Does endotoxin stimulate cells by mimicking ceramide? Review uri icon

Overview

abstract

  • Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide. Bacterial endotoxin (lipopolysaccharide; LPS) shows strong structural and functional resemblance to ceramide. Here, Samuel Wright and Richard Kolesnick review data suggesting that LPS may provoke cellular responses by mimicking the action of ceramide.

publication date

  • June 1, 1995

Research

keywords

  • Acute-Phase Proteins
  • Ceramides
  • Endotoxins
  • Membrane Glycoproteins
  • Molecular Mimicry

Identity

Scopus Document Identifier

  • 0029023368

Digital Object Identifier (DOI)

  • 10.1016/0167-5699(95)80185-5

PubMed ID

  • 7544978

Additional Document Info

volume

  • 16

issue

  • 6