Kolesnick, Richard

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selected publications

A rectal cancer organoid platform to study individual responses to chemoradiation. Nature medicine. 2019 Academic Article GET IT
Times cited: 239
Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation. Cellular signalling. 2017 Academic Article GET IT
Times cited: 13
Distinct Levels of Radioresistance in Lgr5⁺ Colonic Epithelial Stem Cells versus Lgr5⁺ Small Intestinal Stem Cells. Cancer research. 2017 Academic Article GET IT
Times cited: 36
Targeting acid sphingomyelinase with anti-angiogenic chemotherapy. Cellular signalling. 2016 Academic Article GET IT
Times cited: 15
Establishing estrogen-responsive mouse mammary organoids from single Lgr5⁺ cells. Cellular signalling. 2016 Academic Article GET IT
Times cited: 30
Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart. Journal of molecular and cellular cardiology. 2016 Academic Article GET IT
Times cited: 32
Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors. PloS one. 2016 Article GET IT
Times cited: 11
Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation. PloS one. 2015 Article GET IT
Times cited: 121
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015 Academic Article GET IT
Times cited: 657
Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis. Biochimica et biophysica acta. 2015 Academic Article GET IT
Times cited: 20
Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors. PloS one. 2015 Academic Article GET IT
Times cited: 11
Caenorhabditis elegans as a model to study sphingolipid signaling. Biological chemistry. 2015 Review GET IT
Times cited: 4
The life and work of Dr. Robert Bittman (1942-2014). Biological chemistry. 2015 Academic Article GET IT
Axitinib sensitization of high Single Dose Radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2014 Academic Article GET IT
Times cited: 37
Kinase suppressor of Ras signals through Thr269 of c-Raf-1. The Journal of biological chemistry. 2013 Article GET IT
The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK. The Journal of biological chemistry. 2013 Article GET IT
Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PloS one. 2013 Academic Article GET IT
Times cited: 20
Acid sphingomyelinase. Handbook of experimental pharmacology. 2013 Review GET IT
Times cited: 64
Using ASMase knockout mice to model human diseases. Handbook of experimental pharmacology. 2013 Review GET IT
Times cited: 14
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity. 2012 Academic Article GET IT
Times cited: 444
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology. 2012 Academic Article GET IT
Times cited: 167
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 101
Accelerated hematopoietic toxicity by high energy (56)Fe radiation. International journal of radiation biology. 2011 Academic Article GET IT
Times cited: 33
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 271
The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes. 2011 Academic Article GET IT
Times cited: 73
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PloS one. 2011 Academic Article GET IT
Times cited: 121
Alpha particles induce apoptosis through the sphingomyelin pathway. Radiation research. 2011 Academic Article GET IT
Times cited: 24
Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. Cancer research. 2010 Academic Article GET IT
Times cited: 68
Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited. Cancer research. 2010 Academic Article GET IT
Times cited: 51
Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PloS one. 2010 Academic Article GET IT
Times cited: 100
Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. PloS one. 2010 Academic Article GET IT
Times cited: 100
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cellular signalling. 2010 Academic Article GET IT
Times cited: 174
Ceramide-rich platforms in transmembrane signaling. FEBS letters. 2010 Review GET IT
Times cited: 207
Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer research. 2010 Academic Article GET IT
Times cited: 23
Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients. Blood. 2010 Letter GET IT
Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochemical and biophysical research communications. 2009 Academic Article GET IT
Times cited: 18
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Academic Article GET IT
Times cited: 20
A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2009 Academic Article GET IT
Times cited: 39
RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance. Expert reviews in molecular medicine. 2009 Review GET IT
Times cited: 7
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. Cancer biology & therapy. 2009 Academic Article GET IT
Times cited: 18
Timing of lethality from gastrointestinal syndrome in mice revisited. International journal of radiation oncology, biology, physics. 2009 Editorial Article GET IT
Times cited: 33
Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 155
Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer biology & therapy. 2008 Academic Article GET IT
Times cited: 13
Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 25
Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. International journal of radiation oncology, biology, physics. 2008 Academic Article GET IT
Times cited: 55
Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS letters. 2007 Academic Article GET IT
Times cited: 66
Sphingolipids and cell death. Apoptosis : an international journal on programmed cell death. 2007 Review GET IT
Times cited: 192
Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations. Mitochondrion. 2006 Academic Article GET IT
Times cited: 192
Multiple trichoepitheliomas in the lines of Blaschko. 2006 GET IT
Times cited: 14
ATM regulates target switching to escalating doses of radiation in the intestines. Nature medicine. 2005 Academic Article GET IT
Times cited: 123
Caspase-dependent and -independent activation of acid sphingomyelinase signaling. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 141
Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 49
A central role for ceramide in the age-related acceleration of apoptosis in the female germline. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Academic Article GET IT
Times cited: 91
Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiation research. 2004 Academic Article GET IT
Times cited: 218
Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer research. 2004 Academic Article GET IT
Times cited: 33
Inflammatory bowel disease reveals the kinase activity of KSR1. The Journal of clinical investigation. 2004 Comment GET IT
Times cited: 21
Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nature genetics. 2004 Academic Article GET IT
Times cited: 61
[The role of glucocorticoid hormones in interleukin-1 signal transduction via the sphingomyelin pathway]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2004 Academic Article GET IT
Times cited: 1
The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 13
Ceramide synthesis and metabolism as a target for cancer therapy. Cancer letters. 2004 Review GET IT
Times cited: 295
Raft ceramide in molecular medicine. Oncogene. 2003 Review GET IT
Times cited: 357
Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Nature medicine. 2003 Academic Article GET IT
Times cited: 52
Radiation and ceramide-induced apoptosis. Oncogene. 2003 Review GET IT
Times cited: 412
Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene. 2003 Academic Article GET IT
Times cited: 237
Microvascular function regulates intestinal crypt response to radiation. Cancer research. 2003 Academic Article GET IT
Times cited: 109
Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer research. 2003 Academic Article GET IT
Times cited: 103
Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 104
Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 1350
Realizing the promise of apoptosis-based therapies: separating the living from the clinically undead. Cell death and differentiation. 2003 Article GET IT
Times cited: 17
Sphingolipids as therapeutics. Pharmacological research. 2003 Review GET IT
Times cited: 67
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nature medicine. 2003 Academic Article GET IT
Times cited: 469
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology. 2003 Academic Article GET IT
Times cited: 58
CD95 rapidly clusters in cells of diverse origins. Cancer biology & therapy. 2003 Academic Article GET IT
Times cited: 51
Ceramide and sphingosine 1-phosphate in anti-cancer therapies. Cancer treatment and research. 2003 Review GET IT
Times cited: 23
Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility. Biochimica et biophysica acta. 2002 Review GET IT
Times cited: 83
Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?. FEBS letters. 2002 Review GET IT
Times cited: 298
Sphingosine 1-phosphate as a therapeutic agent. Leukemia. 2002 Review GET IT
Times cited: 115
Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nature medicine. 2002 Letter GET IT
Times cited: 135
The therapeutic potential of modulating the ceramide/sphingomyelin pathway. The Journal of clinical investigation. 2002 Review GET IT
Times cited: 384
Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 302
Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer research. 2002 Academic Article GET IT
Times cited: 91
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics. 2002 Academic Article GET IT
Times cited: 93
Acid sphingomyelinase-derived ceramide signaling in apoptosis. Sub-cellular biochemistry. 2002 Review GET IT
Times cited: 63
jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. The EMBO journal. 2001 Academic Article GET IT
Times cited: 50
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science (New York, N.Y.). 2001 Academic Article GET IT
Times cited: 1061
Ceramide enables fas to cap and kill. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 337
CD95 signaling via ceramide-rich membrane rafts. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 537
Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 85
Analysis of sphingomyelin and ceramide levels and the enzymes regulating their metabolism in response to cell stress. Methods in cell biology. 2001 Academic Article GET IT
Times cited: 25
Niemann-Pick Disease versus acid sphingomyelinase deficiency. Cell death and differentiation. 2001 Letter GET IT
Times cited: 26
Kinase suppressor of Ras signals through Thr269 of c-Raf-1. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 63
Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 106
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nature medicine. 2000 Academic Article GET IT
Times cited: 516
CD95-mediated apoptosis in vivo involves acid sphingomyelinase. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 134
Compartmentalization of ceramide signaling: physical foundations and biological effects. Journal of cellular physiology. 2000 Review GET IT
Times cited: 382
Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 31
Ceramide mediates radiation-induced death of endothelium. Critical care medicine. 2000 Review GET IT
Times cited: 50
CD95(Fas/APO-1) signals ceramide generation independent of the effector stage of apoptosis. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 78
Role of acidic sphingomyelinase in Fas/CD95-mediated cell death. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 126
Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency. Cancer research. 2000 Academic Article GET IT
Times cited: 317
Measurement of ceramide levels by the diacylglycerol kinase reaction and by high-performance liquid chromatography-fluorescence spectrometry. Methods in enzymology. 2000 Academic Article GET IT
Times cited: 21
Measurement of ceramide synthase activity. Methods in enzymology. 2000 Academic Article GET IT
Times cited: 9
Measurement of sphingomyelinase activity. Methods in enzymology. 2000 Academic Article GET IT
Times cited: 24
Sphingolipid signaling in gonadal development and function. Chemistry and physics of lipids. 1999 Review GET IT
Times cited: 19
Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase. Cancer research. 1999 Academic Article GET IT
Times cited: 83
Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 102
Stress signals for apoptosis: ceramide and c-Jun kinase. Oncogene. 1998 Review GET IT
Times cited: 200
BAD enables ceramide to signal apoptosis via Ras and Raf-1. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 159
Signal transduction of stress via ceramide. The Biochemical journal. 1998 Review GET IT
Times cited: 621
Ceramide generation by the Reaper protein is not blocked by the caspase inhibitor, p35. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 46
Normal development, oncogenesis and programmed cell death. Oncogene. 1998 Conference Paper GET IT
Times cited: 6
Caenorhabditis elegans contains two distinct acid sphingomyelinases. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 32
12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. Cancer research. 1998 Academic Article GET IT
Times cited: 153
Regulation of ceramide production and apoptosis. Annual review of physiology. 1998 Review GET IT
Times cited: 733
Signaling in and regulation of ionizing radiation-induced apoptosis in endothelial cells. Recent progress in hormone research. 1998 Review GET IT
Times cited: 45
Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. The Journal of experimental medicine. 1997 Academic Article GET IT
Times cited: 384
Kinase suppressor of Ras is ceramide-activated protein kinase. Cell. 1997 Academic Article GET IT
Times cited: 393
Stress-induced apoptosis and the sphingomyelin pathway. Biochemical pharmacology. 1997 Review GET IT
Times cited: 221
Ceramide signaling in apoptosis. British medical bulletin. 1997 Review GET IT
Times cited: 181
Differential inhibition of radiation-induced apoptosis. Stem cells (Dayton, Ohio). 1997 Review GET IT
Times cited: 20
Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 29
Modulation of the Apoptotic Response: Potential for Improving the Outcome in Clinical Radiotherapy. Seminars in radiation oncology. 1996 Academic Article GET IT
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell. 1996 Academic Article GET IT
Times cited: 730
Fas-mediated apoptosis and sphingomyelinase signal transduction: the role of ceramide as a second messenger for apoptosis. Cell death and differentiation. 1996 Academic Article GET IT
Signal transduction through lipid second messengers. Current opinion in cell biology. 1996 Review GET IT
Times cited: 474
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 1996 Academic Article GET IT
Times cited: 1718
Ceramide and the induction of apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. 1996 Review GET IT
Times cited: 125
Phosphorylation of Raf by ceramide-activated protein kinase. Nature. 1995 Academic Article GET IT
Times cited: 303
Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis. The EMBO journal. 1995 Academic Article GET IT
Times cited: 241
Inhibition of ceramide-induced apoptosis by Bcl-2. Cell death and differentiation. 1995 Academic Article GET IT
Signaling through the sphingomyelin pathway. Endocrinology. 1995 Editorial Article GET IT
Times cited: 62
Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 1995 Academic Article GET IT
Times cited: 787
Ceramide: a signal for apoptosis or mitogenesis?. The Journal of experimental medicine. 1995 Comment GET IT
Times cited: 157
Does endotoxin stimulate cells by mimicking ceramide?. Immunology today. 1995 Review GET IT
Times cited: 88
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity. 1995 Academic Article GET IT
Times cited: 433
The role of the sphingomyelin pathway and protein kinase C in radiation-induced cell kill. Important advances in oncology. 1995 Review GET IT
Times cited: 24
Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 178
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. The Journal of experimental medicine. 1994 Academic Article GET IT
Times cited: 856
Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 133
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell. 1994 Review GET IT
Times cited: 916
Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells. Blood. 1994 Academic Article GET IT
Times cited: 36
Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 201
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 484
Signal transduction through the sphingomyelin pathway. Molecular and chemical neuropathology. 1994 Review GET IT
Times cited: 80
The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochemistry and cell biology = Biochimie et biologie cellulaire. 1994 Review GET IT
Times cited: 142
Retinoic acid stimulates the protein kinase C pathway before activation of its beta-nuclear receptor during human teratocarcinoma differentiation. Biochimica et biophysica acta. 1993 Academic Article GET IT
Times cited: 25
Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 110
Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 166
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 254
Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta. Science (New York, N.Y.). 1993 Academic Article GET IT
Times cited: 391
Ceramide: a novel second messenger. Advances in lipid research. 1993 Review GET IT
Times cited: 88
A rise and fall in 1,2-diacylglycerol content signal hexamethylene bisacetamide-induced erythropoiesis. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 21
Ceramide: a novel second messenger. Trends in cell biology. 1992 Academic Article GET IT
Times cited: 91
A synthetic ceramide analog, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, selectively inhibits adherence during macrophage differentiation of human leukemia cells. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 29
Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system. Science (New York, N.Y.). 1992 Academic Article GET IT
Times cited: 372
Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 59
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 350
Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 124
Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 27
Sphingomyelin and derivatives as cellular signals. Progress in lipid research. 1991 Review GET IT
Times cited: 258
Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 119
Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 163
Physiologic 1,2-diacylglycerol levels induce protein kinase C-independent translocation of a regulatory enzyme. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 34
1,2-Diacylglycerols overcome cyclic AMP-mediated inhibition of phosphatidylcholine synthesis in GH3 pituitary cells. The Biochemical journal. 1990 Academic Article GET IT
Times cited: 15
Trifluoperazine stimulates the coordinate degradation of sphingomyelin and phosphatidylcholine in GH3 pituitary cells. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 10
Thyrotropin-releasing hormone and phorbol esters stimulate sphingomyelin synthesis in GH3 pituitary cells. Evidence for involvement of protein kinase C. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 14
Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 63
1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase. The Journal of biological chemistry. 1988 Academic Article GET IT
Times cited: 97
1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 162
Thyrotropin-releasing hormone and phorbol esters induce phosphatidylcholine synthesis in GH3 pituitary cells. Evidence for stimulation via protein kinase C. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 29
1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 78
Thyrotropin-releasing hormone stimulation of prolactin secretion is coordinately but not synergistically regulated by an elevation of cytoplasmic calcium and 1,2-diacylglycerol. Endocrinology. 1986 Academic Article GET IT
Times cited: 15
Thyrotropin-releasing hormone and the pituitary. New insights into the mechanism of stimulated secretion and clinical usage. The American journal of medicine. 1985 Review GET IT
Times cited: 18
Direct evidence that burst but not sustained secretion of prolactin stimulated by thyrotropin-releasing hormone is dependent on elevation of cytoplasmic calcium. The Journal of biological chemistry. 1985 Academic Article GET IT
Times cited: 16
Arachidonic acid inhibits thyrotropin-releasing hormone-induced elevation of cytoplasmic free calcium in GH3 pituitary cells. The Journal of biological chemistry. 1985 Academic Article GET IT
Times cited: 27
Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 44
Arachidonic acid mobilizes calcium and stimulates prolactin secretion from GH3 cells. The American journal of physiology. 1984 Academic Article GET IT
Times cited: 77
Thyrotropin (TSH)-releasing hormone decreases phosphatidylinositol and increases unesterified arachidonic acid in thyrotropic cells: possible early events in stimulation of TSH secretion. Endocrinology. 1984 Academic Article GET IT
Times cited: 32
Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion. The Journal of biological chemistry. 1983 Academic Article GET IT
Times cited: 115

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Background

education and training

M.D., University of Chicago Pritzker School of Medicine 1978
B.A., The Johns Hopkins University 1974

Contact

full name

Richard Kolesnick

primary email

rik2015@med.cornell.edu

VIVO Weill Cornell Medical College

Richard Kolesnick Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email