hematologie. 1986 Academic Article GET IT
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Evaluation of danazol therapy for patients with PiZZ alpha-1-antitrypsin deficiency. The American review of respiratory disease. 1986 Academic Article GET IT
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Bronchoalveolar lavage. The report of an international conference. Chest. 1986 Academic Article GET IT
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Spontaneous expression of the c-sis gene and release of a platelet-derived growth factorlike molecule by human alveolar macrophages. The Journal of clinical investigation. 1986 Academic Article GET IT
Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals. The Journal of clinical investigation. 1986 Academic Article GET IT
Spontaneous release of interleukin 2 by lung T lymphocytes in active pulmonary sarcoidosis is primarily from the Leu3+DR+ T cell subset. The Journal of clinical investigation. 1986 Academic Article GET IT
Human type III collagen gene expression is coordinately modulated with the type I collagen genes during fibroblast growth. Biochemistry. 1986 Academic Article GET IT
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Intraluminal fibrosis in interstitial lung disorders. The American journal of pathology. 1986 Academic Article GET IT
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Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. The Journal of clinical investigation. 1986 Academic Article GET IT
Expression of the transferrin receptor gene during the process of mononuclear phagocyte maturation. Journal of immunology (Baltimore, Md. : 1950). 1986 Academic Article GET IT
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Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. Journal of applied physiology (Bethesda, Md. : 1985). 1986 Academic Article GET IT
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Evaluation of "at risk" alpha 1-antitrypsin genotype SZ with synthetic oligonucleotide gene probes. The Journal of clinical investigation. 1986 Academic Article GET IT
Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity. Nature. 1986 Academic Article GET IT
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Urinary excretion of desmosine (elastin cross-links) in subjects with PiZZ alpha-1-antitrypsin deficiency, a phenotype associated with hereditary predisposition to pulmonary emphysema. The American review of respiratory disease. 1985 Academic Article GET IT
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Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency. Biochemical and biophysical research communications. 1985 Academic Article GET IT
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Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis. The Journal of clinical investigation. 1985 Academic Article GET IT
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Evidence for chronic inflammation as a component of the interstitial lung disease associated with progressive systemic sclerosis. The American review of respiratory disease. 1985 Academic Article GET IT
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Patterns of pulmonary structural remodeling after experimental paraquat toxicity. The morphogenesis of intraalveolar fibrosis. The American journal of pathology. 1985 Academic Article GET IT
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"Interstitial pathology': an overview of the chronic interstitial lung disorders. International archives of allergy and applied immunology. 1985 Academic Article GET IT
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Characterization of mononuclear phagocyte subpopulations in the human lung by using monoclonal antibodies: changes in alveolar macrophage phenotype associated with pulmonary sarcoidosis. Journal of immunology (Baltimore, Md. : 1950). 1985 Academic Article GET IT
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Enhanced alveolar macrophage-mediated antigen-induced T-lymphocyte proliferation in sarcoidosis. The Journal of clinical investigation. 1985 Academic Article GET IT
Experimental polymyxin B-induced interstitial lung disease characterized by an accumulation of cytotoxic eosinophils in the alveolar structures. The American review of respiratory disease. 1985 Academic Article GET IT
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Motheaten mice--an animal model with an inherited form of interstitial lung disease. The American review of respiratory disease. 1985 Academic Article GET IT
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Pulmonary sarcoidosis: pathogenesis, staging and therapy. International archives of allergy and applied immunology. 1985 Academic Article GET IT
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Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis. Nature. 1985 Academic Article GET IT
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Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1. The Journal of clinical investigation. 1984 Academic Article GET IT
Accurate quantification of cells recovered by bronchoalveolar lavage. The American review of respiratory disease. 1984 Academic Article GET IT
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Alveolar macrophages in idiopathic pulmonary fibrosis have glucocorticoid receptors, but glucocorticoid therapy does not suppress alveolar macrophage release of fibronectin and alveolar macrophage derived growth factor. The American review of respiratory disease. 1984 Academic Article GET IT
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Natural killer cells are present in the normal human lung but are functionally impotent. The Journal of clinical investigation. 1984 Academic Article GET IT
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Pathogenesis of the granulomatous lung diseases. The American review of respiratory disease. 1984 Review GET IT
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Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung. The Journal of clinical investigation. 1984 Academic Article GET IT
Development of elastic fibers of nuchal ligament, aorta, and lung of fetal and postnatal sheep: an ultrastructural and electron microscopic immunohistochemical study. The American journal of anatomy. 1984 Academic Article GET IT
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Role of pleural mesothelial cells in the production of the submesothelial connective tissue matrix of lung. The American review of respiratory disease. 1984 Academic Article GET IT
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Eosinophil-mediated injury to lung parenchymal cells and interstitial matrix. A possible role for eosinophils in chronic inflammatory disorders of the lower respiratory tract. The Journal of clinical investigation. 1984 Academic Article GET IT
Elastin mRNA levels during foetal development of sheep nuchal ligament and lung. Hybridization to complementary and cloned DNA. The Biochemical journal. 1984 Academic Article GET IT
Sheep elastin genes. Isolation and preliminary characterization of a 9.9-kilobase genomic clone. The Biochemical journal. 1984 Academic Article GET IT
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Lysosomal function in the degradation of defective collagen in cultured lung fibroblasts. Biochemistry. 1984 Academic Article GET IT
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Hereditary emphysema in the tight-skin mouse. Evaluation of pathogenesis. The American review of respiratory disease. 1984 Academic Article GET IT
Importance of the lower respiratory tract in oxygen transfer. Exercise testing in patients with interstitial and destructive lung disease. The American review of respiratory disease. 1984 Academic Article GET IT
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Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract. The New England journal of medicine. 1984 Review GET IT
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Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract (first of two parts). The New England journal of medicine. 1984 Review GET IT
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Current concepts of the pathogenesis of fibrosis: lessons from pulmonary fibrosis. Progress in clinical and biological research. 1984 Review GET IT
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Paraquat-induced pulmonary fibrosis. Role of the alveolitis in modulating the development of fibrosis. The American review of respiratory disease. 1984 Academic Article GET IT
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Response of the lower respiratory tract to injury. Mechanisms of repair of the parenchymal cells of the alveolar wall. Chest. 1983 Review GET IT
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Role of fibronectin as a growth factor for fibroblasts. The Journal of cell biology. 1983 Academic Article GET IT
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Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers. The American review of respiratory disease. 1983 Academic Article GET IT
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Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders. The Journal of clinical investigation. 1983 Academic Article GET IT
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Ascorbate deficiency results in decreased collagen production: under-hydroxylation of proline leads to increased intracellular degradation. Archives of biochemistry and biophysics. 1983 Academic Article GET IT
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Pulmonary oxygen toxicity. Early reversible changes in human alveolar structures induced by hyperoxia. The New England journal of medicine. 1983 Academic Article GET IT
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Fibronectin mediates cell attachment to C1q: a mechanism for the localization of fibrosis in inflammatory disease. Clinical and experimental immunology. 1983 Academic Article GET IT
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The alveolitis of pulmonary sarcoidosis. Evaluation of natural history and alveolitis-dependent changes in lung function. The American review of respiratory disease. 1983 Academic Article GET IT
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The development of alveolar septa in fetal sheep lung. An ultrastructural and immunohistochemical study. The American journal of anatomy. 1983 Academic Article GET IT
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Fibroblasts: important producers and targets of inflammatory prostaglandins in the lungs. Chest. 1983 Academic Article GET IT
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Pulmonary oxygen toxicity. Bronchoalveolar lavage demonstration of early parameters of alveolitis. Chest. 1983 Academic Article GET IT
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Role of fibronectin in fibrotic lung disease. A growth factor for human lung fibroblasts. Chest. 1983 Academic Article GET IT
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Role of proteolytic and oxidative products of the neutrophil in determining the specificity of the pulmonary lesion in fibrotic and destructive lung disease. Chest. 1983 Academic Article GET IT
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Spontaneous release of interleukin-2 by lung T lymphocytes in active pulmonary sarcoidosis. The New England journal of medicine. 1983 Academic Article GET IT
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Hypersensitivity pneumonitis in man. Light- and electron-microscopic studies of 18 lung biopsies. The American journal of pathology. 1983 Academic Article GET IT
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Experience with replacement therapy in the destructive lung disease associated with severe alpha-1-antitrypsin deficiency. The American review of respiratory disease. 1983 Academic Article GET IT
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Effect of intermittent high dose parenteral corticosteroids on the alveolitis of idiopathic pulmonary fibrosis. The American review of respiratory disease. 1983 Academic Article GET IT
Regional localization of the human alpha 2(I) collagen gene on chromosome 7 by molecular hybridization. Cytogenetics and cell genetics. 1983 Academic Article GET IT
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Copy number of a human type I alpha 2 collagen gene. The Journal of biological chemistry. 1982 Academic Article GET IT
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Role of alveolar macrophages in asbestosis: modulation of neutrophil migration to the lung after acute asbestos exposure. Thorax. 1982 Academic Article GET IT
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Characterization of a signal peptide sequence in the cell-free translation product of sheep elastin mRNA. Archives of biochemistry and biophysics. 1982 Academic Article GET IT
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Human alveolar macrophage growth factor for fibroblasts. Regulation and partial characterization. The Journal of clinical investigation. 1982 Academic Article GET IT
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The collagen alpha-2 chain gene. The Journal of investigative dermatology. 1982 Academic Article GET IT
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The molecular aspects of elastin gene expression. The Journal of investigative dermatology. 1982 Academic Article GET IT
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Modulation of collagen production by fibroblasts. Effects of chronic exposure to agonists that increase intracellular cyclic AMP. The Biochemical journal. 1982 Academic Article GET IT
Interstitial lung disease: aggressive clinical management versus diagnostic and therapeutic nihilism. The Western journal of medicine. 1982 Academic Article GET IT
Regulation of elastin synthesis in developing sheep nuchal ligament by elastin mRNA levels. The Journal of biological chemistry. 1982 Academic Article GET IT
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Alveolitis: the key to the interstitial lung disorders. Thorax. 1982 Review GET IT
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Fibronectin in human bronchopulmonary lavage fluid. Elevation in patients with interstitial lung disease. The Journal of clinical investigation. 1982 Academic Article GET IT
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Lung inflammation in sarcoidosis: comparison of serum angiotensin-converting enzyme levels with bronchoalveolar lavage and gallium-67 scanning assessment of the T lymphocyte alveolitis. Thorax. 1982 Academic Article GET IT
Structure of alveolar epithelial cells in patients with fibrotic lung disorders. Laboratory investigation; a journal of technical methods and pathology. 1982 Academic Article GET IT
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Modulation of tropoelastin production and elastin messenger ribonucleic acid activity in developing sheep lung. Biochemistry. 1981 Academic Article GET IT
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Oxidant injury of lung parenchymal cells. The Journal of clinical investigation. 1981 Academic Article GET IT
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Production of fibronectin by the human alveolar macrophage: mechanism for the recruitment of fibroblasts to sites of tissue injury in interstitial lung diseases. Proceedings of the National Academy of Sciences of the United States of America. 1981 Academic Article GET IT
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Replacement therapy of alpha 1-antitrypsin deficiency. Reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects. The Journal of clinical investigation. 1981 Academic Article GET IT
Times cited: 211
Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema. The Journal of clinical investigation. 1981 Academic Article GET IT
Procollagen messenger RNA levels and activity and collagen synthesis during the fetal development of sheep lung, tendon, and skin. The Journal of biological chemistry. 1981 Academic Article GET IT
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Environmental lung disease and the interstitium. Clinics in chest medicine. 1981 Review GET IT
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Safety of fiberoptic bronchoalveolar lavage in evaluation of interstitial lung disease. Chest. 1981 Academic Article GET IT
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Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. The New England journal of medicine. 1981 Academic Article GET IT
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Asbestos stimulates alveolar macrophages to release a factor causing human lung fibroblasts to replicate. Chest. 1981 Academic Article GET IT
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Inflammation and asbestosis: characterization and maintenance of alveolitis following acute asbestos exposure. Chest. 1981 Academic Article GET IT
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Mechanisms of neutrophil accumulation in the lungs of patients with idiopathic pulmonary fibrosis. The Journal of clinical investigation. 1981 Academic Article GET IT
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Pulmonary asbestosis and idiopathic pulmonary fibrosis: pathogenetic parallels. Chest. 1981 Academic Article GET IT
Pulmonary connective tissue and environmental lung disease. Chest. 1981 Academic Article GET IT
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Hereditary emphysema in the tight-skin (Tsk/+) mouse. The American review of respiratory disease. 1981 Academic Article GET IT
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Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema. Science (New York, N.Y.). 1981 Academic Article GET IT
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Regulation of collagen production by the beta-adrenergic system. The Journal of clinical investigation. 1981 Academic Article GET IT
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Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease. The American review of respiratory disease. 1981 Academic Article GET IT
Times cited: 168
Gallium-67 scanning to stage the alveolitis of sarcoidosis: correlation with clinical studies, pulmonary function studies, and bronchoalveolar lavage. The American review of respiratory disease. 1981 Academic Article GET IT
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Procollagen production and procollagen messenger RNA levels and activity in human lung fibroblasts during periods of rapid and stationary growth. The Journal of biological chemistry. 1981 Academic Article GET IT
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Interstitial lung disease: current concepts of pathogenesis, staging and therapy. The American journal of medicine. 1981 Review GET IT
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Pulmonary Langerhans' cells in patients with fibrotic lung disorders. Laboratory investigation; a journal of technical methods and pathology. 1981 Academic Article GET IT
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Developmental regulation of elastin synthesis. Connective tissue research. 1981 Academic Article GET IT
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Mechanisms of hypergammaglobulinemia in pulmonary sarcoidosis. Site of increased antibody production and role of T lymphocytes. The Journal of clinical investigation. 1981 Academic Article GET IT
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Clinical significance of pulmonary function tests. Pulmonary function testing in interstitial pulmonary disease. What does it tell us?. Chest. 1980 Academic Article GET IT
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Functional correlates of lung involvement in Wegener's granulomatosis. Use of pulmonary function tests in staging and follow-up. The American journal of medicine. 1980 Academic Article GET IT
Human alveolar macrophage-derived chemotactic factor for neutrophils. Stimuli and partial characterization. The Journal of clinical investigation. 1980 Academic Article GET IT
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Human neutrophil elastase functions as a type III collagen "collagenase". Biochemical and biophysical research communications. 1980 Academic Article GET IT
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Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors. Nucleic acids research. 1980 Academic Article GET IT
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Collagen concentration and rates of synthesis in idiopathic pulmonary fibrosis. The American review of respiratory disease. 1980 Academic Article GET IT
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Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. Proceedings of the National Academy of Sciences of the United States of America. 1980 Academic Article GET IT
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Danazol-induced augmentation of serum alpha 1-antitrypsin levels in individuals with marked deficiency of this antiprotease. The Journal of clinical investigation. 1980 Academic Article GET IT
Subplasmalemmal linear densities in cells of the mononuclear phagocyte system in lung. The American journal of pathology. 1980 Academic Article GET IT
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Control of collagen production by human diploid lung fibroblasts. The Journal of biological chemistry. 1980 Academic Article GET IT
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Chronic airflow obstruction in Fabry's disease. The American journal of medicine. 1980 Academic Article GET IT
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Structural organization of a 17 KB segment of the alpha 2 collagen gene: evaluation by R loop mapping. Nucleic acids research. 1980 Academic Article GET IT
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Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen. The Journal of biological chemistry. 1980 Academic Article GET IT
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Isolation and characterization of a 15-kilobase genomic sequence coding for part of the Pro alpha 2 chain of sheep type I collagen. The Journal of biological chemistry. 1980 Academic Article GET IT
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Regulation of the release of alveolar macrophage-derived neutrophil chemotactic factor. The American review of respiratory disease. 1980 Academic Article GET IT
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Maintenance of granuloma formation in pulmonary sarcoidosis by T lymphocytes within the lung. The New England journal of medicine. 1980 Academic Article GET IT
Radionuclide cinepneumography: flow-volume imaging of the respiratory cycle. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1980 Academic Article GET IT
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Danazol-induced elevation of serum alpha 1-antitrypsin in individuals with severe deficiency of this antiprotease. Chest. 1980 Academic Article GET IT
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Mechanism by which cigarette smoke attracts polymorphonuclear leukocytes to lung. Chest. 1980 Academic Article GET IT
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Evaluation of the protease-antiprotease theory of human destructive lung disease. Bulletin europeen de physiopathologie respiratoire. 1980 Academic Article GET IT
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Opportunities for the specific therapy of destructive lung disease. Bulletin europeen de physiopathologie respiratoire. 1980 Academic Article GET IT
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The tight-skin mouse: an animal model of inherited emphysema. Bulletin europeen de physiopathologie respiratoire. 1980 Academic Article GET IT
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Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans. Science (New York, N.Y.). 1979 Academic Article GET IT
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Flexible fiberoptic bronchoscopy of the rhesus monkey (Macaca mulatta). Laboratory animal science. 1979 Academic Article GET IT
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Acute hypersensitivity pneumonitis: serial changes in lung lymphocyte subopulations after exposure to antigen. The American review of respiratory disease. 1979 Academic Article GET IT
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Collagenase in the lower respiratory tract of patients with idiopathic pulmonary fibrosis. The New England journal of medicine. 1979 Academic Article GET IT
Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. The American review of respiratory disease. 1979 Academic Article GET IT
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Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. The American journal of pathology. 1979 Academic Article GET IT
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Anchoring fibrils in the normal canine respiratory system. The American review of respiratory disease. 1979 Academic Article GET IT
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Localization of the immune response in sarcoidosis. The American review of respiratory disease. 1979 Academic Article GET IT
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Ultrastructure of pulmonary mast cells in patients with fibrotic lung disorders. Laboratory investigation; a journal of technical methods and pathology. 1979 Academic Article GET IT
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Synthesis and degradation of collagen by skin fibroblasts from controls and from patients with osteogenesis imperfecta. FEBS letters. 1979 Academic Article GET IT
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Procollagen alpha2 mRNA is significantly different from procollagen alpha1(I) mRNA in size or secondary structure. Biochemical and biophysical research communications. 1979 Academic Article GET IT
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Morphologic-physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis. The Journal of clinical investigation. 1979 Academic Article GET IT
Times cited: 168
Destruction of a major extracellular adhesive glycoprotein (fibronectin) of human fibroblasts by neutral proteases from polymorphonuclear leukocyte granules. Laboratory investigation; a journal of technical methods and pathology. 1979 Academic Article GET IT
Times cited: 79
Comparison of the alveolitis of sarcoidosis and idiopathic pulmonary fibrosis. Chest. 1979 Academic Article GET IT
Times cited: 9
Nuclear inclusions in alveolar epithelium of patients with fibrotic lung disorders. The American journal of pathology. 1979 Academic Article GET IT
Times cited: 26
Pathogenetic studies in idiopathic pulmonary fibrosis. Control of neutrophil migration by immune complexes. Chest. 1979 Academic Article GET IT
Times cited: 10
Bronchoalveolar lavage in interstitial lung disease. Annals of internal medicine. 1978 Academic Article GET IT
Anchoring fibrils. A new connective tissue structure in fibrotic lung disease. The American journal of pathology. 1978 Academic Article GET IT
Times cited: 25
Gallium-67 citrate scanning in the staging of idiopathic pulmonary fibrosis: Correlation and physiologic and morphologic features and bronchoalveolar lavage. The American review of respiratory disease. 1978 Academic Article GET IT
Times cited: 100
Distribution of HLA antigens in idiopathic pulmonary fibrosis. The American review of respiratory disease. 1978 Academic Article GET IT
Times cited: 23
Degradation of newly synthesized collagen. The Journal of biological chemistry. 1978 Academic Article GET IT
Times cited: 179
Association in normal human fibroblasts of elevated levels of adenosine 3':5'-monophosphate with a selective decrease in collagen production. The Journal of biological chemistry. 1978 Academic Article GET IT
Times cited: 78
Cells, collagen and idiopathic pulmonary fibrosis. Lung. 1978 Academic Article GET IT
Times cited: 47
Metabolic fate of the major cell surface protein of normal human fibroblasts. Biochemical and biophysical research communications. 1977 Academic Article GET IT
Times cited: 46
Small airways in idiopathic pulmonary fibrosis. Comparison of morphologic and physiologic observations. The Journal of clinical investigation. 1977 Academic Article GET IT
Times cited: 101
Granulocyte collagenase: selective digestion of type I relative to type III collagen. Proceedings of the National Academy of Sciences of the United States of America. 1977 Academic Article GET IT
Times cited: 154
Thermodynamic resolution of the iron-sulfur centers of the succinic dehydrogenase of Rhodopseudomonas sphaeroides. Archives of biochemistry and biophysics. 1977 Academic Article GET IT
Times cited: 30
Alveolar multiplication in the contralateral lung after unilateral pneumonectomy in the rabbit. The American review of respiratory disease. 1977 Academic Article GET IT
Times cited: 44
Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. The Journal of clinical investigation. 1977 Academic Article GET IT
Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell. Nature. 1976 Academic Article GET IT
Times cited: 45
Idiopathic pulmonary fibrosis. Clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects. Annals of internal medicine. 1976 Review GET IT
Pathogenic mechanisms in pulmonary fibrosis: collagen-induced migration inhibition factor production and cytotoxicity mediated by lymphocytes. The Journal of clinical investigation. 1976 Academic Article GET IT
Collagenase from rabbit pulmonary alveolar macrophages. Biochemical and biophysical research communications. 1976 Academic Article GET IT
Times cited: 44
Biochemical approaches to the investigation of fibrotic lung disease. Chest. 1976 Academic Article GET IT
Times cited: 8
Diffuse fibrotic lung disease: a correlative study. Chest. 1976 Academic Article GET IT
Times cited: 12
Lung collagen heterogeneity. Synthesis of type I and type III collagen by rabbit and human lung cells in culture. The Journal of clinical investigation. 1976 Academic Article GET IT
Times cited: 44
Content and synthesis of glycosaminoglycans in the developing lung. The Journal of clinical investigation. 1975 Academic Article GET IT
Times cited: 45
The connective tissue of lung. The American review of respiratory disease. 1975 Review GET IT
Times cited: 160
Characterization of cell-free synthesis of collagen by lung polysomes in a heterologous system. The Journal of biological chemistry. 1975 Academic Article GET IT
Times cited: 15
Collagen in the human lung. Quantitation of rates of synthesis and partial characterization of composition. The Journal of clinical investigation. 1975 Academic Article GET IT
Times cited: 58
Lung growth after unilateral pneumonectomy: quantitation of collagen synthesis and content. The American review of respiratory disease. 1975 Academic Article GET IT
Times cited: 54
Collagen in the lung: development of a technology applicable to human lung disease. Chest. 1975 Academic Article GET IT
Times cited: 2
Lung collagen: definition, diversity and development. Federation proceedings. 1974 Review GET IT
Times cited: 27
Lung collagen heterogeneity. Proceedings of the National Academy of Sciences of the United States of America. 1974 Academic Article GET IT
Times cited: 36
Lung collagen composition and synthesis. Characterization and changes with age. The Journal of biological chemistry. 1974 Academic Article GET IT
Times cited: 118
Initiation of globin synthesis: assays. Methods in enzymology. 1974 Academic Article GET IT
Times cited: 63
Paper electrophoresis and chromatography of oligopeptides with N-terminal methionine. Analytical biochemistry. 1973 Academic Article GET IT
Times cited: 6
Initiation of globin synthesis in beta-thalassemia. The New England journal of medicine. 1973 Academic Article GET IT
Times cited: 10
Isolation of protein synthesis initiation factors from rabbit liver. The Journal of biological chemistry. 1973 Academic Article GET IT
Times cited: 41
Initiation of globin synthesis. Preparation and use of reticulocyte ribosomes retaining initiation region messenger ribonucleic acid fragments. The Journal of biological chemistry. 1972 Academic Article GET IT
Times cited: 27
Initiation of globin synthesis. FEBS letters. 1972 Academic Article GET IT
Initiation of hemoglobin synthesis: comparison of model reactions that use artificial templates with those using natural messenger RNA. Proceedings of the National Academy of Sciences of the United States of America. 1972 Academic Article GET IT
Times cited: 24
Requirement for GTP in the initiation process on reticulocyte ribosomes and ribosomal subunits. Proceedings of the National Academy of Sciences of the United States of America. 1971 Academic Article GET IT
Times cited: 34
Initial dipeptide formation in hemoglobin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 1971 Academic Article GET IT
Times cited: 33
Effects of nephrectomy and ureteral occlusion on extracellular fluid measurements during shock. Surgery, gynecology & obstetrics. 1970 Academic Article GET IT
Times cited: 3
Cushing's syndrome caused by a metyrapone responsive adrenocortical adenoma. The Journal of clinical endocrinology and metabolism. 1970 Academic Article GET IT
Times cited: 8
Kinetics of monovalent and divalent anion distribution in hemorrhagic hypotension and hypoxemia. Annals of surgery. 1969 Academic Article GET IT
Times cited: 2
Influence of hemorrhagic hypotension on measurements of the extracellular fluid volume. Surgery, gynecology & obstetrics. 1969 Academic Article GET IT
Times cited: 18

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Research

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Co-investigator Network

Funding awarded

Ancillary SOURCE Study: Characterization of Small Airway Basal Cell Biology in Early COPD awarded by National Heart, Lung, & Blood Institute Principal Investigator 2023 - 2027
MSA between Forge Biologics and Weill Cornell awarded by Forge Biologics Principal Investigator 2022 - 2027
MSA between UMASS and Weill Cornell University awarded by University of Massachusetts Principal Investigator 2022 - 2027
MSA between ENYX Therapeutics LLC and Weill Cornell awarded by ENYX Therapeutics, LLC Principal Investigator 2022 - 2027
MSA between Weill Cornell and Bionic Sight awarded by Bionic Sight Principal Investigator 2022 - 2025
MSA between Weill Cornell and LEXEO Therapeutics LLC awarded by LEXEO Therapeutics, Inc. Principal Investigator 2021 - 2025
missing activity Principal Investigator 2021 - 2024
Manufacturing Services Agreement between PTC and WCM awarded by PTC Therapeutics Principal Investigator 2019 - 2024
Xylocor Master Services Agreement for AdVEGF-All6A+ awarded by XyloCor Principal Investigator 2019 - 2023
Phase IA/IB Study of AAVrh.10hFXN Therapy to Treat the Cardiomyopathy of Friedreich''s Ataxia awarded by National Heart, Lung, & Blood Institute Principal Investigator 2020 - 2022
Clinical Assessment of Anti-cocaine Vaccine dAdGNE in Cocaine Addicts awarded by National Institute on Drug Abuse Principal Investigator 2019 - 2022
missing activity Principal Investigator 2018 - 2022
missing activity Principal Investigator 2021 - 2021
missing activity Principal Investigator 2019 - 2021
missing activity Principal Investigator 2019 - 2021

Understanding the Origins of Early COPD awarded by National Heart, Lung, & Blood Institute Co-Investigator 2020 - 2025
missing activity Co-Investigator 2020 - 2022
missing activity Co-Investigator 2017 - 2021

New PET/CT System for Human and Non-human Primate Imaging awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2024
MSA with University of Pittsburgh and Cornell awarded by Health Resources & Services Administration Key Personnel 2020 - 2024
Major Cyclotron Upgrades and Refurbishment awarded by National Institutes of Health, Office of the Director Key Personnel 2021 - 2022
AAV-Based Gene Therapy for the Long-Term Treatment of CLN2-Associated Retinal Degeneration and Prevention of Blindness in CLN2 Patients awarded by Daedalus Fund for Innovation (Weill Cornell) Key Personnel 2021 - 2022
missing activity Key Personnel 2021 - 2022
missing activity Key Personnel 2021 - 2022
Rapid Noninvasive Whole-body Imaging of AAV Gene Transfer Vectors awarded by National Institute of Biomedical Imaging & Bioengineering Key Personnel 2019 - 2022

Precision Pharmacogenomics in Qatar awarded by Qatar National Research Fund Principal Investigator Subaward 2020 - 2022

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Background

education and training

M.D., University of Pennsylvania School of Medicine 1968
M.S., University of Pennsylvania 1963
B.A., Tufts University 1962

Contact

full name

Ronald G Crystal

primary email

rgcryst@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Ronald G Crystal Chair of Genetic Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage