Blanchard, Scott C.

Publications

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selected publications

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles. bioRxiv : the preprint server for biology. 2020 Article GET IT
Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 22
Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands. Journal of virology. 2020 Academic Article GET IT
Times cited: 15
Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles. Nature structural & molecular biology. 2020 Academic Article GET IT
Times cited: 32
Single-molecule transport kinetics of a glutamate transporter homolog shows static disorder. Science advances. 2020 Academic Article GET IT
Times cited: 15
Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins. Journal of virology. 2020 Academic Article GET IT
Times cited: 17
Author Correction: Quantifying secondary transport at single-molecule resolution. Nature. 2020 Academic Article GET IT
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature communications. 2020 Academic Article GET IT
Times cited: 22
Elongation Factor Tu Switch I Element is a Gate for Aminoacyl-tRNA Selection. Journal of molecular biology. 2020 Academic Article GET IT
Times cited: 8
Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 23
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. Nature communications. 2020 Academic Article GET IT
Times cited: 26
Quantifying secondary transport at single-molecule resolution. Nature. 2019 Academic Article GET IT
Times cited: 29
Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin. Nature chemical biology. 2019 Academic Article GET IT
Times cited: 30
A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. eLife. 2019 Academic Article GET IT
Times cited: 68
Correction to: Implications of sequence variation on the evolution of rRNA. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 2019 Article GET IT
The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 18
Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor. eLife. 2019 Academic Article GET IT
Times cited: 31
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease. Nature communications. 2019 Academic Article GET IT
Times cited: 94
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET. Nature. 2019 Academic Article GET IT
Times cited: 107
Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome. Nucleic acids research. 2019 Academic Article GET IT
Times cited: 13
ERASE: a novel surface reconditioning strategy for single-molecule experiments. Nucleic acids research. 2019 Academic Article GET IT
Times cited: 1
Implications of sequence variation on the evolution of rRNA. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 2019 Review GET IT
Times cited: 11
tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis. Cell reports. 2018 Academic Article GET IT
Times cited: 35
ADAM10 controls the differentiation of the coronary arterial endothelium. Angiogenesis. 2018 Academic Article GET IT
Times cited: 25
Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype. Cell reports. 2018 Academic Article GET IT
Times cited: 55
A facile approach for the in vitro assembly of multimeric membrane transport proteins. eLife. 2018 Academic Article GET IT
Times cited: 15
A Much-Needed Boost for the Dwindling Antibiotic Pipeline. Molecular cell. 2018 Comment GET IT
Times cited: 6
HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. eLife. 2018 Academic Article GET IT
Times cited: 87
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression. Science advances. 2018 Academic Article GET IT
Times cited: 120
A partially-open inward-facing intermediate conformation of LeuT is associated with Na⁺ release and substrate transport. Nature communications. 2018 Academic Article GET IT
Times cited: 31
Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions. Nature communications. 2018 Academic Article GET IT
Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 106
Dynamics of P-type ATPase transport revealed by single-molecule FRET. Nature. 2017 Academic Article GET IT
Times cited: 52
The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions. Nature communications. 2017 Academic Article GET IT
Times cited: 57
Miscoding-induced stalling of substrate translocation on the bacterial ribosome. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 23
Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate. Journal of the American Chemical Society. 2017 Academic Article GET IT
Times cited: 27
Single-molecule analysis of ligand efficacy in β₂AR-G-protein activation. Nature. 2017 Academic Article GET IT
Times cited: 200
Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins. mBio. 2016 Academic Article GET IT
Times cited: 95
Effect of acidic pH on the stability of α-synuclein dimers. Biopolymers. 2016 Academic Article GET IT
Times cited: 24
Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging. Chemical science. 2016 Academic Article GET IT
Times cited: 39
Engineering a Prototypic P-type ATPase Listeria monocytogenes Ca(2+)-ATPase 1 for Single-Molecule FRET Studies. Bioconjugate chemistry. 2016 Academic Article GET IT
Times cited: 8
Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I. PLoS genetics. 2016 Academic Article GET IT
Times cited: 21
Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 26
Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 36
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. Science (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 235
Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation. Nature structural & molecular biology. 2016 Academic Article GET IT
Times cited: 84
Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale. Nature methods. 2016 Academic Article GET IT
Times cited: 142
Genome Sequence and Analysis of Escherichia coli MRE600, a Colicinogenic, Nonmotile Strain that Lacks RNase I and the Type I Methyltransferase, EcoKI. Genome biology and evolution. 2016 Academic Article GET IT
Times cited: 25
Intra-molecular triplet energy transfer is a general approach to improve organic fluorophore photostability. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2015 Academic Article GET IT
Times cited: 34
Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis. Molecular cell. 2015 Academic Article GET IT
Times cited: 46
Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. Nature communications. 2015 Academic Article GET IT
Times cited: 42
Assembly and diploid architecture of an individual human genome via single-molecule technologies. Nature methods. 2015 Academic Article GET IT
Times cited: 330
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nature structural & molecular biology. 2015 Academic Article GET IT
Times cited: 260
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Molecular cell. 2015 Academic Article GET IT
Times cited: 57
Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis. Biophysical journal. 2015 Academic Article GET IT
Times cited: 39
High-resolution structure of the Escherichia coli ribosome. Nature structural & molecular biology. 2015 Academic Article GET IT
Times cited: 159
Transport domain unlocking sets the uptake rate of an aspartate transporter. Nature. 2015 Academic Article GET IT
Times cited: 122
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 29
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions. Science (New York, N.Y.). 2014 Academic Article GET IT
Times cited: 350
Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014 Academic Article GET IT
Times cited: 577
Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 12
The bright future of single-molecule fluorescence imaging. Current opinion in chemical biology. 2014 Review GET IT
Times cited: 101
Ultra-stable organic fluorophores for single-molecule research. Chemical Society reviews. 2014 Review GET IT
Times cited: 262
The contribution of reactive oxygen species to the photobleaching of organic fluorophores. Photochemistry and photobiology. 2013 Academic Article GET IT
Times cited: 102
The central role of protein S12 in organizing the structure of the decoding site of the ribosome. RNA (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 26
Tuning a riboswitch response through structural extension of a pseudoknot. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 57
Transport dynamics in a glutamate transporter homologue. Nature. 2013 Academic Article GET IT
Times cited: 129
Small-molecule photostabilizing agents are modifiers of lipid bilayer properties. Biophysical journal. 2013 Academic Article GET IT
Times cited: 39
Elongation factor Ts directly facilitates the formation and disassembly of the Escherichia coli elongation factor Tu·GTP·aminoacyl-tRNA ternary complex. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 28
Connecting the kinetics and energy landscape of tRNA translocation on the ribosome. PLoS computational biology. 2013 Academic Article GET IT
Times cited: 68
Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 97
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 124
Allosteric control of the ribosome by small-molecule antibiotics. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 102
On the Mechanisms of Cyanine Fluorophore Photostabilization. The journal of physical chemistry letters. 2012 Academic Article GET IT
Times cited: 72
Enhanced photostability of cyanine fluorophores across the visible spectrum. Nature methods. 2012 Letter GET IT
Times cited: 98
Mechanistic insights into antibiotic action on the ribosome through single-molecule fluorescence imaging. Annals of the New York Academy of Sciences. 2011 Review GET IT
Times cited: 2
Cyanine fluorophore derivatives with enhanced photostability. Nature methods. 2011 Academic Article GET IT
Times cited: 214
Insights into the molecular determinants of EF-G catalyzed translocation. RNA (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 27
Structure and dynamics of the mammalian ribosomal pretranslocation complex. Molecular cell. 2011 Academic Article GET IT
Times cited: 77
Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 284
Conformational capture of the SAM-II riboswitch. Nature chemical biology. 2011 Academic Article GET IT
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature. 2011 Academic Article GET IT
Times cited: 192
Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 31
Correlated conformational events in EF-G and the ribosome regulate translocation. Nature structural & molecular biology. 2010 Academic Article GET IT
Times cited: 77
Probing translation with small-molecule inhibitors. Chemistry & biology. 2010 Review GET IT
Times cited: 36
Single-molecule dynamics of gating in a neurotransmitter transporter homologue. Nature. 2010 Academic Article GET IT
Times cited: 208
Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome. Journal of molecular biology. 2010 Academic Article GET IT
Times cited: 101
Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways. RNA (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 150
Aminoglycoside activity observed on single pre-translocation ribosome complexes. Nature chemical biology. 2010 Academic Article GET IT
Times cited: 10
A fast dynamic mode of the EF-G-bound ribosome. The EMBO journal. 2009 Academic Article GET IT
Times cited: 62
Spontaneous formation of the unlocked state of the ribosome is a multistep process. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 100
Relating diffusion along the substrate tunnel and oxygen sensitivity in hydrogenase. Nature chemical biology. 2009 Academic Article GET IT
Times cited: 166
Aminoglycoside activity observed on single pre-translocation ribosome complexes. Nature chemical biology. 2009 Academic Article GET IT
Times cited: 77
Navigating the ribosome's metastable energy landscape. Trends in biochemical sciences. 2009 Review GET IT
Times cited: 100
Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging. Biophysical journal. 2009 Academic Article GET IT
Times cited: 154
When starting over makes more sense. ACS chemical biology. 2009 Academic Article GET IT
Single-molecule observations of ribosome function. Current opinion in structural biology. 2009 Review GET IT
Times cited: 70
A new view of protein synthesis: mapping the free energy landscape of the ribosome using single-molecule FRET. Biopolymers. 2008 Review GET IT
Times cited: 43
Breaking the barriers of translation. Nature chemical biology. 2008 Article GET IT
Times cited: 2
The role of fluctuations in tRNA selection by the ribosome. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 85
Identification of two distinct hybrid state intermediates on the ribosome. Molecular cell. 2007 Academic Article GET IT
Times cited: 215
Site-specific labeling of the ribosome for single-molecule spectroscopy. Nucleic acids research. 2005 Academic Article GET IT
Times cited: 94
tRNA selection and kinetic proofreading in translation. Nature structural & molecular biology. 2004 Academic Article GET IT
Times cited: 380
tRNA dynamics on the ribosome during translation. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 373
Solution structure of the A loop of 23S ribosomal RNA. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 45
Approaching translation at atomic resolution. Nature structural biology. 2000 Review GET IT
Times cited: 36
rRNA chemical groups required for aminoglycoside binding. Biochemistry. 1998 Academic Article GET IT
Times cited: 45
Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic. Science (New York, N.Y.). 1996 Academic Article GET IT
Times cited: 738
RNA sequence determinants for aminoglycoside binding to an A-site rRNA model oligonucleotide. Journal of molecular biology. 1996 Academic Article GET IT
Times cited: 236
Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex. Science (New York, N.Y.). 1995 Academic Article GET IT
Times cited: 319

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Research

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Funding awarded

Cyclization Cascades to Access Bioactive Diterpenoids awarded by National Institute of General Medical Sciences Principal Investigator Subaward 2018 - 2023

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Background

education and training

Ph.D., Stanford University 2002
B.S., University of California, Santa Cruz 1994
B.A., University of California, Davis 1991

Contact

full name

Scott C. Blanchard

primary email

scb2005@med.cornell.edu

VIVO Weill Cornell Medical College

Scott C. Blanchard Adjunct Professor of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email